Antihistamines and/or decongestants for otitis media with effusion (OME) in children

Cochrane Database of Systematic Reviews

Volumn , Issue 4, 2006, Pages

  Griffin, Glenn H ^a   Flynn, C ^b   Bailey, R E ^b   Schultz, J K ^b  

^a Quinte West Medical Centre   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACRIVASTINE; ANTIHISTAMINIC AGENT; ASTEMIZOLE; AZATADINE; BROMPHENIRAMINE; CARBINOXAMINE; CETIRIZINE; CHLORPHENIRAMINE; CINNARIZINE; CLEMASTINE; DECONGESTIVE AGENT; DEXBROMPHENIRAMINE; DIPHENHYDRAMINE; DOXYLAMINE; EPHEDRINE; FEXOFENADINE; HYDROXYZINE; LORATADINE; MEPYRAMINE; NAPHAZOLINE; OXYMETAZOLINE; PHENIRAMINE; PHENYLEPHRINE; PHENYLPROPANOLAMINE; PLACEBO; PROPYLHEXEDRINE; PSEUDOEPHEDRINE; TERFENADINE; TRIPROLIDINE; XYLOMETAZOLINE;

CLINICAL TRIAL; COMPUTER PROGRAM; CONFIDENCE INTERVAL; FOLLOW UP; HUMAN; HYPERACTIVITY; OTITIS MEDIA; OUTCOME ASSESSMENT; QUALITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; SEDATION; SIDE EFFECT; STATISTICAL ANALYSIS; UNSPECIFIED SIDE EFFECT;

EID: 42749101565     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD003423.pub2     Document Type: Review

References (65)

