Antibody-binding epitope differences in the nucleoprotein of avian and mammalian influenza a viruses

Viral Immunology

Volumn 24, Issue 2, 2011, Pages 101-107

  Varich, Natalia L ^a   Sadykova, Galina K ^a   Prilipov, Alexei G ^a   Kochergin Nikitsky, Konstantin S ^a   Kushch, Alla A ^a   Masalova, Olga V ^a   Klimova, Regina R ^a   Gitelman, Asya K ^a   Kaverin, Nikolai V ^a  

^a D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIBODY BINDING EPITOPE; EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2E6; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FOWL; HOST RANGE; INFLUENZA VIRUS A; INFLUENZA VIRUS A H10N7; INFLUENZA VIRUS A H11N6; INFLUENZA VIRUS A H13N6; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H4N6; INFLUENZA VIRUS A H5N1; INFLUENZA VIRUS A H5N2; INFLUENZA VIRUS A H7N1; MAMMAL; MOLECULAR RECOGNITION; NONHUMAN; PROKARYOTIC CELL; SITE DIRECTED MUTAGENESIS; STRAIN DIFFERENCE; VIRUS MUTANT; VIRUS STRAIN;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; DUCKS; EPITOPES; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA, HUMAN; MUTANT PROTEINS; PROTEIN BINDING; RNA-BINDING PROTEINS; VIRAL CORE PROTEINS;

AVES; HUMAN INFLUENZA VIRUS; INFLUENZA A VIRUS; MAMMALIA; ORTHOMYXOVIRIDAE; PROKARYOTA;

EID: 79953238967     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2010.0088     Document Type: Article

References (32)

