Extracting molecular information from African natural products to facilitate unique African-led drug-discovery efforts

Future Medicinal Chemistry

Volumn 3, Issue 3, 2011, Pages 257-261

  Chibale, Kelly ^a   Guantai, Eric M ^a   Masimirembwa, Collen ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b African Institute of Biomedical Science and Technology   (Zimbabwe)

Author keywords

ADME guided medicinal chemistry; Africa; biotransformation; drug discovery; informatics; natural products

Indexed keywords

CYTOCHROME P450; NATURAL PRODUCT;

AFRICA; DRUG DEVELOPMENT; HEALTH CARE FINANCING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVIEW; TECHNIQUE;

AFRICA; BIOLOGICAL PRODUCTS; BIOTRANSFORMATION; COMMUNICABLE DISEASES; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; INFORMATION MANAGEMENT;

EID: 79953246499     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.10.299     Document Type: Review

References (12)

1. World Health Organization. WHO Traditional Medicine Strategy 2002-2005. Geneva, Switzerland (2002).
2. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 Years. J. Nat. Prod. 70, 461-477 (2007). An exhaustive review of natural products that have served as a source of new-drug entities and novel chemical structures in the 25 years prior to 2007. (Pubitemid 46595760)
3. Nyigo VA, Malebo HM. Drug discovery and developments in developing countries: Bottlenecks and way forward. Tanzania Health Res. Bull. 7, 154-158 (2005).
4. Trouiller P, Olliaro P, Torreele E, Orbinski J, Liang R, Ford N. Drug development for neglected diseases: A deficient market and a public-health policy failure. Lancet 359, 2188-2194 (2002). (Pubitemid 34694030)
5. Coon MJ. Cytochrome P450: Nature's most versatile biological catalyst. Annu. Rev. Pharmacol. Toxicol. 45, 1-25 (2005). (Pubitemid 40261796)
6. Fura A, Shu Y-Z, Zhu M, Hanson RL, Roongta V, Humphreys WG. Discovering drugs through biological transformation: Role of pharmacologically active metabolites in drug discovery. J. Med. Chem. 47(18), 4339-4350 (2004). An excellent account of biotransformation as a source of chemical diversity, and the importance of metabolites in drug discovery.
7. Claus BL, Underwood DJ. Discovery informatics: Its evolving role in drug discovery. Drug Discov. Today 7(18), 957-966 (2002). (Pubitemid 35286900)
8. Terstappen GC, Reggiani A. In silico research in drug discovery. Trends Pharmacol. Sci. 22(1), 23-26 (2001). (Pubitemid 32126282)
9. Bajorath J. Rational drug discovery revisited: Interfacing experimental programs with bio- and chemo-informatics. Drug Discov. Today 6(19), 989-995 (2001). (Pubitemid 32884420)
10. Moitessier N, Englebienne P, Lee D, Lawandi J, Corbeil CR. Towards the development of universal, fast and highly accurate docking/scoring methods: A long way to go. Br. J. Pharmacol. 153, S7-S26 (2008). (Pubitemid 351340987)
11. Eddershaw PJ, Beresford AP, Bayliss MK. ADME/PK as part of a rational approach to drug discovery. Drug Discov. Today 5(9), 409-414 (2000). (Pubitemid 30645737)
12. Yu H, Adedoyin A. ADME-Tox in drug discovery: Integration of experimental and computational technologies. Drug Discov. Today 8(18), 852-861 (2003). An overview of predictive (in silico and in vitro) ADME-toxicity, and its role in drug discovery. (Pubitemid 37083343)