Chlorambucil is an effective corticosteroid-sparing agent for recalcitrant pyoderma gangrenosum

Journal of the American Academy of Dermatology

Volumn 35, Issue 5 I, 1996, Pages 720-724

  Burruss, Jyoti B ^a   Farmer, Evan R ^b   Callen, Jeffrey P ^a,c  

^a University of Louisville School of Medicine   (United States)

^b INDIANA UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CHLORAMBUCIL; CLOFAZIMINE; COLCHICINE; CYCLOSPORIN; DAPSONE; IMMUNOSUPPRESSIVE AGENT; METHOTREXATE; METHYLPREDNISOLONE; MINOCYCLINE; PREDNISONE; SALAZOSULFAPYRIDINE; STEROID;

ADULT; ARTICLE; BONE MARROW TOXICITY; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG FEVER; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; LEUKEMIA; LUNG FIBROSIS; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PYODERMA GANGRENOSUM; SEIZURE; STEROID THERAPY;

EID: 0029968982     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0190-9622(96)90727-6     Document Type: Article

References (20)

1. Callen JP. Pyoderma gangrenosum and related disorders. Adv Dermatol 1989;4:51-70.
2. Hickman JG, Lazarus GS. Pyoderma gangrenosum: new concepts in etiology and treatment. In: Moschella SL, ed-itor. Dermatology update: review for physicians. Amsterdam: Elsevier Science Publishers, 1979:325-42.
3. Johnson RB, Lazarus GS. Pulse therapy: therapeutic efficacy in the treatment of pyoderma gangrenosum. Arch Dermatol 1982;118:76-84.
4. Matis WL, Ellis CN, Griffiths CEM, et al. Treatment of PG with cyclosporine. Arch Dermatol 1992;128:1060-4.
5. Perry HO, Brunsting LA. Pyoderma gangrenosum: a clinical study of nineteen cases. Arch Dermatol 1957;75:380-6.
6. Soto LD. Diaminodiphenyl sulfone and steroids in the treatment of pyoderma gangrenosum. Int J Dermatol 1970;4:293-300.
7. Brown RE, Lay L, Graham D. Bilateral pyoderma gangrenosum of the hand: treatment with dapsone. J Hand Surg [Br] 1993;18B:119-21.
8. Michaëlsson G, Molin L, Öhman S, et al. Clofazimine: a new agent for the treatment of pyoderma gangrenosum. Arch Dermatol 1976;112:344-9.
9. Teitel AD. Treatment of pyoderma gangrenosum with methotrexate [abstract]. Arthritis Rheum 1993;36:S163.
10. August PG, Wells GL. Pyoderma gangrenosum treated with azathioprine and prednisolone. Br J Dermatol 1974; 91(suppl):80-2.
11. Newell LM, Malkinson FD. Pyoderma gangrenosum: response to cyclophosphamide therapy. Arch Dermatol 1983;119:495-7.
12. Zonana-Nacach A, Jiménez-Balderas FJ, Mártinez-Osana P, et al. Intravenous cyclophosphamide pulses in the treatment of pyoderma gangrenosum associated with RA: report of two cases and review of the literature. J Rheumatol 1994;21:1352-6.
13. Abu-Elmagad K, Van Thiel DH, Jegasothy BV, et al. Resolution of severe pyoderma gangrenosum in a patient with streaking leukocyte factor disease after treatment with tacrolimus (FR506). Ann Intern Med 1993;119:595-8.
14. Gupta AK, Shear NH, Sauder DN. Efficacy of human intravenous immune globulin in pyoderma gangrenosum. J Am Acad Dermatol 1995;32:140-2.
15. Callen JP, Case JD, Sager D. Chlorambucil - an effective corticosteroid-sparing therapy for pyoderma gangrenosum. J Am Acad Dermatol 1989;21:515-9.
16. Resnik BI, Rendon M, Kerdel FA. Successful treatment of aggressive pyoderma gangrenosum with pulse steroids and Chlorambucil. J Am Acad Dermatol 1992;27:635-6.
17. Callen JP. Immunosuppressive and cytotoxic drugs: uses in the dermatologic patient. Adv Dermatol 1990;5:3-20.
18. Steinberg AD. Chlorambucil in the treatment of patients with immune mediated rheumatic diseases. Arthritis Rheum 1993;36:325-8.
19. Palmer RG, Denman AM. Malignancies induced by Chlorambucil. Cancer Treat Rev 1984;11:121-9.
20. French Cooperative Group on Chronic Lymphocytic Leukemia. Effects of Chlorambucil and therapeutic decision in initial forms of chronic lymphocytic leukemia (Stage A): results of a randomized clinical trial on 612 patients. Blood 1990;75:1414-21.