The link between otitis media with effusion and allergy: A potential role for intranasal corticosteroids

Pediatric Allergy and Immunology

Volumn 22, Issue 3, 2011, Pages 258-266

  Lack, Gideon ^a   Caulfield, Helen ^b   Penagos, Martin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Allergic rhinitis; Ear; Otitis media with effusion

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; BECLOMETASONE DIPROPIONATE; DECONGESTIVE AGENT; DEXAMETHASONE; FLUTICASONE FUROATE; PLACEBO; PREDNISONE; STEROID; TRIAMCINOLONE ACETONIDE;

ALLERGIC RHINITIS; DISEASE ASSOCIATION; HUMAN; INFLAMMATION; NONHUMAN; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; SECRETORY OTITIS MEDIA;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADRENAL CORTEX HORMONES; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS AS TOPIC; HUMANS; HYPERSENSITIVITY; HYPERSENSITIVITY, IMMEDIATE; INFANT; OTITIS MEDIA WITH EFFUSION; RHINITIS, ALLERGIC, PERENNIAL; TREATMENT OUTCOME;

EID: 79953293734     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2010.01130.x     Document Type: Review

References (47)

1. Tos M. Epidemiology and natural history of secretory otitis. Am J Otol 1984: 5: 459-62.
2. Thomas CL, Simpson S, Butler CC, van der Voort JH. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev 2006: 3: CD001935.
3. American Academy of Family Physicians, American Academy of Otolaryngology-Head and Neck Surgery and American Academy of Pediatrics, Subcommittee on Otitis Media With Effusion. Otitis media with effusion: clinical practice guideline. Pediatrics 2004: 113: 1412-29.
4. Nguyen LHP, Manoukian JJ, Sobol SE, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol 2004: 114: 1110-5.
5. Sobol SE, Taha R, Schloss MD, et al. TH2 cytokine expression in atopic children with otitis media with effusion. J Allergy Clin Immunol 2002: 110: 125-30.
6. Hurst DS, Venge P. Evidence of eosinophil, neutrophil, and mast-cell mediators in the effusion of OME patients with and without atopy. Allergy 2000: 55: 432-41.
7. Hurst DS. Association of otitis media with effusion and allergy as demonstrated by intradermal skin testing and eosinophil cationic protein levels in both middle ear effusions and mucosal biopsies. Laryngoscope 1996: 106 (9 Pt 1): 1128-37.
8. Stool SE, Berg AO, Berman S, et al. Otitis Media with Effusion in Young Children. Clinical Practice Guideline, Number 12. AHCPR Publication No. 94-0622. Rockville: Agency for Health Care Policy and Research, Public Health Service, U.S. Department of Health and Human Services. July 1994.
9. Chalmers D, Stewart I, Silva P, Mulena A. Otitis Media with Effusion in Children - The Dunedin Study. Oxford: Mac Keith Press, 1989.
10. Williamson IG, Dunleavey J, Bain J, Robinson D. The natural history of otitis media with effusion - a three-year study of the incidence and prevalence of abnormal tympanograms in four South West Hampshire Infant and First schools. J Laryngol Otol 1994: 108: 930-4.
11. Rosenfeld RM, Kay D. Natural history of untreated otitis media. Laryngoscope 2003: 113: 1645-57.
12. Caffarelli C, Savini E, Giordano S, Cavagni G. Atopy in children with otitis media with effusion. Clin Exp Allergy 1998: 28: 591-6.
13. Shekelle P, Takata G, Chan LS, et al. Diagnosis, natural history, and late effects of otitis media with effusion. Evidence Report/Technology Assessment No. 55 (Prepared by Southern California Evidence-based Practice Center under Contract No. 290-97-0001, Task Order No. 4). AHRQ Publication No. 03-E023. Rockville: Agency for Healthcare Research and Quality May 2003.
14. Freemantle N, Sheldon TA, Song F, Long A. The Treatment of Persistent Glue Ear in Children: Are Surgical Interventions Effective in Combating Disability from Glue Ear? Leeds: University of Leeds 1992.
15. Midgley EJ, Dewey C, Pryce K, Maw AR, ALSPAC Study Team. The frequency of otitis media with effusion in British pre-school children: a guide for treatment. Clin Otolaryngol Allied Sci 2000: 25: 485-91.
16. Alles R, Parikh A, Hawk L, Darby Y, Romero JN, Scadding G. The prevalence of atopic disorders in children with chronic otitis media with effusion. Pediatr Allergy Immunol 2001: 12: 102-6.
17. Tomonaga K, Kurono Y, Mogi G. The role of nasal allergy in otitis media with effusion. A clinical study. Acta Otolaryngol Suppl 1988: 458: 41-7.
18. Tracy JM, Demain JG, Hoffman KM, Goetz DW. Intranasal beclomethasone as an adjunct to treatment of chronic middle ear effusion. Ann Allergy Asthma Immunol 1998: 80: 198-206.
19. Mandel EM, Casselbrant ML, Rockette HE, Fireman P, Kurs-Lasky M, Bluestone CD. Systemic steroid for chronic otitis media with effusion in children. Pediatrics 2002: 110: 1071-80.
20. Umapathy D, Alles R, Scadding GK. A community based questionnaire study on the association between symptoms suggestive of otitis media with effusion, rhinitis and asthma in primary school children. Int J Ped Otorhinolaryngol 2007: 71: 705-12.
