Neutrophilic dermatoses - Part I;Dermatoses neutrofílicas - Parte I

Anais Brasileiros de Dermatologia

Volumn 86, Issue 1, 2011, Pages 11-27

  Bonamigo, Renan Rangel ^a   Razera, Fernanda ^b   Olm, Gislaine Silveira ^b  

^a Federal University of Porto Alegre (UFCSPA)   (Brazil)

^b Health Sciences   (Brazil)

Author keywords

Behcet's Syndrome; Pyoderma; Sweet Syndrome; Urticaria

Indexed keywords

ANTICOAGULANT AGENT; AZATHIOPRINE; CHLORAMBUCIL; CHLORMETHINE; CLOFAZIMINE; COLCHICINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DAPSONE; DOXYCYCLINE; ETANERCEPT; ETRETINATE; INDOMETACIN; INFLIXIMAB; INTERFERON; METHOTREXATE; METRONIDAZOLE; MINOCYCLINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; POTASSIUM IODIDE; PREDNISOLONE; PREDNISONE; SALAZOSULFAPYRIDINE; TACROLIMUS; TETRACYCLINE; THALIDOMIDE; TRIAMCINOLONE ACETONIDE; TRICLOSAN; UNINDEXED DRUG;

ACUTE FEBRILE NEUTROPHILIC DERMATOSIS; ARTHRALGIA; ARTHRITIS; BEHCET DISEASE; BULLOUS SKIN DISEASE; CLINICAL FEATURE; CORTICOSTEROID THERAPY; DISEASE CLASSIFICATION; HISTOPATHOLOGY; HUMAN; NEUTROPHILIC DERMATOSIS; NEUTROPHILIC URTICARIA; PATHOGENESIS; PLASMAPHERESIS; PYODERMA GANGRENOSUM; REVIEW; SKIN DISEASE; URTICARIA;

BEHCET SYNDROME; DERMATOLOGIC AGENTS; FEMALE; HUMANS; MALE; NEUTROPHIL INFILTRATION; PYODERMA GANGRENOSUM; SWEET SYNDROME; URTICARIA;

EID: 79953303674     PISSN: 03650596     EISSN: 18064841     Source Type: Journal    
DOI: 10.1590/S0365-05962011000100002     Document Type: Review

References (143)

1. Cohen PR, Kurzrock R. Sweet's syndrome revisited: a review of disease concepts. Int J Dermatol. 2003;42:761-78.
2. Cohen PR, Kurzrock R. Sweet's syndrome. A review of current treatment options. Am J Dermatol. 2002;3:117-31.
3. Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964;76:349-56.
4. Su WP, Liu HN. Diagnostic criteria for Sweet's syndrome. Cutis. 1986;37:167-74.
5. Von den Driesch P. Sweet's syndrome (acute febrileneutrophilic dermatosis). J Am Acad Dermatol. 1994;31:535-56.
6. Cohen PR. Sweet's syndrome - a comprehensive review of an acute febrile neutrophilic dermatosis. Orph J R Dis. 2007;2:2-34.
7. Giasuddin AS, El-Orfi AH, Ziu MM, El-Barnawi NY. Sweet's syndrome: Is the pathogenesis mediated by helper T cell type 1 cytokines? J Am Acad Dermatol. 1998;39:940-3.
8. Mizoguchi M, Matsuki K, Mochizuki M, Watanabe R, Ogawa W, Harada S, Hino H, Amagai M, Juji T. Human leukocyte antigen in Sweet's syndrome and its relationship to Behçet disease. Arch Dermatol. 1998;124:1069-73.
9. Von den Driesch P, Simon M, Djawari D, Wassmuth R. Analysis of HLA antigens in Caucasian patients with acute febrile neutrophilic dermatosis (Sweet's syndrome). J Am Acad Dermatol. 1997;37:276-8.
