High-risk HPV DNA status and P16(INK4A) expression as prognostic markers in patients with squamous cell cancer of oral cavity and oropharynx

Polish Journal of Pathology

Volumn 61, Issue 3, 2010, Pages 133-139

  Śnietura, Mirosław ^a   Jaworska, Magdalena ^a   Pigłowski, Wojciech ^a   Goraj Zajac, Aleksandra ^a   Woźniak, Grzegorz ^a   Lange, Dariusz ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

HNSCC; HPV; Oropharynx cancer; P16; PCR; Postoperative radiotherapy

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; TUMOR MARKER; VIRUS DNA;

ADJUVANT THERAPY; ARTICLE; ENZYME IMMUNOASSAY; GENETICS; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; METABOLISM; MORTALITY; MOUTH TUMOR; OROPHARYNX TUMOR; PAPILLOMAVIRUS INFECTION; POLYMERASE CHAIN REACTION; PROGNOSIS; SQUAMOUS CELL CARCINOMA; VIROLOGY;

CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, VIRAL; HUMAN PAPILLOMAVIRUS 16; HUMANS; IMMUNOENZYME TECHNIQUES; MOUTH NEOPLASMS; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; PROGNOSIS; RADIOTHERAPY, ADJUVANT; TUMOR MARKERS, BIOLOGICAL;

EID: 79953286061     PISSN: 12339687     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Decker J, Goldstein JC. Risk factors in head and neck cancer. N Engl J Med 1982; 306: 1151-1155.
2. Licitra L, Locati LD, Bossi P. Head and neck cancer. Ann Oncol 2004; 15 Suppl 4: iv267-273.
3. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and-unrelated oral squamous cell carcinomas in the United States. J Clin Oncol 2008; 26: 612-619.
4. Hammarstedt L, Lindquist D, Dahlstrand H, et al. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer 2006; 119: 2620-2623.
5. El-Mofty SK, Patil S. Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: 339-345.
6. Begum S, Cao D, Gillison M, Zahurak M, Westra WH. Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma. Clin Cancer Res 2005; 11: 5694-5699.
7. Klussmann JP, Mooren JJ, Lehnen M, et al. Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications. Clin. Cancer Res 2009; 15: 1779-1786.
8. Singhi AD, Stelow EB, Mills SE, Westra WH. Lymphoepithelial-like Carcinoma of the Oropharynx: A Morphologic Variant of HPV-related Head and Neck Carcinoma. Am J Surg Pathol 2010. Available at: http://www.ncbi.nlm.nih. gov/pubmed/20421782.
9. Ragin CCR, Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer 2007; 121: 1813-1820.
10. Worden FP, Kumar B, Lee JS, et al. Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number. J Clin Oncol 2008; 26: 3138-3146.
11. Suwiński R, Bańkowska-Woźniak M, Majewski W, et al. Randomized clinical trial on 7-days-a-week postoperative radiotherapy for high-risk squamous cell head and neck cancer. Radiother Oncol 2008; 87: 155-163.
12. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol. Biomarkers Prev 2005; 14: 467-475.
13. Badaracco G, Rizzo C, Mafera B, et al. Molecular analyses and prognostic relevance of HPV in head and neck tumours. Oncol Rep 2007; 17: 931-939.
14. Fakhry C, Westra WH, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008; 100: 261-269.
15. Lindel K, Beer KT, Laissue J, Greiner RH, Aebersold DM. Human papillomavirus positive squamous cell carcinoma of the oropharynx: a radiosensitive subgroup of head and neck carcinoma. Cancer 2001; 92: 805-813.
16. Begum S, Westra WH. Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol 2008; 32: 1044-1050.
17. Klozar J, Kratochvil V, Salakova M, et al. HPV status and regional metastasis in the prognosis of oral and oropharyngeal cancer. Eur Arch Otorhinolaryngol 2008; 265 Suppl 1: S75-82.
18. Snietura M, Jaworska M, Mlynarczyk-Liszka J, et al. PTEN as prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of head and neck. J Clin Oncol 2010; 28: 425.
19. Suwinski R, Jaworska M, Nikiel B, et al. Predicting the effect of accelerated fractionation in postoperative radiotherapy for head and neck cancer based on molecular marker profiles: data from a randomized clinical trial. Int J Radiat Oncol Biol Phys 2010; 77: 438-446.
20. Snijders PJF, van den Brule AJC, Meijer CJLM. The clinical relevance of human papillomavirus testing: relationship between analytical and clinical sensitivity. J Pathol 2003; 201: 1-6.
21. Smeets SJ, Hesselink AT, Speel EM, et al. A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 2007; 121: 2465-2472.
22. Li Y, Nichols MA, Shay JW, Xiong Y. Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res 1994; 54: 6078-6082.
23. Roussel MF. The INK4 family of cell cycle inhibitors in cancer. Oncogene 1999; 18: 5311-5317.
24. Hoffmann M, Ihloff AS, Görögh T, et al. p16(INK4a) overexpression predicts translational active human papillomavirus infection in tonsillar cancer. Int J Cancer 2010; Available at: http://www.ncbi.nlm.nih.gov/pubmed/20091864.
25. Pannone G, Santoro A, Bufo P, Papagerakis S, Lo Muzio L. The role of p16 as surrogate marker of HPV in oral squamous cell carcinomas. Analysis by tissue micro-array, immunohistochemistry and methylation-specific PCR. Eur Arch Otorhinolaryngol 2010; 267 (Suppl 1): S5.
26. Singhi AD, Westra WH. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer 2010; 116: 2166-2173.
27. Lassen P, Eriksen JG, Hamilton-Dutoit S, et al. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009; 27: 1992-1998.
28. Fischer CA, Kampmann M, Zlobec I, et al. p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters. Ann Oncol 2010. Available at: http://www.ncbi.nlm.nih. gov/pubmed/20423915.