The association between platelet activation and FcγRIIa proteolysis

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 4, 2011, Pages 885-887

  Nazi, I ^a   Smith, J W ^a   Arnold, D M ^a   Horsewood, P ^a   Moore, J C ^a   Warkentin, T E ^a   Kelton, J G ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALOXISTATIN; FC RECEPTOR IIA; HIRUDIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IV.3; SEROTONIN; UNCLASSIFIED DRUG;

DRUG INHIBITION; ENZYME IMMUNOASSAY; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; LETTER; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEROTONIN RELEASE; THROMBOCYTE ACTIVATION; WESTERN BLOTTING;

BLOTTING, WESTERN; HUMANS; HYDROLYSIS; PLATELET ACTIVATION; RECEPTORS, IGG;

EID: 79953296214     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04239.x     Document Type: Letter

References (10)

1. Kelton JG, Sheridan D, Santos A, Smith J, Steeves K, Smith C, Brown C, Murphy WG. Heparin-induced thrombocytopenia: laboratory studies. Blood 1988; 72: 925-30.
2. Visentin GP, Ford SE, Scott JP, Aster RH. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 1994; 93: 81-8.
3. Warkentin TE, Sheppard JA, Moore JC, Moore KM, Sigouin CS, Kelton JG. Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: how much class do we need? J Lab Clin Med 2005; 146: 341-6.
4. Kelton JG, Smith JW, Santos AV, Murphy WG, Horsewood P. Platelet IgG Fc receptor. Am J Hematol 1987; 25: 299-310.
5. Mitchell MA, Huang MM, Chien P, Indik ZK, Pan XQ, Schreiber AD. Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis. Blood 1994; 84: 1753-9.
6. Smith JW, Horsewood P, Hayward CP, Warkentin TE, Kelton JG. Proteolysis of human FcRIIa during activation induced by heparin-induced thrombocytopenia (HIT) sera. [Abstract # 1963]. Blood 1999; 94(Suppl. 1): 442a.
7. Gardiner EE, Karunakaran D, Arthur JF, Mu FT, Powell MS, Baker RI, Hogarth PM, Kahn ML, Andrews RK, Berndt MC. Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. Blood 2008; 111: 165-74.
8. Gardiner EE, Al-Tamimi M, Mu FT, Karunakaran D, Thom JY, Moroi M, Andrews RK, Berndt MC, Baker RI. Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura. J Thromb Haemost 2008; 6: 1175-82.
9. Horsewood P, Hayward CP, Warkentin TE, Kelton JG. Investigation of the mechanisms of monoclonal antibody-induced platelet activation. Blood 1991; 78: 1019-26.
10. Zheng YM, Liu C, Chen H, Locke D, Ryan JC, Kahn ML. Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma -chain in response to the snake venom convulxin but not to collagen. J Biol Chem 2001; 276: 12999-3006.