Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 5, 2011, Pages 821-828

  Chen, Y X ^a,b   Allars, M ^b   Maiti, K ^b   Angeli, G L ^b   Abou Seif, C ^b   Smith, R ^b   Nicholson, R C ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c JOHN HUNTER HOSPITAL   (Australia)

Author keywords

Apoptosis; BeWo; cAMP; Choriocarcinoma; Differentiation; Placenta; Serum; Viability

Indexed keywords

8 BROMO CYCLIC AMP; CASPASE 3; CHARCOAL; CHORIONIC GONADOTROPIN BETA SUBUNIT; FAS ANTIGEN; FAS LIGAND; PROTEIN; SYNCYTIN 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DIFFERENTIATION; CELL FUSION; CELL NUCLEUS; CELL STIMULATION; CELL SURVIVAL; CELL VIABILITY; CHORIOCARCINOMA; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTROPHOBLAST; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; FETAL CALF SERUM; HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PROTEIN EXPRESSION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANTIGENS, CD95; APOPTOSIS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL FUSION; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, SERUM-FREE; FAS LIGAND PROTEIN; FORSKOLIN; GENE EXPRESSION REGULATION; GIANT CELLS; HUMANS; TROPHOBLASTS;

EID: 79953166742     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.02.007     Document Type: Article

References (30)