1. Cantekin EI, Mandel EM, Bluestone CD, Rockette HE, Paradise JL, Stool SE, Fria TJ, Rogers KD. Lack of efficacy of a decongestant-antihistamine combination for otitismedia with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. New England Journal of Medicine 1983;308(6):297-301.
2. Cantekin EI, McGuire TW, Griffith TL. Antimicrobial therapy for otitis media with effusion ('secretory' otitis media).[see comment]. JAMA 1991;266(23):3309-17.
3. Dusdieker LB, Smith G, Booth BM, Woodhead JC, Milavetz G. The long-term outcome of nonsuppurative otitis media with effusion. Clinical Pediatrics 1985;24(4):181-6.
4. Dusdieker LB, Smith G, Booth BM, Woodhead JC, Milavetz G. The long-term outcome of nonsuppurative otitis media with effusion. Clinical Pediatrics 1985;24(4):181-6.
5. Edstrom S, Lundin K, Jeppsson PH. Secretory otitis media. Aspects on treatment and control. ORL: Journal of Oto-Rhino-Laryngology and its Related Specialties 1977;39(2):68-73.
6. Fabian P, Lonnerholm G, Jerrmark-Tera IB, Kleberg A, Melander H. [Effects and adverse effects of decongestants in otosalpingitis]. Lakartidningen 1986;83(42):3508-13.
7. Fraser JG, Mehta M, Fraser PA. The medical treatment of secretory otitis media. A clinical trial of three commonly used regimes. Journal of Laryngology and Otology 1977;91(9):757-65.
8. Haugeto OK, Schroder KE, Mair IW. Secretory otitis media, oral decongestant and antihistamine. Journal of Otolaryngology 1981;10(5):359-62.
9. Haugeto OK, Schroder KE, Mair IW. Secretory otitis media, oral decongestant and antihistamine. Journal of Otolaryngology 1981;10(5):359-62.
10. Hayden GF, Randall JE, Randall JC, Hendley JO. Topical phenylephrine for the treatment of middle ear effusion. Archives of Otolaryngology 1984;110(8):512-4.
11. Hughes KB. Management of middle-ear effusions in children. Journal of Laryngology and Otology 1984;98(7):677-84.
12. Khan JA, Marcus P, Cummings SW. S-carboxymethylcysteine in otitis media with effusion. (A double-blind study). Journal of Laryngology and Otology 1981;95(10):995-1001.
13. Lesser TH, Clayton MI, Skinner D. Efficacy of medical treatment as an adjunct to surgery in the treatment of secretory otitis media. Journal of Laryngology and Otology 1986;100(12):1347-50.
14. Mandel EM, Rockette HE, Bluestone CD, Paradise JL, Nozza RJ. Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. New England Journal of Medicine 1987;316(8):432-7.
15. O'Shea JS, Langenbrunner DJ, McCloskey DE, Pezzullo JC, Regan JB. Diagnostic and therapeutic studies in childhood serous otitis media. Results of treatment with an antihistamine-adrenergic combination. Annals of Otology, Rhinology, and Laryngology - Supplement 1980;89(3 Pt 2):285-9.
16. O'Shea JS, Langenbrunner DJ, McCloskey DE, Pezzullo JC, Regan JB. Childhood serous otitis media: fifteen months' observations of children untreated compared with those receiving an antihistamine-adrenergic combination. Clinical Pediatrics 1982;21(3):150-3.
17. Olson AL, Klein SW, Charney E, MacWhinney JB, Jr, McInerny TK, Miller RL, Nazarian LF, Cunningham D. Prevention and therapy of serous otitis media by oral decongestant: a double-blind study in pediatric practice. Pediatrics 1978;61(5):679-84.
18. Saunte C. Clinical trial with Lunerin mixture and Lunerin mite in children with secretory otitis media. Journal of International Medical Research 1978;6(1):50-5.
19. Altman JS, Haupert MS, Hamaker RA, Belenky WM. Phenylephrine and the prevention of postoperative tympanostomy tube obstruction. Archives of Otolaryngology - Head and Neck Surgery 1998;124(11):1233-6.
20. Bhambhani K, Foulds DM, Swamy KN, Eldis FE, Fischel JE. Acute otitis media in children: are decongestants or antihistamines necessary?. Annals of Emergency Medicine 1983;12(1):13-6.
21. Brown DT, Potsic WP, Marsh RR, Litt M. Drugs affecting clearance of middle ear secretions: a perspective for the management of otitis media with effusion. Annals of Otology, Rhinology, and Laryngology - Supplement 1985;117:3-15.
22. Brownoff R, Hutchison LJ. An Antihistamine Decongestant in the Prevention of Acute Otitis Media in Children with Colds. Can Fam Physician 1998;34:2389-93.
23. Cantekin EI, Bluestone CD, Rockette HE, Beery QC. Effect of decongestant with or without antihistamine on eustachian tube function. Annals of Otology, Rhinology, and Laryngology - Supplement 1980;89 (3Pt 2):290-5.
24. Chonmaitree T, Saeed K, Uchida T, Heikkinen T, Baldwin CD, Freeman DH, Jr, McCormick DP. A randomized, placebo-controlled trial of the effect of antihistamine or corticosteroid treatment in acute otitis media. Journal of Pediatrics 2003;143(3):377-85.
25. Collins MP, Church MK. The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media. Current Medical Research and Opinion 1983;8(4):392-4.
26. Gates GA, Wachtendorf C, Holt GR, Hearne EM. Medical treatment of chronic otitis media with effusion (secretory otitis media). Otolaryngology - Head and Neck Surgery 1986;94(3):350-4.
27. Grundfast KM. A review of the efficacy of systemically administered decongestants in the prevention and treatment of otitis media. Otolaryngology - Head and Neck Surgery 1981;89(3 Pt 1):432-9.
28. Kjellman NI, Harder H, Lindwall L, Synnerstad B. Longterm treatment with brompheniramine and phenylpropanolamine in recurrent otitis media - a double-blind study. Journal of Otolaryngology 1978;7(3):257-61.
29. Klein SW, Olson AL, Perrin J, Cunningham D, Hengerer A, Hoekelman RA, Roghmann KJ. Prevention and treatment of serous otitis media with an oral antihistamine. A double-blind study in pediatric practice. Clinical Pediatrics 1980;19(5):342-7.
30. Kraemer MJ, Marshall SG, Richardson MA. Etiologic factors in the development of chronic middle ear effusions. Clinical Reviews in Allergy 1984;2(4):319-28.
31. Lildholdt T, Cantekin EI, Bluestone CD, Rockette HE. Effect of a topical nasal decongestant on Eustachian tube function in children with tympanostomy tubes. Acta Oto Laryngologica 1982;94(1-2):93-7.
