A novel platelet glycoprotein Ib-binding protein with human platelet aggregation-inhibiting activity from Trimeresurus jerdonii venom

Toxicon

Volumn 57, Issue 5, 2011, Pages 672-679

  Chen, ZhongMing ^a,b   Wu, JianBo ^a   Zhang, Yong ^a   Yang, XingWang ^a,b   Yu, GuoYu ^a,b   Zhu, ShaoWen ^a   Lee, WenHui ^a   Lu, QiuMing ^a   Zhang, Yun ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Glycoprotein Ib binding; Inhibition; Jerdonibitin; Molecular cloning; Platelet aggregation; Purification

Indexed keywords

ANTITHROMBOCYTIC AGENT; COMPLEMENTARY DNA; DODECYL SULFATE SODIUM; GLYCOPROTEIN IB; GLYCOPROTEIN IB ALPHA; JERDONIBITIN; LECTIN; RISTOCETIN; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA CHAIN; CHROMOSOME BAND; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFECT; DRUG MECHANISM; DRUG PURIFICATION; HUMAN; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR CLONING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POISONOUS SNAKE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE COUNT; THROMBOCYTE RICH PLASMA; THROMBOCYTOPENIA; TRIMERESURUS JERDONII;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; CROTALID VENOMS; DNA FINGERPRINTING; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; LECTINS, C-TYPE; MOLECULAR SEQUENCE DATA; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MUS; TRIMERESURUS JERDONII;

EID: 79953269375     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.01.010     Document Type: Article

References (36)

