Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3′-C-methyl- ribonucleosides as antitumor agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1499-1504

  Cappellacci, Loredana ^a   Petrelli, Riccardo ^a   Franchetti, Palmarisa ^a   Vita, Patrizia ^a   Kusumanchi, Praveen ^b   Kumar, Mohineesh ^b   Jayaram, Hiremagalur N ^b,c   Zhou, Bingsen ^d   Yen, Yun ^d   Grifantini, Mario ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b RICHARD L ROUDEBUSH VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

3 C Methyladenosine; Antitumor activity; Purine ribonucleosides; Ribonucleotide reductase inhibitors

Indexed keywords

2 AMINO N 6 HYDROXY 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; 2 AMINO N 6 METHOXY N 6 METHYL 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; 2 AMINO N6 AMINO 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; 2 AMINO N6 METHOXY 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; 2 CHLORO N6 AMINO ADENOSINE; 2 HYDRAZINO N6 AMINO ADENOSINE; 3' C METHYLRIBONUCLEOSIDE DERIVATIVE; ANTINEOPLASTIC AGENT; HYDRAZINO 9 BETA DEXTRO RIBOFURANOSYLPURINE; N 6 AMINO 2' DEOXYADENOSINE; N 6 AMINO 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; N 6 AMINOPURINE 9 BETA DEXTRO RIBONUCLEOSIDE DERIVATIVE; N 6 HYDROXY 2' DEOXYADENOSINE; N 6 HYDROXY 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; N 6 METHOXY 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; N 6 METHOXY N 6 METHYL 9H (3 C METHYL BETA DEXTRO RIBOFURANOSYL)ADENINE; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; METHYLATION; SUBSTITUTION REACTION;

ADENINE; ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; RIBONUCLEOSIDES; RIBONUCLEOTIDE REDUCTASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 79953165649     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.055     Document Type: Article

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