Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis

Molecular Carcinogenesis

Volumn 50, Issue 4, 2011, Pages 291-300

  Wang, Li Shu ^a   Dombkowski, Alan A ^b   Seguin, Claire ^a   Rocha, Claudia ^a   Cukovic, Daniela ^b   Mukundan, Anju ^b   Henry, Cassandra ^a   Stoner, Gary D ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Black raspberries; Chemoprevention; Microarray; Rat esophagus

Indexed keywords

LIPOXYGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; N BENZYL N METHYLNITROSAMINE; PROSTAGLANDIN SYNTHASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BLACK RASPBERRY; CARBOHYDRATE METABOLISM; CARCINOGENESIS; CELL ADHESION; CELL FUNCTION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DEATH; DNA MICROARRAY; ESOPHAGUS CARCINOMA; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOPATHOLOGY; INFLAMMATION; LIPID METABOLISM; MALE; METASTASIS; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RASPBERRY; RAT;

ANIMALS; ANTIGENS, CD34; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; DIMETHYLNITROSAMINE; DINOPROSTONE; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FRUIT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LEUKOTRIENE B4; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYTOTHERAPY; PLANT PREPARATIONS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROSACEAE; TIME FACTORS;

RATTUS; RUBUS OCCIDENTALIS;

EID: 79953300927     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20634     Document Type: Article

References (23)

1. Souza R. Molecular and biologic basis of upper gastrointestinal malignancy-Esophageal carcinoma. Surg Oncol Clin N Am 2002; 11: 257-272.
2. Stoner GD, Gupta A. Etiology and chemoprevention of esophageal squamous cell carcinoma. Carcinogenesis 2001; 22: 1737-1746.
3. Siglin JC, Brach DH, Stoner GD. Effects of dietary phenethyl isothiocyanate, ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. Carcinogenesis 1995; 16: 1101-1106.
4. Mandal S, Stoner GD. Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid. Carcinogenesis 1990; 11: 55-61.
5. Kresty LA, Morse MA, Morgan C, et al. Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 2001; 61: 6112-6119.
6. Wang LS, Hecht SS, Carmella SG, et al. Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev Res 2009; 2: 84-93.
7. Stoner GD, Dombkowski AA, Reen RK, et al. Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. Cancer Res 2008; 68: 6460-6467.
8. Lechner J, Reen R, Dombkowski A, et al. Effects of a black raspberry diet on gene expression in the rat esophagus. Nutr Cancer 2008; 60: 61-69.
9. Quackenbush J. Computational analysis of microarray data. Nat Rev Genet 2001; 2: 418-427.
10. Weng L, Dai H, Zhan Y, He Y, Stepaniants SB, Bassett DE. Rosetta error model for gene expression analysis. Bioinformatics 2006; 22: 1111-1121.
11. Gene Ontology Consortium. The gene ontology (GO) database and informatics resource. Nucl Acids Res 2004; 32: D258-D261.
12. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, editors. Bioinformatics methods and protocols. Methods in Molecular Biology Humana Press; Totowa, NJ: 2000. pp. 365-386.
13. Reen RK, Dombkowski AA, Kresty LA, et al. Effects of phenylethyl isothiocyanate on early molecular events in N-Nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus. Cancer Res 2007; 67: 6484-6492.
14. Liu C-G, Zhang L, Jiang Y, et al. Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. Cancer Res 2005; 65: 7790-7799.
15. Mitsui Y, Mochizuki S, Kodama T, et al. ADAM28 is overexpressed in human breast carcinomas: Implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. Cancer Res 2006; 66: 9913-9920.
16. Bera S, Wallimann T, Ray S, Ray M. Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells. FEBS J 2008; 275: 5899-5909.
17. Blish KR, Wang W, Willingham MC, et al. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. Mol Biol Cell 2008; 19: 457-464.
18. Wong YF, Cheung TH, Lo KWK, et al. Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling. Oncogene 2006; 26: 1971-1982.
19. Baram D, Mekori Y, Sagi-Eisenberg R. Synaptotagmin regulates mast cell functions. Immunol Rev 2001; 179: 25-34.
20. Sreenath A, Kumar K, Reddy G, et al. Evidence for the association of synaptotagmin with glutathione S-transferases: Implications for a novel function in human breast cancer. Clin Biochem 2005; 38: 436-443.
21. Amsellem-Ouazana D, Bièche I, Tozlu S, Botto H, Debré B, Lidereau R. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. J Urol 2006; 175: 1127-1132.
22. Rodrigo K, Rawal Y, Renner R, et al. Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Nutr Cancer 2006; 54: 58-68.
23. Zhi H, Zhang J, Hu G, et al. The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma. Int J Cancer 2003; 106: 327-333.