In vitro synergism of trifluorothymidine and ganciclovir against HSV-1

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 2, 2011, Pages 830-833

  Hobden, Jeffery A ^a   Kumar, Manish ^a,b   Kaufman, Herbert E ^a,c   Clement, Christian ^a   Varnell, Emily D ^a   Bhattacharjee, Partha S ^d   Hill, James M ^a,c  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d XAVIER UNIVERSITY OF LOUISIANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; TRIFLURIDINE; ANTIVIRUS AGENT;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG POTENCY; HERPES SIMPLEX VIRUS 1; IC 50; IN VITRO STUDY; NONHUMAN; PLAQUE FORMING CELL; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS STRAIN; ANIMAL; CERCOPITHECUS; DRUG EFFECT; DRUG POTENTIATION; GROWTH, DEVELOPMENT AND AGING; VERO CELL; VIRUS CULTURE;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DRUG SYNERGISM; GANCICLOVIR; HERPESVIRUS 1, HUMAN; PLAQUE ASSAY; TRIFLURIDINE; VERO CELLS; VIRUS CULTIVATION;

EID: 79953278781     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5671     Document Type: Article

References (29)

1. Liesegang TJ. Herpes simplex virus epidemiology and ocular importance. Cornea. 2001;20:1-13.
2. Whitley RJ, Roizman B. Herpes simplex viruses. In: Richman DD, Whitley RJ, Hayden FG, eds. Clinical Virology. Washington, DC: ASM Press; 2009:409-436.
3. Kaufman HE, Rayfield MA, Gebhardt BM. Herpes simplex infections. In: Kaufman HE, Barron BA, McDonald MB, eds. The Cornea. Boston: Butterworth-Heinemann; 1998:247-277.
4. Bijnsdorp IV, Kruyt FA, Gokoel S, et al. Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent. Cancer Sci. 2008;99:2302-2308.
5. Roizman B, Knipe DM, Whitley RJ. Herpes simplex viruses. In: Knipe DM, Howley PM, eds. Fields Virology. 5th ed. Baltimore: Lippincott Williams & Wilkins; 2007:2503-2602.
6. Castela N, Vermerie N, Chast F, et al. Ganciclovir ophthalmic gel in herpes simplex virus rabbit keratitis: intraocular penetration and efficacy. J Ocul Pharmacol. 1994;10:439-451.
7. Kaufman HE, Varnell ED, Thompson HW. Trifluridine, cidofovir, and penciclovir in the treatment of experimental herpetic keratitis. Arch Ophthalmol. 1998;116:777-780.
8. Sanitato JJ, Asbell PA, Varnell ED, et al. Acyclovir in the treatment of herpetic stromal disease. Am J Ophthalmol. 1984;98:537-547.
9. Wellings PC, Awdry PN, Bors FH, et al. Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers. Am J Ophthalmol. 1972;73:932-942.
10. Colin J, Hoh HB, Easty DL, et al. Ganciclovir ophthalmic gel (Zirgan; 0.15%) in the treatment of herpes simplex keratitis. Cornea. 1997;16:393-399.
11. Duan R, de Vries RD, Osterhaus AD, et al. Acyclovir-resistant corneal HSV-1 isolates from patients with herpetic keratitis. J Infect Dis. 2008;198:659-663.
12. Yin MT, Brust JCM, Tieu HV, et al. Anti-herpes virus, anti-hepatitis virus, and anti-respiratory virus agents. In: Richman DD, Whitley RJ, Hayden FG, eds. Clinical Virology. Washington, DC: ASM Press; 2009:409-436.
13. Griffiths A, Coen DM. High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant. J Virol. 2003;77:2282-2286.
14. Sato A, Linehan MM, Iwasaki A. Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Nat Acad Sci U S A. 2006;103:17343-17348.
15. Kaye S, Choudhary A. Herpes simplex virus. Prog Ret Eye Res. 2006;25:355-380.
16. National Committee for Clinical Laboratory Standards. Antiviral Susceptibility Testing: Herpes Simplex Virus by Plaque Reduction Assay; Approved Standard, M33-A. Wayne, PA: NCCLS; 2004.
17. Greco WR, Bravo G, Parsons JC. The search for synergy: a critical review from a response surface perspective. Pharmacol Rev. 1995;47:331-385.
18. Odds FC. Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother. 2003;52:1.
19. Kaufman HE, Varnell ED, Gebhardt BM, et al. Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection. J Ocul Pharmacol Ther. 2008;24:34-42.
20. Carmine AA, Brogden RN, Heel RC, et al. Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections. Drugs. 1982;23:329-353.
21. Power WJ, Benedict-Smith A, Hillery M, et al. Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymi-dine (TFT) in dendritic corneal ulceration. Br J Ophthalmol. 1991; 75:649-651.
22. Van Bijsterveld OP, Post H. Trifluorothymidine versus adenine arabinoside in the treatment of herpes simplex keratitis. Br J Ophthalmol. 1980;64:33-36.
23. Hayden FG. Antiviral agents (non-retroviral). In: Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. New York: McGraw-Hill; 2006:1243-1272.
24. Marcelletti JF. Synergistic inhibition of herpesvirus replication by docosanol and antiviral nucleoside analogs. Antiviral Res. 2002; 56:153-166.
25. Birch CJ, Tyssen DP, Tachedjian G, et al. Clinical effects and in vitro studies of trifluorothymidine combined with interferon-alpha for treatment of drug-resistant and -sensitive herpes simplex virus infections. J Infect Dis. 1992;166:108-112.
26. Chen Z, Song J, Chen K. Anti-herpes simplex virus action of combined therapy with cyclocytidine and ganciclovir [in Chinese]. Zhonghua Yan Ke Za Zhi. 1996;32:25-28.
27. Morfin F, Thouvenot D. Herpes simplex virus resistance to antiviral drugs. J Clin Virol. 2003;26:29-37.
28. Duan R, de Vries RD, van Dun, et al. Acyclovir susceptibility and genetic characteristics of sequential herpes simplex virus type 1 corneal isolates from patients with recurrent herpetic keratitis. J Infect Dis. 2009;200:1402-1414.
29. Ziyaeyan M, Alborzi A, Japoni A, et al. Frequency of acyclovir-resistant herpes simplex viruses isolated from the general immu-nocompetent population and patients with acquired immunodeficiency syndrome. Int J Dermatol. 2007;1263-1266.