10. Parsapour K, Reep MD, Gohar K, Shah V, Church A, Shwayder TA. Familial Sweet's syndrome in 2 brothers, both seen in the first 2 weeks of life. J Am Acad Dermatol. 2003;49:132-8.
11. Saavedra AP, Kovacs SC, Moschella SL. Neutrophilic dermatoses. Clin Dermatol. 2006;24:470-81.
12. Larsen HK, Danielsen AG, Krustrup D, Weismann K. Neutrophilic dermatosis of dorsal hands. Eur J Acad Dermatol Venerol. 2005;19:634-37.
13. Walling HW, Snipes CJ, Gerami P, Piette WW. The relationship between neutrophilic dermatosis of the dorsal hands and sweet syndrome. Arch Dermatol. 2006;142:57-63.
14. Astudillo L, Sailler L, Launay F, Josse AG, Lamant L, Couret B, Arlet-Suau E. Pulmonary involvement in Sweet's syndrome: a case report and review of literature. Int J Dermatol. 2006:45:677-80.
15. Gille J, Spieth K, Kaufmann R. Sweet's syndrome as initial presentation of diffuse large B-cell lynphoma. J Am Acad Dermatol. 2002;46:11-13.
16. Buck T, Gonzáles LM, Lambert WC, Schwartz RA. Sweet's syndrome with hematologic disorders: a review and reppraisal. Int J Dermatol. 2008;47:775-82.
17. Nischal KC, Khopkar U. An aproach to the diagnosis of neutrophilic dermatoses: A histopathological perspective. Indian J Dermatol Venerol Leprol. 2007:13:222-30.
18. Requena L, Kutzner H, Palmedo G, Pascual M, Fernández-Herrera J, Fraga J, Gracia-Diez A, Sánchez Y. Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. Arch Dermatol. 2005;141:834-42.
19. Walker DC, Cohen PR. Trimethoprim-sulfamethoxazole associated acute febrile neutrophilic dernatosis: case report and review of drug-induced Sweet's syndrome. J Am Acad Dermatol. 1996;34:918-23.
20. Cabanillas M, Suárez-Amor O, Sánchez-Aguilar D, Pereiro MM, Toribio J. Chronic recurrent neutrophilic dermatosis: A possible variant in the Spectrum of neutrophilic dermatoses. Actas Dermosifiliogr. 2008;99:61-3.
21. Farhi D, Wallach D, Avril MF. Pyoderma gangrosum is 100 years old: from Luois Brocq to the biologics era. Rev Prat. 2008;58;457-461.
22. Brunsting LA, Goeckerman WH, O'Leary PA. Pyoderma (ecthyma) gangrenosum. Clinical and experimental observations in five cases occuring in adults. Arch Derm Syphilol. 1930;22:655-680.
23. Hasselmann DO, Bens G, Tilgen W, Reichrath J. Pyoderma gangrenosum;clinical presentation and outcome in 18 cases and review of the literature. J Dtsch Dermatol Ges. 2007;5:560-564.
24. Brooklyn TN, Willians AM, Dunnill MG, Probert CS. T-cell receptor repertoire in pyoderma gangrenosum; evidence for clonal expansions and traffickin. Br J Dermatol. 2007;157:960-6.
25. Bister V, Mäkitalo L, jeskanen L, Saarialho-Kere U. Expression of MMP-9, MMP-10, and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum. J Cutan Pathol. 2007;34:889-98.
26. Pessato S, Bonamigo RR, Leite CM, Brodt C, Sperhacke C, Bakos L. Rev Amrigs. 1996;40:49-51.
27. Souza CS, Chiossi MPV, Takada MH, Foss NT, Roselino AMF. Pioderma gangrenoso: casuística e revisão de aspectos clínico-laboratoriais e terapêuticos. An Bras Dermatol. 1999;74:465-472.
28. Farasat S, Aksentijevich I, Toro JR. Autoinflammatory diseases: clinical and geneitic advances. Arch Dermatol. 2008;144:392-402.