1. Andrews R.K., Kroll M.H., Ward C.M., Rose J.W., Scarborough R.M., Smith A.I., Lopez J.A., Berndt M.C. Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex. Effect on platelet aggregation and glycoprotein Ib-mediated platelet activation. Biochemistry 1996, 35:12629-12639.
2. Chan J.C., Kwok M.M., Cockram C.S., Prematilleke M.N., Tomlinson B., Critchley J.A. Blood coagulation abnormalities associated with envenoming by Trimeresurus albolabris in Hong Kong. Singapore Med. J. 1993, 34:145-147.
3. Chen R.Q., Jin Y., Wu J.B., Zhou X.D., Lu Q.M., Wang W.Y., Xiong Y.L. A new protein structure of P-II class snake venom metalloproteinases: it comprises metalloproteinase and disintegrin domains. Biochem. Biophys. Res. Commun. 2003, 310:182-187.
4. Clemetson K.J. Snaclecs (snake C-type lectins) that inhibit or activate platelets by binding to receptors. Toxicon 2010, 56:1236-1246.
5. Clemetson J.M., Polgar J., Magnenat E., Wells T.N., Clemetson K.J. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. J. Biol. Chem. 1999, 274:29019-29024.
6. Clemetson K.J., Lu Q., Clemetson J.M. Snake C-type lectin-like proteins and platelet receptors. Pathophysiol. Haemost. Thromb. 2005, 34:150-155.
7. De Marco L., Mazzucato M., Masotti A., Fenton J.W., Ruggeri Z.M. Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin. J. Biol. Chem. 1991, 266:23776-23783.
8. De Marco L., Mazzucato M., Masotti A., Ruggeri Z.M. Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. J. Biol. Chem. 1994, 269:6478-6484.
9. Francischetti I.M. Platelet aggregation inhibitors from hematophagous animals. Toxicon 2010, 56:1130-1144.
10. Fukuda K., Mizuno H., Atoda H., Morita T. Crystal structure of flavocetin-A, a platelet glycoprotein Ib-binding protein, reveals a novel cyclic tetramer of C-type lectin-like heterodimers. Biochemistry 2000, 39:1915-1923.
11. 2+ responses of protease-treated human platelets activated with alpha-thrombin and the tethered ligand peptide. Biochemistry 1996, 35:915-921.
12. Hirotsu S., Mizuno H., Fukuda K., Qi M.C., Matsui T., Hamako J., Morita T., Titani K. Crystal structure of bitiscetin, a von Willebrand factor-dependent platelet aggregation inducer. Biochemistry 2001, 40:13592-13597.
13. Huang K.F., Ko T.P., Hung C.C., Chu J., Wang A.H., Chiou S.H. Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem. J. 2004, 378:399-407.
14. Jasti J., Paramasivam M., Srinivasan A., Singh T.P. Crystal structure of echicetin from Echis carinatus (Indian saw-scaled viper) at 2.4 A resolution. J. Mol. Biol. 2004, 335:167-176.
15. Kawasaki T., Fujimura Y., Usami Y., Suzuki M., Miura S., Sakurai Y., Makita K., Taniuchi Y., Hirano K., Titani K. Complete amino acid sequence and identification of the platelet glycoprotein Ib-binding site of jararaca GPIb-BP, a snake venom protein isolated from Bothrops jararaca. J. Biol. Chem. 1996, 271:10635-10639.
16. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
17. Lee W.H., Zhang Y. Molecular cloning and characterization of a platelet glycoprotein Ib-binding protein from the venom of Trimeresurus stejnegeri. Toxicon 2003, 41:885-892.
18. Lee W.H., Du X.Y., Lu Q.M., Clemetson K.J., Zhang Y. Stejnulxin, a novel snake C-type lectin-like protein from Trimeresurus stejnegeri venom is a potent platelet agonist acting specifically via GPVI. Thromb. Haemost. 2003, 90:662-671.
19. Lova P., Campus F., Lombardi R., Cattaneo M., Sinigaglia F., Balduini C., Torti M. Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin. J. Biol. Chem. 2004, 279:25299-25306.
20. Lu Q.M., Jin Y., Li D.S., Wang W.Y., Xiong Y.L. Characterization of a thrombin-like enzyme from the venom of Trimeresurus jerdonii. Toxicon 2000, 38:1225-1236.
21. Lu Q., Navdaev A., Clemetson J.M., Clemetson K.J. GPIb is involved in platelet aggregation induced by mucetin, a snake C-type lectin protein from Chinese habu (Trimeresurus mucrosquamatus) venom. Thromb. Haemost. 2004, 91:1168-1176.
22. Maita N., Nishio K., Nishimoto E., Matsui T., Shikamoto Y., Morita T., Sadler J.E., Mizuno H. Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins. J. Biol. Chem. 2003, 278:37777-37781.
23. Navdaev A., Dormann D., Clemetson J.M., Clemetson K.J. Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMkappa responsible for platelet agglutination in plasma and inducing signal transduction. Blood 2001, 97:2333-2341.
24. Packham M.A. Role of platelets in thrombosis and hemostasis. Can. J. Physiol. Pharmacol. 1994, 72:278-284.
25. Peng M., Lu W., Kirby E.P. Alboaggregin-B: a new platelet agonist that binds to platelet membrane glycoprotein Ib. Biochemistry 1991, 30:11529-11536.
26. Rivera J., Lozano M.L., Navarro-Nunez L., Vicente V. Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 2009, 94:700-711.
27. Rucavado A., Soto M., Kamiguti A.S., Theakston R.D., Fox J.W., Escalante T., Gutierrez J.M. Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage. Thromb. Haemost. 2001, 85:710-715.
28. Sakurai Y., Fujimura Y., Kokubo T., Imamura K., Kawasaki T., Handa M., Suzuki M., Matsui T., Titani K., Yoshioka A. The cDNA cloning and molecular characterization of a snake venom platelet glycoprotein Ib-binding protein, mamushigin, from Agkistrodon halys blomhoffii venom. Thromb. Haemost. 1998, 79:1199-1207.
29. Shin Y., Okuyama I., Hasegawa J., Morita T. Molecular cloning of glycoprotein Ib-binding protein, flavocetin-A, which inhibits platelet aggregation. Thromb. Res. 2000, 99:239-247.
30. Suzuki-Inoue K., Fuller G.L., Garcia A., Eble J.A., Pohlmann S., Inoue O., Gartner T.K., Hughan S.C., Pearce A.C., Laing G.D., Theakston R.D., Schweighoffer E., Zitzmann N., Morita T., Tybulewicz V.L., Ozaki Y., Watson S.P. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 2006, 107:542-549.
31. Taniuchi Y., Kawasaki T., Fujimura Y. The high molecular mass, glycoprotein Ib-binding protein flavocetin-A induces only small platelet aggregates in vitro. Thromb. Res. 2000, 97:69-75.
32. Usami Y., Suzuki M., Yoshida E., Sakurai Y., Hirano K., Kawasaki T., Fujimura Y., Titani K. Primary structure of alboaggregin-B purified from the venom of Trimeresurus albolabris. Biochem. Biophys. Res. Commun. 1996, 219:727-733.
33. Wei Q., Lu Q.M., Jin Y., Li R., Wei J.F., Wang W.Y., Xiong Y.L. Purification and cloning of a novel C-type lectin-like protein with platelet aggregation activity from Trimeresurus mucrosquamatus venom. Toxicon 2002, 40:1331-1338.
34. Yip J., Shen Y., Berndt M.C., Andrews R.K. Primary platelet adhesion receptors. IUBMB Life 2005, 57:103-108.
35. Zha H.G., Lee W.H., Zhang Y. Cloning of cDNAs encoding C-type lectins from Elapidae snakes Bungarus fasciatus and Bungarus multicinctus. Toxicon 2001, 39:1887-1892.
36. Zhou X.D., Jin Y., Chen R.Q., Lu Q.M., Wu J.B., Wang W.Y., Xiong Y.L. Purification, cloning and biological characterization of a novel disintegrin from Trimeresurus jerdonii venom. Toxicon 2004, 43:69-75.