Comparison of combinatory effects of PCBs (118, 138, 153 and 180) with 17 β-estradiol on proliferation and apoptosis in MCF-7 breast cancer cells

Toxicology and Industrial Health

Volumn 27, Issue 4, 2011, Pages 315-321

  Ptak, Anna ^a   Mazur, Karolina ^a   Gregoraszczuk, Ewa L ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

17 estradiol; apoptosis; combinatory effects; PCB; proliferation

Indexed keywords

BROXURIDINE; CASPASE 9; ESTRADIOL; PHENOLSULFONPHTHALEIN; POLYCHLORINATED BIPHENYL DERIVATIVE;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVITY; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL;

APOPTOSIS; BREAST NEOPLASMS; BROMODEOXYURIDINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ESTRADIOL; FEMALE; HUMANS; POLYCHLORINATED BIPHENYLS;

BOVINAE;

EID: 79953213209     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233710387003     Document Type: Article

References (21)

1. Bonefeld-Jørgensen EC, Andersen HR, Rasmussen TH, and Vinggaard AM (2001) Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology, 158: 141-153.
2. Burow ME, Tang Y., Collins-Burow BM, et al. (1999) Effects of environmental estrogens on tumor necrosis factor alpha-mediated apoptosis in MCF-7 cells. Carcinogenesis, 20: 2057-2061.
3. Glauert HP, Tharappel JC, Banerjee S., et al. (2008) Inhibition of the promotion of hepatocarcinogenesis by 2,2’,4,4’,5,5’-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicology and Applied Pharmacology, 232: 302-238.
4. Gregoraszczuk EL, Rak A., Ludewig G., and Gasinska A. (2008) Effect of estradiol, PCB3 and their hydroxylated metabolites on proliferation, cell cycle and apoptosis of human breast cancer cells. Environmental Toxicology and Pharmacology, 25: 227-233.
5. Kandouz M., Siromachkova M., Jacob D., Chretien Marquet B., Therwath A., and Gompel A. (1996) Antagonism between estradiol and progestin on Bcl-2 expression in breast-cancer cells. International Journal of Cancer, 68: 120-125.
6. Köller S., Seliger E., Kaltwaer P., and Röpke F. (2004) Studies on the influence of ecologically relevant substances on primary cell cultures of the human endometrium. Journal of Fertility and Reproduction, 14: 7-12.
7. Lin CH, Huang CL, Chuang MC, et al. (2009) Protective role of estrogen receptor-alpha on lower chlorinated PCB congener-induced DNA damage and repair in human tumoral breast cells. Toxicology Letters, 188: 11-19.
8. Lin CH, Lin PH (2006) Induction of ROS formation, poly (ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells. Chemical and Biological Interactions, 162: 181-194.
9. Lippert TH, Seeger H., and Mueck AO (2000) The impact of endogenous estradiol metabolites on carcinogenesis. Steroids, 65: 357-369.
10. Lu Z., Lee EY, Robertson LW, Glauert HP, and Spear BT (2004) Effect of 2,2’,4,4’,5,5’-hexachlorobiphenyl (PCB-153) on hepatocyte proliferation and apoptosis in mice deficient in the p50 subunit of the transcription factor NF-kappaB. Toxicological Sciences, 81(1): 35-42.
11. Mobley JA, Brueggemeier RW (2004) Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer. Carcinogenesis, 25: 3-9.
12. Ptak A., Ludewig G., Rak A., Nadolna W., Bochenek M., and Gregoraszczuk EL (2009) Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis. Environment International Jul 13. In press.
13. Radice S., Chiesara E., Fucile S., and Marabini L. (2008) Different effects of PCB101, PCB118, PCB138 and PCB153 alone or mixed in MCF-7 breast cancer cells. Food and Chemical Toxicology, 46: 2561-2567.
14. Rajapakse N., Ong D., and Kortenkamp A. (2001) Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens. Toxicological Sciences, 60: 296-304.
15. Rajapakse N., Silva E., Kortenkamp A. (2002) Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action. Environmental Health Perspectives, 110: 917-921.
16. Schmidt S., Michna H., and Diel P. (2005) Combinatory effects of phytoestrogens and 17beta-estradiol on proliferation and apoptosis in MCF-7 breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology, 94: 445-449.
17. Seeger H., Wallwiener D., Kraemer E., and Mueck AO (2006) Comparison of possible carcinogenic estradiol metabolites: effects on proliferation, apoptosis and metastasis of human breast cancer cells. Maturitas, 54: 72-77.
18. Silva E., Rajapakse N., and Kortenkamp A. (2002) Something from “nothing”-eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environmental Science and Technology, 36: 1751-1756.
19. Tharappel JC, Lee EY, Robertson LW, Spear BT, and Glauert HP (2002) Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls. Toxicology and Applied Pharmacology, 179: 172-184.
20. Villalobos M., Olea N., Brotons JA, Olea-Serrano MF, Ruiz de Almodovar JM, and Pedraza V. (1995) The E-screen assay: a comparison of different MCF7 cell stocks. Environmental Health Perspectives, 103: 844-850.
21. Wang C., Kurzer MS (1998) Effects of phytoestrogens on DNA synthesis in MCF-7 cells in the presence of estradiol or growth factors. Nutrition Cancer, 31: 90-100.