29. Kanazawa N, Furukawa F. Autoinflammatory syndromes with a dermatological perspective. J Dermatol. 2007;34:601-18.
30. McAleer MA, Powell FC, Devaney D, O'Donnell BF. Infantile pyoderma gangrenosum. J Am Acad Dermatol. 2008;58:S23-8.
31. Sandhu K, Handa S, Kanwar AJ. Idiopathic pyoderma gangrenosum in a child. Ped Dermatol. 2004;21:276-277.
32. Barbato MT, Bakos L, Masiero NCMS, Bolson P. Perfil clinicopatológico dos pacientes com pioderma gangrenoso do Hospital de Clínicas de porto Alegre (RS). An Bras Dermatol. 2008;83:431-436.
33. Marzano AV, Tourlaki A, Alessi E, Caputo R. Widespread idiopathic pyoderma gangrenosum evolvedvfrom ulcerative to vegetative type: a 10-year hoistory with a recent response to infliximab. C Exp Dermatol. 2008;33:156-9.
34. Keltz M, Lebwohl M, Bishop S. Peristomal pyoderma gangrenosum. J Am Acad Dermatol. 1992;27:360-4.
35. Lyon CC, Smith AJ, Beck MH, Wong GA, Griffiths CE. Parastomal pyoderma gangrenosum: clinical features and management. J Am Acad Dermatol. 2000;42:992-1002.
36. Sheldon DG, Sawchuk LL, Kozarek RA, Thirlby RC. Twenty cases of perostomal pyoderma gangrenosum; diagnsotic implications and management. Arch Surg. 2000;135:564-568.
37. Hughes AP, Jackson JM, Callen JP. Clinical features and treament of paristomal pyoderma gangrenosum. JAMA. 2000;284:1546-1548.
38. Ballo FS, amisa C, Allen CM. Pyostomatitis vegetans. Report of a case and review of the literature. J Am Acad Dermatol. 1989;21:381-387.
39. Bennett ML, Jackson JM, Jorizzo JL, Fleischer AB Jr, White WL, Callen JP. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (baltimore) 2000;79:37-46.
40. Hickman JG. Pyoderma gangrenosum. Clin Dermatol. 1983;1102-113.
41. Callen JP. Pgrenosum and related disorders. Med North Am. 1989;73:1247.
42. Chahine B, Chenivesse C, Tillie-Leblond I, Delaponte E, Scherpereel A, Grignet JP, Tonnel AB. Pulmonary manifestations of Pyoderma gangrenosum. Presse Med. 2007;36:1395-8.
43. Mirkamali A, Martha B, Dutronc Y, Ponnelle T, Pana L, favrolt N, Chavanet P, Bernard A, Piroth L. Abcès pulmonaire et Pyoderma gangrenosum. Med Mal Infect. 2007;37:835-839.
44. Fournié P, malecaze F, Coullet J, Arné JL. Pyoderma gangrenosum with necrotizing sclerokeratitis aftaer cataract surgery. J Cataract Refract Surg. 2007;33:1987-90.
45. Powell FC, Schroeter AL, Su WP, Perry HO. Pyoderma gangrenosum: a review of 86 patients. Q J Med. 1985;55173-186.
46. Cave DR, Burakoff R. Pyoderma gangrenosum associated with ulcerative colitis: treatment with disodium cromoglycate. Am J Gastroenterol. 1987;82:802-804.
47. Galun E, Flugelman MY, Rachmilewitz D. Pyoderma gangrenosum. A complicating ulcerative colitis: successful with methylprednisole pulse therapy and dapsone. Am J Gastroenterol. 1986;81:988-989.
48. Roé E, Dalmau J, Garcia Navarro X, Corella F, Monfort D, Busquets D, Ribé A, Delgado E, Alomar A. A case of vulvar pyoderma gangrenosum associated with collagenous colitis. Dermatology. 2006;213:234-5.
