Tranexamic acid in elective craniosynostosis surgery: It works, but how?

Anesthesiology

Volumn 114, Issue 4, 2011, Pages 737-738

  Holcomb, John B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; HETASTARCH; TRANEXAMIC ACID;

BLEEDING; BOLUS INJECTION; CRANIOFACIAL SYNOSTOSIS; CRYSTALLOID; EDITORIAL; ELECTIVE SURGERY; ERYTHROCYTE TRANSFUSION; FIBRINOLYSIS; HEMOSTASIS; HUMAN; OPTIMAL DRUG DOSE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESUSCITATION; THROMBOELASTOGRAPHY;

EID: 79953208097     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3182110083     Document Type: Editorial

References (7)

1. Dadure C, Sauter M, Bringuier S, Bigorre M, Raux O, Rochette A, Canaud N, Capdevila X: Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: A randomized, double-blind study. ANESTHESIOLOGY 2011; 114:856-61
2. Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF: Efficacy of tranexamic acid in pediatric craniosynostosis surgery: A double-blind, placebocontrolled trial. ANESTHESIOLOGY 2011; 114:862-71
3. Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, Bochicchio G, Bulger E, Cotton BA, Davis D, Dutton R, Hauser CJ, Hess JR, Hides GA, Knudson P, Mackenzie E, McGinnis RL, Michalek J, Moore FA, Omert L, Pollock BH, Tortella B, Sugarman J, Schreiber MA, Wade CE. Challenges to effective research in acute trauma resuscitation: Consent and endpoints. Shock 2011; 35:107-13
4. Bolliger D, Szlam F, Levy JH, Molinaro RJ, Tanaka KA: Haemodilution-induced profibrinolytic state is mitigated by freshfrozen plasma: Implications for early haemostatic intervention in massive haemorrhage. Br J Anaesth 2010; 104:318-25
5. Holcomb JB: Traditional transfusion practices are changing. Crit Care 2010; 14:162
6. CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 2010; 376:23-32
7. Martin K, Breuer T, Gertler R, Hapfelmeier A, Schreiber C, Lange R, Hess J, Wiesner G. Tranexamic acid versus-aminocaproic acid: Efficacy and safety in paediatric cardiac surgery. Eur J Cardiothorac Surg 2010 [Epub ahead of print]