21. Nsouli TM, Nsouli SM, Linde RE, O'Mara F, Scanlon RT, Bellanti JA. Role of food allergy in serous otitis media. Ann Allergy 1994: 73: 215-9.
22. Juntti H, Tikkanen S, Kokkonen J, Alho OP, Niinimäki A. Cow's milk allergy is associated with recurrent otitis media during childhood. Acta Otolaryngol 1999: 119: 867-73.
23. Luong A, Roland PS. The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngol Clin N Am 2008: 41: 311-23.
24. Doyle WJ, Friedman R, Fireman P, Bluestone CD. Eustachian tube obstruction after provocative nasal antigen challenge. Arch Otolaryngol 1984: 110: 508-11.
25. Downs BW, Butehorn HF, Prazma J, Rose AS, Stamat JC, Pillsbury HC. Action of histamine on Eustachian tube function. Otolaryngol Head Neck Surg 2001: 124: 414-20.
26. Ebert CS Jr, Rose AS, Blanks DA, et al. Immune modulatory oligonucleotides in prevention of nasal allergen-induced Eustachian tube dysfunction in rats. Otolaryngol Head Neck Surg 2007: 137: 250-5.
27. O'Connor RD, Ort H, Leong AB, Cook DA, Street D, Hamburger RN. Tympanometric changes following nasal antigen challenge in children with allergic rhinitis. Ann Allergy 1984: 53: 468-71.
28. Osur SL, Volovitz B, Dickson S, Enck DC, Bernstein JM. Eustachian tube dysfunction in children with ragweed hayfever during natural pollen exposure. Allergy Proc 1989: 10: 133-9.
29. Fireman P. Otitis media and nasal disease: a role for allergy. J Allergy Clin Immunol 1988: 82: 917-26.
30. Rovers MM, Straatman H, Ingels K, van der Wilt GJ, van den Broek P, Zielhuis GA. The effect of short-term ventilation tubes versus watchful waiting on hearing in young children with persistent otitis media with effusion: a randomized trial. Ear Hear 2001: 22: 191-9.
31. Lous J, Burton MJ, Felding JU, Ovesen T, Rovers MM, Williamson I. Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev 2005: 25: CD001801.
32. Johnston LC, Feldman HM, Paradise JL, et al. TM abnormalities and hearing levels at the ages of 5 and 6years in relation to persistent otitis media and tympanostomy tube insertion in the first 3years of life: a prospective study incorporating a randomized clinical trial. Pediatrics 2004: 114: e58-67.
33. Stenstrom R, Pless IB, Bernard P. Hearing thresholds and tympanic membrane sequelae in children managed medically or surgically for otitis media with effusion. Arch Pediatr Adolesc Med 2005: 159: 1151-6.
34. Paradise JL, Feldman HM, Campbell TF, et al. Tympanostomy tubes and developmental outcomes at 9 to 11years of age. N Engl J Med 2007: 356: 248-61.
35. Chimona T, Panayiotides JG, Papadakis CE, Helidonis ES, Velegrakis GA. Antihistamine effects on experimental middle ear inflammatory model. Eur Arch Otorhinolaryngol 2008: 265: 899-905.
36. Griffin GH, Flynn C, Bailey RE, Schultz JK. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2006: 18: CD003423.
37. Rosenfeld RM, Mandel EM, Bluestone CD. Systemic steroids for otitis media with effusion in children. Arch Otolaryngol Head Neck Surg 1991: 117: 984-9.
38. Butler CC, van Der Voort JH. Steroids for otitis media with effusion: a systematic review. Arch Pediatr Adolesc Med 2001: 155: 641-7.
39. Podoshin L, Fradis M, Ben-David Y, Faraggi D. The efficacy of oral steroids in the treatment of persistent otitis media with effusion. Arch Otolaryngol Head Neck Surg 1990: 116: 1404-6.
40. Schwartz RH. Otitis media with effusion: results of treatment with a short course of oral prednisone or intranasal beclomethasone aerosol. Otolaryngol Head Neck Surg 1981: 89: 386-91.
41. Lildholdt T, Kortholm B. Beclomethasone nasal spray in the treatment of middle-ear effusion - a double-blind study. Int J Pediatr Otorhinolaryngol 1982: 4: 133-7.
42. Scadding GK. Other anti-inflammatory uses of intranasal corticosteroids in upper respiratory inflammatory diseases. Allergy 2000: 55 (Suppl. 62): 19-23.
43. Shapiro GG, Bierman CW, Furukuwa CT, et al. Treatment of persistent eustacian tube dysfunction with aerosolised nasal dexamethasone phosphate versus placebo. Ann Allergy 1982: 49: 81-5.
44. Cengel S, Akyol MU. The role of topical nasal steroids in the treatment of children with otitis media with effusion and/or adenoid hypertrophy. Int J Pediatr Otorhinolaryngol 2006: 70: 639-45.
45. Akyol MU, Cengel S. The role of topical nasal steroid aerosol treatment in children with otitis media with effusion and/or adenoid hypertrophy. 12months follow-up. Presented at 2006 European Society of Paediatric Otorhinolaryngology Annual Meeting June 18, 2006: Paris, France.
46. Williamson I, Benge S, Barton S, et al. Topical intranasal corticosteroids in 4-11year old children with persistent bilateral otitis media with effusion in primary care: double blind randomised placebo controlled trial. BMJ 2009: 339: b4984.
47. Johansen EC, Lildholdt T, Damsbo N, Eriksen EW. Tympanometry for diagnosis and treatment of otitis media in general practice. Fam Pract 2000: 17: 317-22.