Retinol binding protein-4 as a serum biomarker of intrahepatic lipid content in obese children - preliminary report

Acta Biochimica Polonica

Volumn 58, Issue 1, 2011, Pages 35-38

  Romanowska, Anna ^a   Lebensztejn, Dariusz M ^a   Skiba, Elzbieta ^a   Tarasów, Eugeniusz ^a   Kaczmarski, Maciej ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Adipokines; Biomarker; Children; NAFLD; Obesity; RBP 4

Indexed keywords

LIPID; PLASMA RETINOL BINDING PROTEIN; RBP4 PROTEIN, HUMAN;

ADOLESCENT; ARTICLE; BLOOD; CHILD; FATTY LIVER; FEMALE; HUMAN; MALE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY;

ADOLESCENT; CHILD; FATTY LIVER; FEMALE; HUMANS; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; OBESITY; RETINOL-BINDING PROTEINS, PLASMA;

ANIMALIA;

EID: 79953179384     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Alkhouri N, Lopez R, Berk M, Feldstein AE (2009) Serum retinolbinding protein 4 levels in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol 43: 985-989.
2. Angulo P (2002) Nonalcoholic fatty liver disease. N Eng J Med 346: 1221-1231.
3. Argo CK, Caldwell SH (2009) Epidemiology and natural history of non-alcoholic steatohepatitis. Clin Liver Dis 13: 511-531.
4. Cengiz C, Ardicoglu Y, Bulut S, Boyacioglu S (2009) Serum retinolbinding protein 4 in patients with nonalcoholic fatty liver disease: does it have a significant impact on pathogenesis? Eur J Gastroenterol Hepatol 22: 813-819.
5. Graham TE, Wason CJ, Blüher M, Kahn BB (2007) Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia 50: 814-823.
6. Joy D, Thava VR, Scott BB (2003) Diagnosis of fatty liver disease: is biopsy necessary? Eur J Gastroenterol Hepatol 15: 539-543.
7. Kershaw EF, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556.
8. Lebensztejn DM, Wojtkowska M, Skiba E, Werpachowska I, Tobolczyk J, Kaczmarski M (2009) Serum concentration of adiponectin, leptin and resistin in obese children with non-alcoholic fatty liver disease. Adv Med Sci 54: 177-182.
9. Loomba R, Sirlin CB, Lavine JE (2009) Advances in pediatric nonalcoholic fatty liver disease. Hepatology 50: 1282-1293.
10. Louthan MV, Barve S, McClain CJ, Joshi-Barve S (2005) Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. J Pediatr 147: 835-838.
11. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28: 412-419.
12. Milner K-L, van der Poorten D, Bugianesi E, Kench JG, Lam KSL, Chisholm DJ et al (2009) Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease. Hepatology 49: 1936-1934.
13. Nobili V, Alkhouri N, Alisi A, Ottino S, Lopez R, Manco M et al (2009) Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 7: 575-579.
14. Patton HM, Sirling C, Behling C, Middleton M, Schwimmer JB, Lavine JE (2006) Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications of future research. J Pediatr Gastroenterol Nutr 43: 413-427.
15. Perseghin G, Lattuada G, De Cobelli F, Esposito A, Belloni E, Canu T (2007) Serum retinol-binding protein-4, leptin, and adiponectin concentrations are related to ectopic fat accumulation. J Clin Endocrinol Metab 92: 4883-4888.
16. Ratziu V, Charlotte F, Heurtier A, Gombert S, Giral P, Bruckert E (2005) Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 128: 1898-1906.
17. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M (2002) The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 123: 745-750.
18. Saverymuttu SH, Joseph AE, Maxwell JD (1986) Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed) 292: 13-15.
19. Schina M, Koskinas J, Tiniakos D, Hadziyannis E, Savvas S, Karamanos B, Manesis E, Archimandritis A (2009) Circulating and liver tissue levels of retinol-binding protein-4 in non-alcoholic fatty liver disease. Hepatol Res 39: 972-978.
20. Seo JA, Kim NH, Park SY, Kim HY, Ryu OH, Lee KW et al. (2008) Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease. Clin Endocrinol 68: 555-560.
21. Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E et al (2007) High circulation retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care 30: 1173-1178.
22. Tarasów E, Siergiejczyk L, Panasiuk A, Kubas B, Dzienis W, Prokopowicz D, Walecki J (2002) MR proton spectroscopy in liver examinations of healthy individuals in vivo. Med Sci Monit 8: 36-40.
23. Vida S (1993) A computer program for non-parametric receiver operating characteristics analysis. Comput Methods Programs Biome 40: 95-101.
24. Wu H, Jia W, Bao Y, Lu J, Zhu J, Wang R et al. (2008) Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 79: 185-190.
25. Yagmur E, Weiskirchen R, Gressner AM, Trautwein C, Tacke F (2007) Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4. Diabetes Care 30: 1168-1172.
26. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436: 356-362.