Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway

Phytochemistry

Volumn 72, Issue 7, 2011, Pages 645-650

  Giordani, Raquel Brandt ^a   De Brum Vieira, Patrícia ^a   Weizenmann, Marina ^a   Rosemberg, Denis Broock ^a   Souza, Ana Paula ^b   Bonorino, Cristina ^b   De Carli, Geraldo Attilio ^b   Bogo, Maurício Reis ^b   Zuanazzi, José Angelo ^a   Tasca, Tiana ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Alkaloids; Amaryllidaceae; Amitochondriate; Cell death pathway; Hippeastrum santacatarina; Lycorine; Parasite; Trichomonas vaginalis

Indexed keywords

AMARYLLIDACEAE ALKALOID; LYCORINE; PHENANTHRIDINE DERIVATIVE;

ARTICLE; CELL CYCLE; CELL DEATH; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; TRANSMISSION ELECTRON MICROSCOPY; TRICHOMONAS VAGINALIS; ULTRASTRUCTURE;

AMARYLLIDACEAE ALKALOIDS; CELL CYCLE; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROSCOPY, ELECTRON, TRANSMISSION; PHENANTHRIDINES; TRICHOMONAS VAGINALIS;

AMARYLLIDACEAE; ARCHEZOA; HIPPEASTRUM; TRICHOMONAS VAGINALIS;

EID: 79953284435     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2011.01.023     Document Type: Article

References (34)

