Methyl jasmonate induces cell cycle block and cell death in the amitochondriate parasite Trichomonas vaginalis

International Journal for Parasitology

Volumn 38, Issue 8-9, 2008, Pages 959-968

  Ofer, Kinneret ^a   Gold, Daniel ^a   Flescher, Eliezer ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Apoptosis; Cell cycle arrest; DNA fragmentation; Drug resistant T. vaginalis; Jasmonates; Mitochondria; Refractory trichomoniasis; Trichomonas vaginalis

Indexed keywords

CASPASE 3; DEOXYGLUCOSE; JASMONIC ACID METHYL ESTER; METRONIDAZOLE;

APOPTOSIS; BIOENERGETICS; CANCER; CHEMICAL DEFENSE; DAMAGE; DNA; FLAGELLATE; GLUCOSE; HOMEOSTASIS; LIPID; MITOCHONDRION; MORTALITY; ORGANIC COMPOUND; TOXICITY;

ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOENERGY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG POTENTIATION; ENZYME ACTIVATION; HOMEOSTASIS; MITOCHONDRION; NONHUMAN; PROTEIN DEPLETION; TRICHOMONAS VAGINALIS;

ACETIC ACIDS; ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; CELL CYCLE; CYCLOPENTANES; HUMANS; METRONIDAZOLE; MICE; MITOCHONDRIA; OXYLIPINS; PLANT GROWTH REGULATORS; TRICHOMONAS VAGINALIS;

ARCHEZOA; MASTIGOPHORA (FLAGELLATES); PLASMODIUM FALCIPARUM; SCHISTOSOMA MANSONI; TRICHOMONAS VAGINALIS;

EID: 43849101207     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2007.12.008     Document Type: Article

References (31)

1. Banuelos A., Reyes E., Ocadiz R., Alvarez E., Moreno M., Monroy A., and Gariglio P. Neocarzinostatin induces an effective p53-dependent response in human papillomavirus-positive cervical cancer cells. J. Pharm. Exp. Ther. 306 (2003) 671-680
2. Bliss C.I. The toxicity of poisons applied jointly. Ann. Appl. Biol. 26 (1939) 585-615
3. Carlton J.M., et al. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science 315 (2007) 207-211
4. Centers for Disease Control and Prevention, Workowski K.A., and Berman S.M. Sexually transmitted diseases treatment guidelines 2006. MMWR Recomm. Rep. 55 (2006) 1-94
5. Chose O., Noel C., Gerbod D., Brenner C., Viscogliosi E., and Roseto A. A form of cell death with some features resembling apoptosis in the amitochondrial unicellular organism Trichomonas vaginalis. Exp. Cell Res. 276 (2002) 32-39
6. Chose O., Sarde CO., Gerbod D., Viscogliosi E., and Roseto A. Programmed cell death in parasitic protozoans that lack mitochondria. Trends Parasitol. 19 (2003) 559-564
7. Crowell A.L., Sanders-Lewis K.A., and Secor E. In-vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis. Antimicrob. Agents Chemoth. 47 (2003) 1407-1409
8. Cudmore S.L., Delgaty K.L., Hayward-McClelland S.F., Petrin D.P., and Garber G.E. Treatment of infections caused by metronidazole-resistant Trichomonas vaginalis. Clin. Microbiol. Rev. 17 (2004) 783-793
9. Diamond L.S., Harlow D.R., and Cunnick C.C. A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba. Trans. R. Soc. Trop. Med. Hyg. 72 (1978) 431-432
10. Embley T.M., and Martin M. Eukaryotic evolution, changes and challenges. Nature 440 (2006) 623-630
11. Fingrut O., and Flescher E. Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells. Leukemia 16 (2002) 608-616
12. Fingrut O., Reischer D., Rotem R., Goldin N., Altboum I., Zan-Bar I., and Flescher E. Jasmonates induce non-apoptotic death in high-resistance mutant p53-expressing B lymphoma cells. Br. J. Pharmacol. 146 (2005) 800-808
13. Flescher E. Jasmonates - a new family of anti-cancer agents. Anti-Cancer Drugs 16 (2005) 911-916
14. Flescher E. Jasmonates in cancer therapy. Cancer Lett. 245 (2007) 1-10
15. Garcia L.S. Diagnostic Medical Parasitology. fourth ed. (2001), ASM Press, Washington, DC (pp. 120-127)
16. Gold D., and Ofek I. Adhesion of Trichomonas vaginalis to plastic surfaces: requirement for energy and serum constituents. Parasitology 105 (1992) 55-62
17. Gold D., Pankova-Kholmyansky I., Fingrut O., and Flescher E. The anti-parasitic actions of plant jasmonates. J. Parasitol. 89 (2003) 1242-1244
18. Goldin N., Heyfets A., Reischer D., and Flescher E. Mitochondria-mediated ATP depletion by anti-cancer agents of the jasmonate family. J. Bioenerg. Biomembr. 39 (2007) 51-57
19. Gonzalez I.J., Desponds C., Schaff C., Mottram J.C., and Fasel N. Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity. Int. J. Parasitol. 37 (2007) 161-172
20. Heyfets A., and Flescher E. Cooperative cytotoxicity of methyl jasmonate with anti-cancer drugs and 2-deoxy-d-glucose. Cancer Lett. 250 (2007) 300-310
21. Marinate R.M., Guimaraes C.A., Linden R., and Benchimol M. Hydrogen peroxide induces caspase activation and programmed cell death in the amitochondrial Trichomonas foetus. Histochem. Cell Biol. 120 (2003) 129-141
22. Markell E.K., John D.T., and Krotoski W.A. Markell and Voge's Medical Parasitology. eighth ed. (1999), W.B. Saunders Company, Philadelphia (pp. 64-67)
23. Mazet M., Diogon M., Alderete J.F., Vivares C.P., and Delbac F. First molecular characterization of hydrogenosomes in the protozoan parasite Histomonas meleagridis. Int. J. Parasitol. 38 2 (2008) 177-190
24. Muller M. The hydrogenosome. J. Gen. Microbiol. 39 (1993) 2879-2889
25. Narcisi E.M., and Secor W.E. In-vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis. Antimicrob. Agents Chemother. 40 (1996) 1121-1125
26. Pankova-Kholmyansky I., Dagan A., Gold D., Zaslavsky Z., Skutelsky E., Gatt S., and Flescher E. Ceramide mediates growth inhibition of the Plasmodium falciparum parasite. Cell. Mol. Life Sci. 60 (2003) 577-587
27. Petrin D., Delgaty K., Bhatt R., and Garber G. Clinical and microbiological aspects of Trichomonas vaginalis. Clin. Microbiol. Rev. 11 (1998) 300-317
28. Reischer D., Heyfets A., Shimony S., Nordenberg J., Kashman Y., and Flescher E. Effects of natural and novel synthetic jasmonates in an experimental metastasis model. Br. J. Pharmacol. 150 (2007) 738-749
29. Riley D.E., Krieger J.N., Miner D., and Rabinovitch P.S. Trichomonas vaginalis: dominant G2 period and G2 phase arrest in a representative of an early branching eukaryotic lineage. J. Eukaryot. Microbiol. 41 (1994) 408-414
30. Rotem R., Heyfets A., Fingrut O., Blickstein D., Shaklai M., and Flescher E. Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria. Cancer Res. 65 (2005) 1984-1993
31. Schwebke J.R., and Barrientes F.J. Prevalence of Trichomonas vaginalis isolates with resistance to metronidazole and tinidazole. Antimicrob. Agents Chemother. 50 (2006) 4209-4210