49. Vadillo M, Jucgla A, Podzamczer D, Rufi G, Domingo A. Pyoderma gangrenosum with liver, spleen and boné involvement in a patient with chrnic myelomonocytic. Br J Dermatol. 1999;141:541-43.
50. Saito S, Yasui K, hosoda W, Ogawa M, Kobayashi N, Sakashita K, Koike K. CD30+anaplastic large cell limphoma complicated by pyoderma gangrenosum with increased levels of serum. Eur J Haematol. 2006;77:251-4.
51. Magro Cm, Kiani B, Li J, Crownson NA. Clonality in the setting of Sweet's syndrome and pyoderma gangrenosum is not limited to underlying myeloproliferative disease. J Cutan Pathol. 2007;34:526-34.
52. Puechguiral-Renaud I, Carpentier O, Piette F, Delaporte E. Subcorneal pustulosis and pyoderma gangrenosum associated with biclonal gammopathy. Eur J Dermatol. 2006;16:687-90.
53. Fearfield LA, Ross JR, Farrell AM, Costello C, Bunker CB, Staughton RC. Pyoderma gangrenosum associated with Takayasu's arteritis responding to cyclosporin. Br J Dermatol. 1999;141:339-43.
54. Yurci A, guven K, Torun E, Gursoy S, baskol M, Akgun H, Ozbakir O, Yucesoy M. pyoderma gangrenosum and exacerbation of psoriasis resulting from pegylated interferon alpha and ribavirin tratment of chronic hepatitis C. Eur J gastroenterol Hepatol. 2007:19:811-5.
55. Sandhu K, Handa S, Kanwar AJ. Anticoagulant-responsive pyoderma gangrenosum associated with an underlying prothrombotic dysfibrinogenemia. Br J Dermatol. 2005;153:1067-92.
56. Livideanu C, Lipsker D, Paul C, Juillard J, Schubert b. Pyoderma gangrenosum as initial manifestation of Grave's disease. Clin Exp Dermatol. 2006;31:659-61.
57. Ouazzani A, Berthe JV, de Fontaine S. post-surgical pyoderma gangrenosum: a clinical entity. Acta Chir Belg. 2007;107:424-8.
58. Bonamigo RR, Behar P, Beller C, Bonfá R. Pyoderma gangrenosum after silicone prosthesis implant in the breasts and facial plastic surgery. Int J Dermatol. 2008;47:289-91.
59. Weenig RH, Davis MD, dahl PR, Su WP. Skin ulcers misdiagnosed as pyoderma gangrenosum. N Engl J Med. 2002;347:1412-8.
60. Powell FC, Hackett BC. Pyoderma gangrenosum. In: Fitzpatrick's Dermatology in General Medicine. Wolff K, Goldsmith LA, Katz S, Gilchrest BA, Paller AS, Leffel DJ, eds. 7thed. McGraw-Hill: New York, USA; 2008. p. 296-302.
61. Peachey RD. Pyoderma gangrenosum of the scalp. Br J Dermatol. 1974;90:106-8.
62. Gardner LW, Acker DW. Triancinolone and pyoderma gangrenosum. Arch Dermatol. 1972;106:599-600.
63. de Cock KM, Thorne MG. The treatment of pyoderma gangrenosum with sodium cromoglycate. Br J Dermatol. 1980;102:231-233.
64. Ghislain PD, De Decker I, Lachapelle JM. Efficacy and systemic absorption of topical tacrolimus used in pyoderma gangrenosum. Br J Dermatol. 2004;150:1052-3.
65. Reich K, Vente C, Neumann C. Topical tacrolimus for pyoderma gangrenosum. Br J Dermatol. 1998;139:755-7.
66. Lyon CC, Stapleton M, Smith AJ, Mendelsohn S, Beck MH, Griffiths CE. Topical tacrolimus in the management of peristomal pyoderma gangrenosum. J Dermatol Treat. 2001;12;13-17.