1. O. Arrigoni, R. Liso, and G. Calabrese Lycorine as an inhibitor of ascorbic acid biosynthesis Nature 256 1975 513 514
2. M. Benchimol Trichomonads under microscopy Microsc. Microanal. 10 2004 528 550 (Pubitemid 39404017)
3. K.P. Carvalho, and A.P. Gadelha Effects of three benzimidazoles on growth, general morphology and structure of Trichomonas foetus FEMS Microbiol. Lett. 275 2007 292 300 (Pubitemid 47437865)
4. O. Chose, C. Nöel, D. Gerbod, C. Brenner, E. Viscogliosi, and A. Roseto A form of cell death with some features resembling apoptosis in the amitochondrial unicellular organism Trichomonas vaginalis Exp. Cell Res. 276 2002 29 32
5. O. Chose, C. Sarde, D. Gerbod, E. Viscogliosi, and A. Roseto Programmed cell death in parasitic protozoans that lack mitochondria Trends Parasitol. 19 2003 559 564 (Pubitemid 37464803)
6. G. Citoglu, M. Tanker, and B. Gamusel Antiinflammatory effects of lycorine and haemanthidine Phytother. Res. 12 1998 205 206
7. M.F. Cotch, J.G. Pastorek, R.P. Nugent, S.L. Hillier, R.S. Gibbs, D.H. Martin, D.A. Eschenbach, R. Edelman, J.C. Carey, J.A. Regan, M.A. Krohn, A.V. Rao, and G.G. Rhoads Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group Sex. Transm. Dis. 24 1997 353 360 (Pubitemid 27306585)
8. L. Del Giudice, D.R. Massardo, P. Pontieri, and K. Wolf Interaction between yeast mitochondrial and nuclear genomes: null alleles of RTG genes affect resistance to the alkaloid lycorine on cell division and cell elongation Gene 354 2005 9 14 (Pubitemid 41116675)
9. L.S. Diamond The establishment of various Trichomonas of animals and man in axenic cultures J. Parasitol. 43 1957 488 490
10. A. Evidente, and G. Randazzo Degradation of lycorine by Pseudomonas species strain ITM 311 J. Nat. Prod. 48 1985 564 570 (Pubitemid 16228201)
11. R.B. Giordani, L.B. Pagliosa, A.T. Henriques, J.E. Dutilh, and J.A.S. Zuanazzi Investigaão do potencial antioxidante e anticolinesterá sico de Hippeastrum (Amaryllidaceae) Quim. Nova 31 2008 2042 2046
12. F. Grodstein, M.B. Goldman, and D.W. Cramer Relation of tubal infertility to history of sexually transmitted diseases Am. J. Epidemiol. 137 1993 577 584 (Pubitemid 23109759)
13. A. Jimenez, A. Santos, G. Alonso, and D. Vazquez Inhibitors of protein síntesis in eukaryotics cells: comparative effects of some Amaryllidaceae alkaloids Biochim. Biophys. Acta 435 1976 342 348
14. V.J. Johnston, and D.C. Mabey Global epidemiology and control of Trichomonas vaginalis Curr. Opin. Infect. Dis. 21 2008 56 64
15. G. Kroemer, and B. Levine Autophagic cell death: the history of a misnomer Nat. Rev. Mol. Cell Biol. 9 2008 1004 1010
16. D. Lamoral-Theys, A. Andolfi, V.G. Gwendoline, A. Cimmino, B. Le Calv, N. Wauthoz, V. Mégalizzi, T. Gras, Bruyre, J. Dubois, V. Mathieu, A. Kornienko, R. Kiss, and A. Evidente Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to pro-apoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight J. Med. Chem. 52 2009 6244 6256
17. R. Li, and X. Tan Identification of natural compounds with antiviral activities against SARS-associated coronavirus Antiviral Res. 67 2005 18 23 (Pubitemid 40798914)
18. S. Li, C. Chen, H. Zhang, H. Guo, H. Wang, L. Wang, X. Zhang, S. Hua, J. Yu, P. Xiao, Y. Li, J. Liu, L. Tang, Y. Shi, W. Ren, and W. Hu Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest Oncol. Rep. 17 2007 377 384
19. J. Liu, W. Hu, L. He, M. Ye, and Y. Li Effects of lycorine on HL-60 cells via arresting cell cycle and inducing apoptosis FEBBS Lett. 578 2004 245 250 (Pubitemid 39601789)
20. X.S. Liu, J. Jiang, X.Y. Jiao, Y.E. Wu, J.H. Lin, and Y.M. Cai Lycorine induces apoptosis and down regulation of MCL-1 in human leukemia cells Cancer Lett. 274 2009 16 24
21. S. Lopez, J. Bastida, F. Viladomat, and C. Codina Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts Life Sci. 71 2002 2521 2529 (Pubitemid 35247960)
22. R.F. Madeiro da Costa, and M. Benchimol The effect of drugs in T. foetus Parasitol. Res. 92 2004 159 170
23. J. McNulty, J.J. Nair, J. Bastida, S. Pandey, and C. Griffin Structure-activity studies on the lycorine pharmacophore: a potent inducer of apoptosis in human leukemia cells Phytochemistry 70 2009 913 919
24. R. Michel, F. Borges, R. Wiltuschnig, F. Neves, J. Ribeiro, R. Vieiro, P.B. Vieira, G. Bohns, T. Tasca, and G.A. De Carli Prevalência da tricomonose em mulheres residentes na Vila dos Papeleiros em Porto Alegre, RS RBAC 38 2006 127 130
25. M. Müller The hydrogenosome J. Gen. Microbiol. 139 1993 2879 2889
26. K. Ofer, D. Gold, and E. Flescher Methyl jasmonate induces cell cycle block and cell death in the amitochondriate parasite Trichomonas vaginalis Int. J. Parasitol. 38 2008 959 968
27. R.A. Olie, F. Durrieu, S. Cornillon, G. Loughran, J. Gross, W.C. Earnshaw, and P. Golstein Apparent caspase independence of programmed cell death in Dictyostelium Curr. Biol. 8 1998 955 958 (Pubitemid 28447944)
28. S. Sperandio, I. da Belle, and D.E. Bredsen An alternative, nonapoptotic form of programmed cell death PNAS 97 2000 14376 14381 (Pubitemid 32016583)
29. T. Tasca, C.D. Bonan, G.A. De Carli, and J.J. Sarkis Trichomonas vaginalis: cytochemical localization of a NTPDase1 and an ecto-5'-nucleotidase and effects of adenine nucleotides on cellular viability Parasitol. Res. 93 2004 300 303 (Pubitemid 39044230)
30. N. Unver New skeletons and new concepts in Amaryllidaceae alkaloids Phytochem. Rev. 6 2007 125 135 (Pubitemid 46457323)
31. M. Viiki, E. Pukkala, P. Nieminen, and M. Hakama Gynaecological infections as risk determinants of subsequent cervical neoplasia Acta Oncol. 39 2000 71 75 (Pubitemid 30216619)
32. T.A. Weirnet, and L.H. Hartwell Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts post translationary in cell cycle arrest after DNA damage Mol. Cell. Biol. 10 1990 6554 6564 (Pubitemid 120004599)
33. WHO Global Prevalence and Incidence of Selected Curable Sexually Transmitted Infections. Overview and Estimates 2001 World Health Organization Geneva, Switzerland
34. J. Zhong Amaryllidaceae and Sceletium alkaloids Nat. Prod. Rep. 22 2005 111 126