Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: Fermentation, isolation and biological activity

Journal of Antibiotics

Volumn 52, Issue 1, 1999, Pages 13-19

  Komaki, Hisayuki ^a,b   Nemoto, Akira ^a   Tanaka, Yasushi ^a   Takagi, Hiroaki ^a   Yazawa, Katsukiyo ^b   Mikami, Yuzuru ^b   Shigemori, Hideyuki ^c   Kobayashi, Jun'ichi ^c   Ando, Akikazu ^b   Nagata, Yoshiho ^b  

^a Higeta Shoyu Co Ltd   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYCLOSPORIN A; DITERPENOID; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL TISSUE; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG ISOLATION; FEMALE; FERMENTATION; HUMAN; HUMAN CELL; MOUSE; NOCARDIA BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL;

NOCARDIA BRASILIENSIS;

EID: 0032931915     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.52.13     Document Type: Article

References (25)

1. NEMOTO, A.; Y. TANAKA, Y. KARASAKI, H. KOMAKI, K. YAZAWA, Y. MIKAMI, T. TOJO, K. KADOWAKI, M. TSUDA & J. KOBAYASHI: Brasiliquinones A, B and C, new benz[a]anthraquinone antibiotics from Nocardia brasiliensis. I. Producing strain, isolation and biological activities of the antibiotics. J. Antibiotics 50: 18-21, 1997
2. TSUDA, M.; H. SATO, Y. TANAKA, K. YAZAWA, Y. MIKAMI, T. SASAKI & J. KOBAYASHI: Brasiliquinones A-C, new cytotoxic benz[a]anthraquinone with an ethyl group at C-3 from actinomycete Nocardia brasiliensis. J. Chem. Soc., Perkins Trans. 1: 1773-1775, 1996
3. KOBAYASHI, J.; M. TSUDA, A. NEMOTO, Y. TANAKA, K. YAZAWA & Y. MIKAMI: Brasilidine A, a new cytotoxic isonitrile-containing indole alkaloid from the actinomycete Nocardia brasiliensis. J. Nat. Prod. 60: 719-720, 1997
4. TANAKA, Y.; U. GRÄFE, K. YAZAWA, Y. MIKAMI & M. RITZAU: Nocardicyclins A and B: New anthracycline antibiotics produced by Nocardia pseudobrasiliensis. J. Antibiotics 50: 822-827, 1997
5. TANAKA, Y.; H. KOMAKI, K. YAZAWA, Y. MIKAMI, A. NEMOTO, T. TOJYO, K. KADOWAKI, H. SHIGEMORI & J. KOBAYASHI: Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: Producing strain, isolation and biological activity. J. Antibiotics 50: 1036-1041, 1997
6. SHIGEMORI, H.; Y. TANAKA, K. YAZAWA, Y. MIKAMI & J. KOBAYASHI: Brasilinolide A, new immunosuppressive macrolide from actinomycete Nocardia brasiliensis. Tetrahedron 52: 9031-9034, 1996
7. HANSEN, M. B.; S. E. NIELSEN & B. BERG: Reexamination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Method 119: 203-210, 1989
8. HATANAKA, H.; T. KINO, S. MIYATA, N. INAMURA, A. KURODA, T. GOTO, H. TANAKA & M. OKUHARA: FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J. Antibiotics 41: 1592-1601, 1988
9. HARRISON, P. K. & R. L. STEIN: Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: Evidence for the existence of a family of distinct enzymes. Biochemistry 29: 3813-3816, 1990
10. TAKAHASHI, N.; T. HAYANO & M. SUZUKI: Peptidyl-prolyl cis-trans isomerase is the cyclosporinA-binding protein cyclophilin. Nature 337: 476-478, 1989
11. National Committee for Clinical Laboratory Standards: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically - Second Edition. Tentative Standard, National Committee for Clinical Laboratory Standards, Villanova, Pa. 1998
12. National Committee for Clinical Laboratory Standards: Reference method for broth dilution antifungal susceptibility testing of yeast. Approved standard M27-A. National Committee for Clinical Laboratory Standards, Villanova, Pa. 1997
13. SHIGEMORI, H.; H. KOMAKI, K. YAZAWA, Y. MIKAMI, A. NEMOTO, Y. TANAKA, T. SASAKI, Y. IN, T. ISHIDA & J. KOBAYASHI: Brasilicardin A, a novel tricyclic metabolite with potent immunosuppressive activity from actinomycete Nocardia brasiliensis. J. Org. Chem. 63: 6900-6904, 1998
14. TUNER, W. B. & D. C. ALDRIDGE: Fungal Metabolites. II. Academic Press, London, 1983
15. HAYRY, P.; L. C. ANDERSSON, S. NORDLING & M. VIROLAINEN: Allograft response in vitro. Transplant. Rev. 12: 91-140, 1972
16. BOREL, J. F.: History of cyclosporin A and its significance in immunology. In Cyclosporin A. Ed. J. F. BOREL, pp. 5-17. Elsevier Biochemical Press, Amsterdam, 1982
17. WHITE, D. J. G. : Cyclosporin A: Clinical pharmacology and therapeutic potential. Drugs 24: 322-334, 1982
18. OKUHARA, M.; T. GOTO, T. KINO & J. HOSODA: Discovery and development of a immunosuppressant, tacrolimus (FK 506). Nippon Nogeikagaku Kaishi 70: 1-8, 1996
19. JOHANSSON, A. & E. MOLLER: Evidence that the immunosuppressive effects of FK506 and cyclosporin are identical. Transplantation 50: 1001-1007, 1990
20. LIN, C. S.; R. C. BOLTZ, J. J. SIEKIERKA & N. H. SIGAL: FK506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes. Cell Immunol. 133: 269-284, 1991
21. KINO, T.; H. HATANAKA, S. MIYATA, N. INAMURA, M. NISHIYAMA, T. YAJIMA, T. GOTO, M. OKUHARA, M. KOHSAKA, H. AOKI & T. OCHIAI: FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. J. Antibiotics 40: 1256-1265, 1987
22. LIU, J.; J. D. FARMER Jr, W. S. LANE, J. FRIEDMAN, I. WEISSMAN & S. L. SCHREIBER: Calcincurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815, 1991
23. BOREL, J. F.; C. FEURER, C. MAGNEE & H. STAHELIN: Effect of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology 32: 1017-1025, 1997
24. KLINTMALM, G. B. & T. A. GONMA: Nephrotoxicity associated with cyclosporine and FK506. Liver Transpl. Surg. 1 (5 Suppl. 1): 11-19, 1995
25. BENNETT, W. M.; E. A. BURDMANN, T. F. ANDOH, D. C. HOUGHTON, J. LINDSLEY & L. W. ELZINGA: Nephrotoxicity of immunosuppressive drugs. Nephrol. Dial. Transplant. 9 (Suppl. 4): 141-145, 1994