67. Mrowietz U, Christophers E. Clearing of pyoderma gangrenosum by intralesional cyclosporin A. Br J Dermatol. 1991;125;498-9.
68. Berth-Jones. Pyoderma gangrenosum. In: Treatament of Skin Disease - comprehensive therapeutic strategies. Lebwohl MG, Heymann WR, Berth-Jopnes J, Coulson I, eds. 2nd ed. Lippincott Williams & Wilkins: Philadelphia, USA; 2006. p. 560-64.
69. Holt PJ, Davies MG, Saundres KC, Nuki G. Pyoderma gangrenosum. Clinical and laboratory findings in 15 patients with special reference to polyarthritis. Medicine. 1980;59:114-133.
70. Johnson RB, Lazarus GS. Pulse therapy. Therapeutic fficacy in the treatment of pyoderma gangrenosum. Arch Dermatol. 1982;118:76-84.
71. Elgart G, Stover P, Larson K, Sutter C, Scheibner S, Davis B, Bass J. Treatment of pyoderma gangrenosum with cyclosporine: results in seven patients. J Am Acad Dermatol. 1991;24;83-86.
72. Teitel AD. Treatment of pyoderma gangrenosum with methotrexate. Cutis. 1996;57:326-328.
73. Michaëlsson G, Molin L, Ohman S, Gip L, Lindström B, Skogh M, Trolin I. Clofazimine. A new agent fos treatment of pyoderma gangrenosum. Arch Dermatol. 1976;112:344-349.
74. Thomsen K, Rothenborg HW. Clofazimine in the treatment of pyoderma gangrenosum. Arch Dermatol. 1979;115:851-852.
75. Lorincz AL, Pearson RW. Sulfapyridine and sulphone type drugs in dermatology. Arch Dermatol. 1962;85:2-16.
76. Rampal P, Benzaken S, Scneider S, Hebuterne X. Colchicine in pyoderma gangrenosum. Lancet. 1998;351:1134-1135.
77. Munro CS, Cox NH. Pyoderma gangrenosum associated with Behçet syndrome - response thalidomide. Clin Exp Dermatol. 1988;13:408-410.
78. Buruss JB, Farmer ER, Callen JP. Chlorambucil is an effective corticosteroid sparing agent for recalcitrant pyoderma gangrenosum. J Am Acad Dermatol. 1996;35:720-724.
79. Lee MR, Cooper AJ. Mycophenolate mofetil in pyoderma gangrenosum. J Dermatol Treat. 2004;15:303-307.
80. Berth-Jones J, Tan SV, Graham-Brown RAC, Pembroke AC. The successful use of minocycline in pyoderma gangrenosum - areport of seven cases and review of the literature. J Dermatol Treat. 1989;1:23-25.
81. Zonana-Nacach A, Jimenez-Balderas FJ, Martinez-Osuna P, Mintz G. Intravenous cyclophosphamide pulses in the treatment of pyoderma gangrenosum associated with rheumatoid arthritis: report of 2 cases and review of the literature. J Rheumatol. 1994;21:1352-1356.
82. Okuma K, Mitsuuishi K, Hasegawa T, Tsuchihashi H, Ogawa H, Ikeda S. A case report of steroid and immunosuppressant-resistant pyoderma gangrenosum successfully by granulocytapheresis. Ther Apher Dial. 2007;11:387-90.
83. Tsele E, Yu RC, Chu AC. Pyoderma gangrenosum - response to topical nitrogen mustard. Clin Exp Dermatol. 1992;17:437-40.
84. Cliff S, Holden CA, Thomas PR, Marsden RA, Harland CC. Split skin grafts in the treatment of pyoderma gangrenosum: a report of four cases. Dermatol Surg. 1999;25:299-302.
85. Wolinna U, Karamfilov T. Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix. J Eur Acad Dermatol Venereol. 2000;14:187-190.