1. Albo C, Valencia C, and Portela A: Identification of an RNA binding region within the N-terminal third of the influenza A virus nucleoprotein. J Virol 1995;69:3799-3806.
2. Biswas SK, Boutz PL, and Nayak DP: Influenza virus nu-cleoprotein interacts with influenza virus polymerase pro-teins. J Virol 1998;72:5493-5501. (Pubitemid 28283331)
3. Bodewes R, Kreijtz JH, Hillaire ML, Geelhoed-Mieras MM, Fouchier RA, Osterhaus AD, and Rimmelzwaan GF: Vacci-nation with whole inactivated virus vaccine affects the in-duction of heterosubtypic immunity against influenza virus A/H5N1 and immunodominance of virus-specific CD8+ T-cell responses in mice. J Gen Virol 2010;91:1743-1753.
4. Boon AC, de Mutsert G, Fouchier RA, Osterhaus AD, and Rimmelzwaan GF: The hypervariable immunodominant NP418-426 epitope from the influenza A virus nucleoprotein is recognized by cytotoxic T lymphocytes with high func-tional avidity. J Virol 2006;80:6024-6032. (Pubitemid 43849180)
5. Carragher DM, Kaminski DA, Moquin A, Hartson L, and Randall TD: A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus. J Immunol 2008;181:4168-4176.
6. Chen G-W, Chang S-C, Mok C-K, et al.: Genomic signatures of human versus avian influenza A viruses. Emerg Inf Dis 2006;12:1353-1360. (Pubitemid 44455211)
7. Finkelstein DB, Mukatira S, Mehta PK, Obenauer JC, Su X, Webster RG, and Naeve CW: Persistent host markers in pandemic and H5N1 influenza viruses. J Virol 2007;81: 10292-10299. (Pubitemid 47463304)
8. Fu T-M, Friedman A, Ulmer J B, Liu MA, and Donnelly JJ: Protective cellular immunity: cytotoxic T-lymphocyte re-sponses against dominant and recessive epitopes of influ-enza virus nucleoprotein induced by DNA immunization. J Virol 1997;71:2715-2721. (Pubitemid 27119908)
9. Gorman OT, Bean WJ, Kawaoka Y, Donatelli I, Guo Y, and Webster RG: Evolution of influenza A virus nucleoprotein genes: implications for the origin of H1N1 human and classical swine viruses. J Virol 1991;65:3704-3714
10. Herlocher ML, Bucher D, and Webster RG: Host range de-termination and functional mapping of the nucleoprotein and matrix genes of influenza viruses using monoclonal antibodies. Virus Res 1992;22:281-293.
11. Ilyushina NA, Khalenkov AM, Seiler JP, et al.: Adaptation of pandemic H1N1 influenza viruses in mice. J Virol 2010; 84:8607-8616.
12. Kim JH, Hatta M, Watanabe S, Neumann G, Watanabe T, and Kawaoka Y: Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza A viruses in mice. J Gen Virol 2010;91:1284-1289.
13. Kreijtz J H, de Mutsert G, van Baalen CA, Fouchier RAM, Osterhaus ADME, and Rimmelzwaan GF: Cross-recognition of avian H5N1 influenza virus by human cytotoxic T-lym-phocyte populations directed to human influenza A virus. J Virol 2008;82:5161-5166. (Pubitemid 351705225)
14. Kushch AA, Klimova RR, Masalova OV, et al.: Monoclonal antibodies to highly pathogenic avian influenza A(H5N1) strain isolated in the Russian Federation: development and properties. Vopr Virusol 2008;53:9-14.
15. Nakane PK, and Kawaoi A: Peroxidase-labeled antibody. A new method of conjugation. J Histochem Cytochem 1974;22: 1084-1091.
16. Ng AK-L, Zhang H, Tan K, et al.: Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization and vaccine design. FASEB J 2008;22:3638-3647
17. Philpott M, Easterday BC, and Hinshaw V: Neutralizing epitopes of the H5 hemagglutinin from a virulent avian in-fluenza virus and their relationships to pathogenicity. J Virol 1989;63:3453-3458. (Pubitemid 19181406)
18. Rimmelzwaan GF, Boon AC, Voeten JT, Berkhoff EG, Fouchier RA, and Osterhaus AD: Sequence variation in in-fluenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes. Virus Res 2004;103:97-100. (Pubitemid 38649067)
19. Rudneva IA, Kushch AA, Masalova OA, et al.: Antigenic epitopes in the hemagglutinin of Qinghai-type influenza H5N1 virus. Viral Immunol 2010;23:181-187
20. Shaw M, Cooper L, Xu X, et al.: Molecular changes as-sociated with the transmission of avian influenza A H5N1 and H9N2 viruses to humans. J Med Virol 2002;66: 107-114. (Pubitemid 34183725)
21. Tsfasman TM, Markushin SG, Akopova II, and Ghendon YZ: Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains. J Gen Virol 2007;88:2724-2729. (Pubitemid 47555026)
22. Turan K, Mibayashi M, Sugiyama K, Saito S, Numajiri A, and Nagata K: Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered virus genome. Nucleic Acid Res 2004;32: 643-652. (Pubitemid 38263055)
23. Van Wyke KL, Hinshaw VS, Bean WJ, and Webster RG: Antigenic variation of influenza A virus nucleoprotein de-tected with monoclonal antibodies. J Virol 1980;35:24-30. (Pubitemid 10080339)
24. Van Wyke KL, Bean WJ, and Webster RG: Monoclonal an-tibodies to the influenza A virus nucleoprotein affecting RNA transcription. J Virol 1981;39:313-317. (Pubitemid 11069838)
25. Varich NL, and Kaverin NV: Antigenically relevant amino acid positions as revealed in reactions of monoclonal anti-bodies with the nucleoproteins of closely related influenza A virus strains. Arch Virol 2004;149:2271-2276. (Pubitemid 39508965)
26. Varich NL, Kochergin-Nikitsky KS, Usachev EV, Usacheva OV, Prilipov AG, Webster RG, and Kaverin NV: Location of antigenic sites recognized by monoclonal antibodies in the influenza A virus nucleoprotein molecule. J Gen Virol 2009; 90:1730-1733.
27. Voeten JTM, Bestebroer TM, Nieuwkoop NJ, Fouchier RAM, Osterhaus ADME, and Rimmelzwaan GF: Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes. J Virol 2000;74: 6800-6807. (Pubitemid 30470663)
28. Yang M, Berhane Y, Salo T, Li M, Hole K, and Clavijo A: Development and application of monoclonal antibodies against avian influenza virus nucleoprotein. J Virol Meth 2008;147:265-274.
29. Ye Q, Krug RM, and Tao YJ: The mechanism by which in-fluenza A virus nucleoprotein forms oligomers and binds RNA. Nature 2006;444:1078-1082. (Pubitemid 46018528)
30. Yewdell JW: Monoclonal antibodies specific for discontinu-ous epitopes direct refolding of influenza A virus hemag-glutinin. Molec Immunol 2010;47:1132-1136.
31. Zhong W, Liu F, Dong L, Lu X, et al.: Significant impact of sequence variations in the nucleoprotein on CD8 T cell-me-diated cross-protection against influenza A virus infections. PloS One 2010;5:e10583.
32. Zimmermann P, Maenz B, Mayer D, Schwemmle M, and Kochs G: NP of PanH1N1 renders avian influenza A viruses insensitive to antiviral action of interferon-induced Mx proteins. XIV International Conference on Negative Strand Viruses, June 20-25, 2010, Brugge, Abstracts, 223.