1. S. Al-Nasiry, B. Spitz, M. Hanssens, C. Luyten, and R. Pijnenborg Differential effects of inducers of syncytialisation and apoptosis on BeWo and JEG-3 choriocarcinoma cells Hum Reprod 21 2006 193 201 (Pubitemid 41794311)
2. S. Black, M. Kadyrov, P. Kaufmann, B. Ugele, N. Emans, and B. Huppertz Syncytial fusion of human trophoblast depends on caspase 8 Cell Death Differ 11 2004 90 98 (Pubitemid 38111376)
3. G.J. Burton, J.N. Skepper, J. Hempstock, T. Cindrova, C.J. Jones, and E. Jauniaux A reappraisal of the contrasting morphological appearances of villous cytotrophoblast cells during early human pregnancy; evidence for both apoptosis and primary necrosis Placenta 24 2003 297 305 (Pubitemid 37184747)
4. J. Chen, X.S. Su, Y.F. Jiang, G.Z. Gong, Y.H. Zheng, and G.Y. Li Transfection of apoptosis related gene Fas ligand in human hepatocellular carcinoma cells and its significance in apoptosis World J Gastroenterol 11 2005 2653 2655 (Pubitemid 40704286)
5. M.V. Clement, and I. Stamenkovic Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions J Exp Med 180 1994 557 567 (Pubitemid 24224132)
6. J.L. Frendo, D. Olivier, V. Cheynet, J.L. Blond, O. Bouton, and M. Vidaud Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation Mol Cell Biol 23 2003 3566 3574 (Pubitemid 36539189)
7. M. Gauster, and B. Huppertz The paradox of caspase 8 in human villous trophoblast fusion Placenta 31 2010 82 88
8. S. Guller, and L. LaChapelle The role of placental Fas ligand in maintaining immune privilege at maternal-fetal interfaces Semin Reprod Endocrinol 17 1999 39 44 (Pubitemid 29293551)
9. A. Hammer, A. Blaschitz, C. Daxbock, W. Walcher, and G. Dohr Fas and Fas-ligand are expressed in the uteroplacental unit of first-trimester pregnancy Am J Reprod Immunol 41 1999 41 51 (Pubitemid 29108230)
10. A. Hammer, M. Hartmann, P. Sedlmayr, W. Walcher, G. Kohnen, and G. Dohr Expression of functional Fas ligand in choriocarcinoma Am J Reprod Immunol 48 2002 226 234
11. S. Handwerger New insights into the regulation of human cytotrophoblast cell differentiation Mol Cell Endocrinol 323 2010 94 104
12. B. Huppertz, H.G. Frank, F. Reister, J. Kingdom, H. Korr, and P. Kaufmann Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro Lab Invest 79 1999 1687 1702 (Pubitemid 30013932)
13. P. Kaufmann, S. Black, and B. Huppertz Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia Biol Reprod 69 2009 1 7
14. S.W. Kauma, T.F. Huff, N. Hayes, and A. Nilkaeo Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus J Clin Endocrinol Metab 84 1999 2188 2194 (Pubitemid 30647053)
15. L.C. Kao, S. Caltabiano, S. Wu, J.F. Strauss 3rd, and H.J. Kliman The human villous cytotrophoblast: interactions with extracellular matrix proteins, endocrine function, and cytoplasmic differentiation in the absence of syncytium formation Dev Biol 130 1988 693 702 (Pubitemid 19016100)
16. R. Kim, M. Emi, K. Tanabe, Y. Uchida, and T. Toge The role of Fas ligand and transforming growth factor beta in tumor progression: molecular mechanisms of immune privilege via Fas-mediated apoptosis and potential targets for cancer therapy Cancer 100 2004 2281 2291 (Pubitemid 38657874)
17. H.J. Kliman, J.E. Nestler, E. Sermasi, J.M. Sanger, and J.F. Strauss 3rd Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae Endocrinology 118 1986 1567 1582 (Pubitemid 16078536)
18. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
19. A. Malassine, and L. Cronier Hormones and human trophoblast differentiation: a review Endocrine 19 2002 3 11 (Pubitemid 36106248)
20. T.M. Mayhew, L. Leach, R. McGee, W.W. Ismail, R. Myklebust, and M.J. Lammiman Proliferation, differentiation and apoptosis in villous trophoblast at 13-41 weeks of gestation (including observations on annulate lamellae and nuclear pore complexes) Placenta 20 1999 407 422 (Pubitemid 29301614)
21. T.M. Mayhew Villous trophoblast of human placenta: a coherent view of its turnover, repair and contributions to villous development and maturation Histol Histopathol 16 2001 1213 1224 (Pubitemid 32994465)
22. S. Mi, X. Lee, X. Li, G.M. Veldman, H. Finnerty, and L. Racie Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis Nature 403 2000 785 789 (Pubitemid 30111841)
23. G. Mor, L.S. Gutierrez, M. Eliza, F. Kahyaoglu, and A. Arici Fas-fas ligand system-induced apoptosis in human placenta and gestational trophoblastic disease Am J Reprod Immunol 40 1998 89 94 (Pubitemid 28380063)
24. D.W. Morrish, V. Manickavel, L.D. Jewell, and O. Siy Immunolocalization of alpha and beta chains of human chorionic gonadotropin, placental lactogen and pregnancy-specific beta-glycoprotein in term placenta by a touch preparation method Histochemistry 88 1987 57 60 (Pubitemid 18012387)
25. S.G. Payne, S.C. Smith, S.T. Davidge, P.N. Baker, and L.J. Guilbert Death receptor Fas/Apo-1/CD95 expressed by human placental cytotrophoblasts does not mediate apoptosis Biol Reprod 60 1999 1144 1150 (Pubitemid 29196766)
26. G. Rajashekhar, A. Loganath, A.C. Roy, and J.M. Mongelli Co-expression of Fas (APO-1, CD95)/Fas ligand by BeWo and NJG choriocarcinoma cell lines Gynecol Oncol 91 2003 101 111 (Pubitemid 37188599)
27. G. Rajashekhar, A. Loganath, A.C. Roy, and J.M. Mongelli Resistance to Fas-mediated cell death in BeWo and NJG choriocarcinoma cell lines: implications in immune privilege Gynecol Oncol 91 2003 89 100 (Pubitemid 37188598)
28. S.C. Smith, P.N. Baker, and E.M. Symonds Placental apoptosis in normal human pregnancy Am J Obstet Gynecol 177 1997 57 65 (Pubitemid 27327311)
29. S.L. Straszewski-Chavez, V.M. Abrahams, and G. Mor The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy Endocr Rev 26 2005 877 897 (Pubitemid 41770156)
30. L. White, A. Dharmarajan, and A. Charles Caspase-14: a new player in cytotrophoblast differentiation Reprod Biomed Online 14 2007 300 307 (Pubitemid 46463627)