86. Braun-Falco M, Stock K, Ring J, Hein R. Topical platelet-derived growth factor accelerates healing healing of myelodiysplastic syndrome-associated pyoderma gangrenosum. Br J Dermatol. 2002;147:829-831.
87. Shpiro D, Gilat D, Fisher-Feld, Shemer A, Gold I, Trau H. Pyoderma gangrenosum successfully treated with perilesional granulocyte-macrophage colony stimulating factor. Br J Dermatol. 1998;138:368-369.
88. Tutrone WD, Green K, Weinberg JM, Caglar S, Clarke D. Pyoderma gangrenosum: dermatologic application of hiperbaric oxygen therapy. J Drugs Dermatol. 2007;6:1214-9.
89. Sapienza MS, Cohen S, Dimarino AJ. Treatment of pyoderma gangrenosum with infliximab in Crohn disease. Dig Dis Sci. 2004;49:1454-1457.
90. Charles CA, Leon A, Banta MR, Kirsner RS. Etarnercept for the treatment of refractory pyoderma gangrenosum: a brief series. Int J Dermatol. 2007;46:1095-9.
91. Heffernan MP, Anadkat MD, Smith DI. Adalimumab treatment for pyoderma gangrenosum. Arch Dermatol. 2007;143:306-308.
92. Farasat S, Aksentijevich I, Toro JR. Autoinflammatory Diseases: Clinical and Genetic Advances. Arch Dermatol. 2008;144:392-402.
93. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet's disease. N Engl J Med. 1999;341:1284-91.
94. Feigenbaum A. Description of Behcet's syndrome in the Hippocratic third book of endemic diseases. Br J Ophthalmol. 1956;40:355-7.
95. Mutlu S, Scully C. The person behind the eponym: Hulusi Behcet (1889-1948). J Oral Pathol Med. 1994;23:289-90.
96. Yurdakul S, Hamuryudan V, Yazici, H. Behet syndrome. Curr Opin Rheumatol. 2004;16:38.
97. Tüzün Y, Yurdakul S, Cem Mat M, Ozyazgan Y, Hamuryudan V, Tüzün B, et al. Epidemiology of Behçet's syndrome in Turkey. Int J Dermatol. 1996;35:618-620.
98. Alpsoy E, Uzun S, Akman A, Acar MA, Memisoglu HR, Basarant E. Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behçet's disease. J Eur Acad Dermatol Venereol. 2003;17:521-524.
99. Önder M, Gürer MA. The multiples faces of Behçet's disease and its aetiological factors. J Eur Acad Dermatol. 2001;15:126-136.
100. Yazici H, Tüzün Y, Pazarli H, Yurdakul S, Ozyazgan Y, Ozdoan H, et al. Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behcet's syndrome. Ann Rheum Dis. 1984;43:783-9.
101. Park KD, Bang D, Lee ES, Lee SH, Lee S. Clinical study on death in Behcet's disease. J Korean Med Sci. 1993;8:241-5.
102. O'Duffy JD. Behcet's disease. Curr Opin Rheumatol. 1994;6:39-43.
103. Akmaz Ö, Erel A, Gürer MA. Comparison of histopathologic and clinical evaluations of pathergy test in Behçet's disease. Int J Dermatol. 2000;39:121-125.
104. Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet. 1990;335:1078-80.
105. Zouboulis CC et al. Evaluation and revision of the International Criteria for Behçet Disease. Abstract of the 21st World Congress of Dermatology, Buenos Aires, Argetina, 2007.
106. Suzuki Kurokawa M, Suzuki N. Behçet's disease. Clin Exp Med. 2004;4:10.
107. Zouboulius CC. Adamantiades-Behçet Disease. In: Fitzpatrick's Dermatology in General Medicine. Wolff K, Goldsmith LA, Katz S, Gilchrest BA, Paller AS, Leffel DJ, eds. 7thed, 2008, 1620-1626. McGraw-Hill: New York, USA.
