Thyroid hormone analogues: Ready for prime time

Thyroid

Volumn 21, Issue 2, 2011, Pages 101-102

  Ladenson, Paul W ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BEXAROTENE; EPROTIROME; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MB 0734; MB 07344; MB 07811; PRODRUG; SOBETIROME; TETRAIODOTHYROACETIC ACID; THYROID HORMONE DERIVATIVE; THYROID HORMONE RECEPTOR; TIRATRICOL; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; BONE TURNOVER; DRUG BINDING; DRUG EFFICACY; DRUG INDUSTRY; DRUG MECHANISM; DRUG SAFETY; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; HYPOTHYROIDISM; NOTE; PRIORITY JOURNAL; THERMOGENESIS; THYROTOXICOSIS;

ATHEROSCLEROSIS; HUMANS; HYPERCHOLESTEROLEMIA; ISCHEMIA; NEOPLASMS; THYROID HORMONES; THYROTOXICOSIS; TRIIODOTHYRONINE;

EID: 79953251722     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2010.2100.com1     Document Type: Note

References (13)

1. Sherman SI, Ladenson PW 1992 Organ-specific effects of tiratricol: a thyroid hormone analog with hepatic, not pituitary, superagonist effects. J Clin Endocrinol Metab 75:901-905.
2. Goldman S, McCarren M, Morkin E, Ladenson PW, Edson R, Warren S, Ohm J, Thai H, Churby L, Barnhill J, O'Brien T, Anand I, Warner A, Dunlap M, Hattler B, Erikson J, Shih MC, Lavori P 2009 DITPA, a thyroid hormone analogue to treat heart failure: Phase II Trial VA Cooperative Study. Circulation 119:3093-3100.
3. Sherman SI, Gopal J, Haugen BR, Chiu AC, Whaley K, Nowlakha P, Duvic M 1999 Central hypothyroidism associated with retinoid X receptor-selective ligands. N Engl J Med 340:1075-1079. (Pubitemid 29162512)
4. Scanlan TS 2010 Sobetirome: a case history of bench-toclinic drug discovery and development. Heart Fail Rev 15: 177-182.
5. Berkenstam A, Kristensen J, Mellström K, Carlsson B, Malm J, Rehnmark S, Garg N, Andersson CM, Rudling M, Sjöberg F, Angelin B, Baxter JD 2008 The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci U S A 105:663-667.
6. Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang BH, Hou J, Boyer SH, van Poelje PD, Linemeyer DL 2007 Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A 104:15490-15495. (Pubitemid 47502944)
7. Ladenson PW, Kristensen JD, Ridgway EC, Olsson AG, Carlsson B, Klein I, Baxter JD, Angelin B 2010 Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med 362:906-916.
8. O'Gorman CS, Higgins MF, O'Neill MB 2009 Systematic review and metaanalysis of statins for heterozygous familial hypercholesterolemia in children: evaluation of cholesterol changes and side effects Pediatr Cardiol 30:482-489.
9. Davis PJ, Leonard JL, Davis FB 2008 Mechanisms of nongenomic actions of thyroid hormone. Front Neuroendocrinol 29:211-218. (Pubitemid 351467119)
10. Luidens MK, Mousa SA, Davis FB, Lin HY, Davis PJ 2010 Thyroid hormone and angiogenesis. Vascul Pharmacol 52:142-145.
11. Malm J, Färnega°rdhl M, Grover GJ, Koehler K, Ladenson PW 2009 Thyroid hormone antagonists: potential medical applications and structure activity relationships. Curr Med Chem 16:3258-3266.
12. Di Cosmo C, Liao XH, Dumitrescu AM, Weiss RE, Refetoff S 2009 A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport. Endocrinology 150:4450-4458.
13. Guran T, Turan S, Bircan R, Bereket A 2009 9 years followup of a patient with pituitary form of resistance to thyroid hormones (PRTH): comparison of two treatment periods of D-thyroxine and triiodothyroacetic acid (TRIAC). J Pediatr Endocrinol Metab 22:971-978.