32. Malm L. Oral decongestants in acute rhinitis, acute sinusitis, acute otitis media and secretory otitis media: prognostic implications. Workshop: Treatment of Ear, Nose and Throat Infections 1985.
33. Marshall SG, Bierman CW, Shapiro GG. Otitis media with effusion in childhood. Annals of Allergy 1984;53(5):370-8, 394.
34. McCormick DP, Saeed K, Uchida T, Baldwin CD, Deskin R, Lett-Brown MA, Heikkinen T, Chonmaitree T. Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment. International Journal of Pediatric Otorhinolaryngology 2003;67(3):221-30.
35. Moller P. Negative middle ear pressure and hearing thresholds in secretory otitis media. A double-blind crossover study with Lunerin. Scandinavian Audiology 1980;9(3):171-6.
36. Moran DM, Mutchie KD, Higbee MD, Paul LD. The use of an antihistamine-decongestant in conjunction with an anti-infective drug in the treatment of acute otitis media. Journal of Pediatrics 1982;101(1):132-6.
37. Ogino S, Harada T, Matsunaga T, Tominaga Y. Use of Tranilast [N-(3,4-dimethoxycinnamoyl) anthranilic acid] in secretory otitismedia. Annals of Allergy 1992;68(5):407-12.
38. Otten FW, Grote JJ. Otitis media with effusion and chronic upper respiratory tract infection in children: a randomized, placebo-controlled clinical study. Laryngoscope 1990;100(6):627-33.
39. Sorri M, Sipila P. Can secretory otitis media be prevented by oral decongestants?. Acta Otolaryngologica Supplement 1982;386:115-6.
40. Suzuki M, Kawauchi H, Mogi G. Clinical efficacy of an antiallergic drug on otitismedia with effusion in association with allergic rhinitis. Auris Nasus Larynx 1999;26(2):123-9.
41. Theoharides TC, Manolidis SS, Vliagoftis H, Manolidis LS. Treatment of secretory otitis media with local instillation of hydroxyzine. International Archives of Allergy and Immunology 1994;103(1):95-101.
42. van Heerbeek N, Ingels KJ, Zielhuis GA. No effect of a nasal decongestant on eustachian tube function in children with ventilation tubes. Laryngoscope 2002;112(6):1115-8.
43. American Academy of Family Physicians, American Academy of Otolaryngology - Head, Neck Surgery. American Academy of Pediatrics Subcommittee on Otitis Media with Effusion. Otitis media with effusion. Pediatrics 2004;113(5):1412-29.
44. Bandolier Bias Guide. http://www.jr2.ox.ac.uk/bandolier/band80/b80-2.html 2000.
45. Barker FG, Carter BS. Synthesizing medical evidence: systematic reviews and meta-analyses. Neurosurg. Focus 2005;19(E5):1-21.
46. Berlin J. Does blinding of readers affect the results of meta-analyses?. Lancet 1997;350:185-6.
47. Bluestone CD, Klein JO. Otitis Media in Infants and Children. Second Edition. Philadephia: W.B. Saunders, 1995.
48. Fiellau-Nikolajsen M, Lous J, Pedersen SV, Schousboe HH. Tympanometry in three-year-old children. 1. A regional prevalence study on the distribution of tympanometric results in a non-selected population of three-year-old children. Scandinavian Audiology 1977;6:199-204.
49. Fiellau-Nikolajsen M, Lous J. Prospective tympanometry in three-year-old children: a study of spontaneous course of tympanometry types in a non-selected population. Archives of Otolaryngology 1979;105:461-6.
50. Fiellau-Nikolajsen M. Tympanometry and secretory otitis media. Observations on diagnosis, epidemiology, treatment, and prevention in prospective cohort studies of three-year-old children [thesis]. Acta Otolaryngologica Stockholm Supplement 1983;394:1-73.
51. Golz A Netzer A, Angel-Yeger B, Westerman ST, Gilbert LM, Joachims HZ. Effects of middle ear effusions on the vestibular system in children. Otolaryngology - Head and Neck Surgery 1998;119:695-9.
52. Grace AR, Pfleiderer AG. Dysequilibrium and otitis media with effusion: what is the association?. Journal of Laryngology and Otology 1990;104:682-4.
53. Jadad A, Moore R, Carroll D. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
54. Lexi-Drugs. http://www.cma.ca/index.cfm?la_id=1&ci_id= 370&gmAction=/lexidrug/displayMonograph.do&drugId=959 [accessed June 27, 2006].
55. Lous J, Fiellau-Nikolajsen M. Epidemiology of middle ear effusion and tubal dysfunction: a one-year prospective study comprising monthly tympanometry in 387 non-selected 7-year-old children. International Journal of Pediatric Otorhinolaryngology 1981;3:303-17.
56. Lous J. Secretory otitis media in schoolchildren. Is screening for secretory otitis media advisable?. Danish Medical Bulletin 1995;42:71-99.
57. Mohar D, Jadad AR, Nichol G. Assessing the quality of randomized controlled trials: An annotated bibliography of scales and checklists. Controlled Clinical Trials 1995;16:62-73.
58. Perera R, Glasziou P. Design Effect adjustment for paired data. (submitted to Statistics in Medicine) 2006.
59. Rosenfeld R, Bluestone C. Evidence Based Otitis Media. Hamilton, Ontario: BC Decker, 1999.
60. Shekelle P, Takata G, et al. Diagnosis, Natural History, and Late Effects of Otitis Media with Effusion. Evidence Report/Technology Assessment No. 55 (Prepared by Southern California Evidence-based Practice Center under Contract No 290-97-0001, Task Order No. 4). AHRQ Publication No. 03-E023. Rockville, MD: Agency for Healthcare Research and Quality May 2003.
61. Smucny J, Flynn C, Becker L, Glazier R. Beta2-agonists for acute bronchitis. In: The Cochrane Database of Systematic Reviews, 1, 2004. Chichester: John Wiley and Sons Ltd.
62. Takata GS, Chan LS, Morphew T, Mangione-Smith R, Morton SC, Shekelle P. Evidence assessment of the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion. Pediatrics 2003;112(6 Pt 1):1379-87.
63. Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. Journal of Infectious Diseases 1989;160:83-94.
64. Thomas CL, Simpson S, Butler CC, van der Voort JH. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. In: The Cochrane Database of Systematic Reviews, 3, 2006. Chichester: John Wiley and Sons Ltd.
65. Witmer A, Wells AM, Seymour RJ. A comparison of the effectiveness of pharmacologic treatment of otitis media with effusion in children: integrative and meta-analysis. Online Journal of Knowledge Synthesis for Nursing 1998; Vol. 5, issue 4.