Synthesis and biological evaluation of 4-styrylcoumarin derivatives as inhibitors of TNF-α and IL-6 with anti-tubercular activity

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2547-2549

  Upadhyay, Kuldip ^a   Bavishi, Abhay ^b   Thakrar, Shailesh ^b   Radadiya, Ashish ^b   Vala, Hardevsinh ^b   Parekh, Shrey ^b   Bhavsar, Dhairya ^b   Savant, Mahesh ^b   Parmar, Manisha ^b   Adlakha, Priti ^a   Shah, Anamik ^b  

^a Torrent Research Centre   (India)

^b SAURASHTRA UNIVERSITY   (India)

Author keywords

4 Styrylcoumarin; Anti inflammatory activity; Anti tubercular; IL 6; TNF

Indexed keywords

4 METHYLCOUMARIN 3 CARBONITRILE; 4 STYRYLCOUMARIN DERIVATIVE; 6 CHLORO 3 CYANO 4 STYRYLCOUMARIN DERIVATIVE; ACETIC ACID DERIVATIVE; ACETOPHENONE DERIVATIVE; ALDEHYDE; COUMARIN DERIVATIVE; INTERLEUKIN 6; TUBERCULOSTATIC AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROMETRY; INFRARED SPECTROSCOPY; KNOEVENAGEL CONDENSATION; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION;

ANTI-INFLAMMATORY AGENTS; ANTITUBERCULAR AGENTS; COUMARINS; INTERLEUKIN-6; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79953287138     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.016     Document Type: Article

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