Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 7, 2011, Pages 2450-2457

  Aoyagi, Yutaka ^a   Adachi, Yoshiyuki ^a   Ozawa, Kei ^a   Yokomizo, Chihiro ^a   Gui, Ming Yu ^b   Jin, Yong Ri ^b   Li, Xu Wen ^b   Ohno, Naohito ^a   Takeya, Koichi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b JILIN UNIVERSITY   (China)

Author keywords

ent Kaurene; NF B; Rabdokunmin C; SAR; Semisynthesis

Indexed keywords

18 ACETYL 12 DEOXY 11,12 DEHYDRORABDOKUNMIN C; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN INHIBITOR; RABDOKUNMIN C DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION;

ANIMALS; DITERPENES; DITERPENES, KAURANE; HEP G2 CELLS; HUMANS; LEUKEMIA P388; MACROPHAGES; MICE; NF-KAPPA B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953214021     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.002     Document Type: Article

References (14)

1. L.A.J. O'Neill Nat. Rev. Drug Disc. 5 2006 549
2. E. Kopp, and S. Ghosh Science 265 1994 956
3. P. Bremner, and M. Heinrich J. Pharm. Pharmacol. 54 2002 453
4. A. Navarro, B. De las Heras, and A.M. Villar del Fresno Z. Naturforsch., C: Biosci. 52 1997 844
5. A. Castrillo, B. De las Heras, S. Hortelano, B. Rodriguez, A. Villar, and L. Bosca J. Biol. Chem. 276 2001 15854
6. B.Y. Hwang, J.H. Lee, T.H. Koo, H.S. Kim, Y.S. Hong, J.S. Ro, K.S. Lee, and J.J. Lee Planta Med. 67 2001 406
7. P.M. Giang, H.Z. Jin, P.T. Son, J.H. Lee, Y.S. Hong, and J.J. Lee J. Nat. Prod. 66 2003 1217
8. S.-X. Huang, Q.-S. Zhao, G. Xu, W.-L. Xiao, R.-T. Li, A.-J. Hou, S.-L. Peng, L.-S. Ding, and H.-D. Sun J. Nat. Prod. 68 2005 1758
9. M.Y. Gui, Y. Aoyagi, Y.R. Jin, X.W. Li, T. Hasuda, and K. Takeya J. Nat. Prod. 67 2004 373
10. Y. Aoyagi, Y. Nishioka, F. Tobe, T. Hasuda, K. Takeya, M.Y. Gui, Y.R. Jin, and X.W. Li Bioorg. Med. Chem. 14 2006 5802
11. M. Xu, P. Cheng, B. Xiong, Z. Wang, Y. Guo, and G. Xu Zhiwu Xuebao 34 1992 950
12. H. Zhang, and H. Sun Phytochemistry 28 1989 3405
13. N.-H. Nam Mini-Rev. Med. Chem. 6 2006 945
14. T. Ikezoe, Y. Yang, K. Bandobashi, T. Saito, S. Takemoto, H. Machida, K. Togitani, H.P. Koeffler, and H. Taguchi Mol. Cancer Ther. 4 2005 578