Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1706-1712

  Sheng, Chunquan ^a   Che, Xiaoying ^a   Wang, Wenya ^a   Wang, Shengzheng ^a   Cao, Yongbing ^a   Yao, Jianzhong ^a   Miao, Zhenyuan ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Benzoheterocyclic derivatives antifungal activity; CYP51; Molecular docking; Non azole lead; Scaffold hopping

Indexed keywords

3 HEPTYL 6 METHYLQUINAZOLIN 4(3H) ONE; 3 HEXYL 6 METHYLQUINAZOLIN 4(3H) ONE; 3 OCTYL 6 METHYLQUINAZOLIN 4(3H) ONE; 8 BROMO 2 HEPTYL 5 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; 8 BROMO 2 HEXYL 5 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; 8 CHLORO 2 HEPTYL 5 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; 8 CHLORO 2 HEXYL 5 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; 8 CHLORO 5 METHYL 2 OCTYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; 8 FLUORO 2 HEPTYL 5 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; 8 FLUORO 2 HEXYL 5 METHYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; 8 FLUORO 5 METHYL 2 OCTYL 2,3,4,5 TETRAHYDRO 1H PYRIDO [4,3 B] INDOLE; ANTIFUNGAL AGENT; BENZIMIDAZOLE; BENZOHETEROCYCLIC DERIVATIVE; BENZOTHIAZOLE; BENZOXAZOLE DERIVATIVE; CARBOLINE DERIVATIVE; ETHYL 8 BROMO 3,4 DIHYDRO 1H PYRIDO [4,3 B] INDOLE 2(5H) CARBOXYLATE; ETHYL 8 BROMO 5 METHYL 3,4 DIHYDRO 1H PYRIDO [4,3 B] INDOLE 2(5H) CARBOXYLATE; N (BENZOOXAZOL 2 YLMETHYL) HEPTAN 1 AMINE; N (BENZOOXAZOL 2 YLMETHYL) HEXAN 1 AMINE; N (BENZOOXAZOL 2 YLMETHYL) OCTAN 1 AMINE; N (BENZOTHIAZOL 2 YLMETHYL) HEPTAN 1 AMINE; N (BENZOTHIAZOL 2 YLMETHYL) HEXAN 1 AMINE; N (BENZOTHIAZOL 2 YLMETHYL) OCTAN 1 AMINE; N [(1H BENZOIMIDAZOL 2 YL) METHYL] HEPTAN 1 AMINE; N [(1H BENZOIMIDAZOL 2 YL) METHYL] HEXAN 1 AMINE; N [(1H BENZOIMIDAZOL 2 YL) METHYL] OCTAN 1 AMINE; QUINAZOLIN 4 ONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; SCAFFOLD HOPPING; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; DRUG DESIGN; FUNGI; HETEROCYCLIC COMPOUNDS; HYDROGEN BONDING; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953217992     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.075     Document Type: Article

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