Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage

Thrombosis and Haemostasis

Volumn 85, Issue 4, 2001, Pages 710-715

  Rucavado, A ^a   Soto, M ^a   Kamiguti, A S ^a   Theakston, R D G ^a   Fox, J W ^a   Escalante, T ^a   Gutierrez J M ^a  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

Aspercetin; Bothrops asper venom; C type lectin; Hemorrhage; Platelet aggregation; Thrombocytopenia

Indexed keywords

ASPERCETIN; GLYCOPROTEIN IB; LECTIN; METALLOPROTEINASE; SNAKE VENOM; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

AFFINITY CHROMATOGRAPHY; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BLEEDING; BLEEDING TIME; CELL AGGLUTINATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EDEMA; ENVENOMATION; FUNCTION TEST; ION EXCHANGE CHROMATOGRAPHY; ISOLATION PROCEDURE; MASS SPECTROMETRY; MOUSE; MUSCLE NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; SNAKEBITE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TOXIN ANALYSIS; TOXIN STRUCTURE;

EID: 0035067692     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615657     Document Type: Article

References (33)

1. Snake venoms and the hemostatic system
2. Snake venoms affecting the haemostatic mechanism - A consideration of their mechanisms, practical applications and biological significance
3. Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in São Paulo, Brazil
4. A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia
5. Clinical toxicology of snakebite in Africa and the Middle East/Arabian Peninsule
6. Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors
7. Snake venom C-type lectins as tools in platelet research
8. Hemorrhagic toxins from rattlesnake (Crotalus atrox) venom: Pathogenesis of hemorrhage induced by three purified toxins
9. Hemorrhagic metalloproteinases from snake venoms
10. Clinical toxicology of snake bites in Central America
11. Host response to Bothrops asper snake venom: Analysis of edema formation, inflammatory cells and cytokine release in a mouse model
12. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
13. The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase
14. Inhibition of collagen-induced platelet aggregation as the result of cleavage of alpha 2 beta 1-integrin by the snake venom metalloproteinase jararhagin
15. Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper)
16. A novel blood coagulation factor IX/factor X-binding protein with anticoagulant activity from the venom of Trimeresurus flavoviridis (habu snake): Isolation and characterization
17. Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper
18. Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom
19. Mionecrosis, hemorragia y edema inducidos por el veneno de Bothrops asper en ratón blanco
20. A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis
21. Isolation and characterization of a metalloproteinase with weak hemorhagic activity from the venom of the snake Bothrops asper (terciopelo)
22. Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper
23. Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex
24. C-type galactoside-binding lectin from Bothrops jararaca venom: Comparison of its structure and function with those of botrocetin
25. Isolation and characterization of an anti-coagulant protein homologous to botrocetin from the venom of Bothrops jararaca
26. A novel blood coagulation factor IX/factor X-binding protein with anticoagulant activity from the venom of Trimeresurus flavoviridis (habu snake): Isolation and characterization
27. Complete amino acid sequence and identification of the platelet glycoprotein Ib-binding site of jararaca GPIb-BP, a snake venom protein isolated from B. jararaca
28. Alboaggregins A and B. Structure and interaction with human platelets
29. Purification and characterization of bitiscetin, a novel von Willebrand factor modulator protein from Bitis arietans snake venom
30. Von Willebrand syndrome induced by a Bothrops venom factor: Bioassay for venom coagglutinin
31. Thrombotic thrombocytopenia with von Willebrand factor deficiency induced by botrocetin. An animal model
32. Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (terciopelo) snake venom
33. Pathological changes induced by BaH1, a hemorrhagic metalloproteinase isolated from Bothrops asper (terciopelo) snake venom, on mouse capillary blood vessels