The C-terminal domain of RNA polymerase II is modified by site-specific methylation

Science

Volumn 332, Issue 6025, 2011, Pages 99-103

  Sims III, Robert J ^a,c   Rojas, Luis Alejandro ^a   Beck, David ^a   Bonasio, Roberto ^a   Schüller, Roland ^b   Drury III, William J ^a   Eick, Dirk ^b   Reinberg, Danny ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Munich Center for Integrated Protein Science   (Germany)

^c Department of Structural Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1; PROTEIN ARGININE METHYLTRANSFERASE; RNA POLYMERASE II; SERINE; SMALL NUCLEAR RNA; SMALL NUCLEOLAR RNA; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA METHYLATION; TRANSCRIPTION INITIATION;

ANIMALS; ARGININE; CELL LINE; HELA CELLS; HUMANS; METHYLATION; MICE; MUTATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-ARGININE N-METHYLTRANSFERASES; RECOMBINANT PROTEINS; RNA POLYMERASE II; RNA, SMALL NUCLEAR; RNA, SMALL NUCLEOLAR;

MAMMALIA;

EID: 79953288782     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1202663     Document Type: Article

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20. These studies were supported by the HHMI (to D.R.) and grants from NIH (GM-37120 to D.R. and GM-71166 to R.J.S.). R.B. is a fellow of the Helen Hay Whitney foundation. D.E. was supported by Deutsche Forschungsgemeinschaft (SFB/Transregio-5, SFB684) and José Carreras Leukämie-Stiftung eV. We thank L. Vales, E. Lecona, and P. Voigt for careful reading of the manuscript; R. D. Chapman and K. Burger for technical support; and members of the Reinberg lab for critical commentaries during the development of this project. RNA-seq data have been deposited in the National Center for Biotechnology Information's Gene Expression Omnibus as GEO series GSE27315