108. Alpsoy, E. Behcet's disease: Treatment of mucocutaneous lesions. Clin Exp Rheumatol. 2005;23:532-9.
109. Ravitskiy L, Green JJ, Goldenberg G, Jorizzo JL. Behçet's disease. In: Treatament of Skin Disease - comprehensive therapeutic strategies, Lebwohl MG, Heymann WR, Berth-Jopnes J, Coulson I, eds. 2nd ed. Philadelphia: USA; 2002. p. 82-85.
110. Yurdakul S, Mat C, Tuzun Y, Ozyazgan Y, Hamuryudan V, Uysal O, Senocak M, Yazici H. A double-blind trial of colchicine in Behçet's syndrome. Arthritis Rheum. 2001;44:2686-2682.
111. Sharquie KE, Najim RS, Abu-Raghif AR. Dapsone in Behçet disease: a doubleblind, placebo-controlled, cross-over study. J Dermatol. 2002;29:2667-79.
112. Hamuryudan V, Mat C, Saip S, Ozyazgan Y, Siva A, Yurdakul S, et al. Thalidomide in the treatment of the mucocutaneous lesions of Behçet's syndrome: a randomized double. Ann Intern Med. 1998;128:443-50.
113. Jorizzo JL, White WL, Wise CM, Zanolli MD, Sherertz EF. Low-dose weekliy methotrexate for unusual neutrophilic vascular reactions: cutaneous polyarteritis nodosa and Behçet's disease. J Am Acad Dermatol. 1991;24:973-8.
114. Yazici H, Barnes CG. Pratical treatment recommendations for pharmacotherapy of Behçet's syndrome. Drugs. 1991;42:796-804.
115. Kötter I, Vonthein R, Zierhut M, Eckstein AK, Ness T, Günaydin I, et al. Differrencial efficacy of human recombinant interferon alpha2a on ocular and extraocular manifestations of Behçet disease: results of an open 4-center trial. Sem Arthritis Rheum. 2004;33:311-9.
116. Calguneri M, Ertenli I, Kiraz S, Erman M, Celik I. Effect of of prophylactic benzathine penicillin on mucocutaneous symptoms of Behçet's disease. Dermatology. 1996;192:125-8.
117. Simsek H, Dundar S, Telatar H. Treatment of Behçet disease with indomethacin. Int J Dermatol. 1991;30-54-7.
118. Orfanos CE, Bauer R Evidence for anti-inflammatory activities of oral synthetic retinoids: experimental findings and clinical experience. Br J Dermatol. 1983;109:55-60.
119. Masuda K, Nakajima A, Urayama A, Nakae K, Kogure M, Inaba G. Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behçet disease. Lancet. 1989;1:1093-6.
120. Avci O, Gurler N, Gunes AT. Efficacy of cyclosporine on mucocutaneous manifestations of Behçet's disease. J Am Acad Dermatol. 1997;36:796-7.
121. Yazici H, Pazarli H, Barnes CG, Tüzün Y, Ozyazgan Y, Silman A, et al. A controlled trial of azathioprine in Behçet's syndrome. N Eng J Med. 1990;322:281-5.
122. Buckley CE III, Giilis JP Jr. Cyclophosphamide therapy of Behçet's disease. J Allergy 1969;64:105-12.
123. O'Duffy JD, Robertson DM, Goldstein NP. Chlorambucil in the treatment of uveitis and menin-goencephalitis of Behçet's disease. Am J Med. 1984;76:75-84.
124. Kaneko F, Oyama N, Nishibu A. Streptococcal infection in the pathogenesis of Behçet's disease and clinical effects of minocycline on the disease symptoms. Yonsei Med J. 1997;38:444-54.
125. Cornelis F, Sigal-Nahum M, Gaulier A, Bleichner G, Sigal S. Behçet's disease with severe cutaneous necrotizing vasculitis: response to plasma exchange - report of a case. J Am Acad Dermatol. 1989;21:576-9.
126. Takeuchi A, Hashimoto T. Oral protaglandin E1 as a therapeutic modality for legulcers in Behçet's disease. Int J Clin Pharm Res. 1987;7:283-9.
127. Seider N, Beiran I, Scharf J, Miller B. Intravenous immunoglobulin therapy for resistant ocular Behçet disease. Br J Ophthalmol. 2001;85:1287-8.
128. Matsuda T, Ohno S, Hirohata S, Miyanaga Y, Ujihara H, Inaba G, et al. Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet disease. Drugs R D. 2003;4:19-28.
129. Sfikakis PP. Behçet disease: a new target for anti-tumor necrosis factor treatment. Ann Rheum Dis. 2002;61(suppl):ii51-ii53.
130. Ohno S, Nakamura S, Hori S, Shimakawa M, Kawashima H, Mochizuki M, et al. Efficacy, safety, and pharmacokinetics of multiple administrations of infliximab in Behçet's disease with refractory uveoretinitis. J Rheum. 2004;31-1362-8.
131. Melikoglu M, Fresko I, Mat C, et al. A double blind placebo controlled trial of etanercept on the mucocutaneous lesions of Behçet's disease. Book of Abstracts. Berlin: 10th International Congress on Behçet's disease;2002:Abs.48.
132. Stanford M, Whittall T, Bergmeier LA, Lindblad M, Lundin S, Shinnick T, et al. Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behçet's disease. Clin Exp Immunol. 2004;137:201-8.
133. De Merieux P, Spitler LE, Paulus HE. Treatment of Behcet's syndrome with levamisole. Arthritis Rheum. 1981;24:64-70.
134. Lockwood CM, Hale G, Waldman H, Jayne DR. Remission induction in Behçet's disease following lymphocyte depletion by the anti-CD52 antibody CAMPATH 1-H. Rheumatology (Oxford). 2003;42:1539-44.
135. Kanekura T, Gushi A, Iwata M, Fukumaru S, Sakamoto R, Kawahara K, et al. Treatment of Behçet's disease with granulocyte and monocyte adsorption apheresis. J Am Dermatol. 2004;51:S83-7.
136. Zouboulis, CC, Vaiopoulos, G, Marcomichelakis, N, Palimeris G, Markidou I, Thouas B, Kaklamanis P. Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades-Behcet's disease in Greece. Clin Exp Rheumatol. 2003;21:S19-26.
137. Peters MS, Winkelmann RK. Neutrophilic urticaria. British Journal of Dermatology. 1985,113:25-30.
138. Kieffer C, Crieber B, Lipsker D. Neutrophilic urticarial dermatosis: a variante of neutrophilic urticaria strongly associated with systemic disease. Report of new cases and review of literature. Medicine (Baltimore). 2009,88:23-31.
139. Winkelmann RK, Wilson-Jones E, Smith NP, English JS, Greaves MW. Neutrophilic urticaria. Acta Derm Venereol. 1988;68:129-33.
140. Toppe E, Haas N, Henz MB. Neutrophilic urticaria: clinical features, histological changes and possible mechanisms. Brit J Dermatol. 1998,138:248-253.
141. Winkelmann RK, Reizner GT. Diffuse dermal neutrophilia in urticaria. Hum Pathol. 1988;19:389-93.
142. Criado RF, Criado PR, Martins JED, Valente NYS, Michalany NS, Vasconcellos C. Urticaria unresponsive to antihistaminic treatment: An open study of therapeutic options base don histopathologic features. J Dermatol Treat. 2008;19:92-96.
143. Pires JS, Ue APF, Furlani WJ, Souza PK, Rotta O. Dapsona como alternativa no tratamento de urticária crônica não responsiva a anti-histamínicos. An Bras Dermatol. 2008;83:413-8.