Gender-specific association of serum uric acid with metabolic syndrome and its components in juvenile obesity

Clinical Chemistry and Laboratory Medicine

Volumn 49, Issue 1, 2011, Pages 129-136

  Krzystek Korpacka, Malgorzata ^a   Patryn, Eliza ^a   Kustrzeba Wojcicka, Irena ^a   Chrzanowska, Joanna ^a   Gamian, Andrzej ^a,b   Noczynska, Anna ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b WROCLAW RESEARCH CENTRE EIT   (Poland)

Author keywords

Adolescents; Children; Insulin resistance; Metabolic syndrome; Obesity; Uric acid

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

ABDOMINAL OBESITY; ADOLESCENT; ARTICLE; BLOOD PRESSURE; BODY HEIGHT; BODY MASS; CHILD; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SEX DETERMINATION; SEXUAL DEVELOPMENT; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; OBESITY; POLAND; RISK FACTORS; SEX FACTORS; URIC ACID;

EID: 79953146998     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.011     Document Type: Article

References (44)

1. Heinig M, Johnson RJ. Role of uric acid in hypertension, renal disease and metabolic syndrome. Cleve Clin J Med 2006;73:1059-64. (Pubitemid 44883981)
2. Kanellis J, Kang D-H. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol 2005;25:39-42. (Pubitemid 40128147)
3. Alper AB Jr, Chen W, Yau L, Srinivasan SR, Berenson GS, Hamm LL. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension 2005;45:34-8. (Pubitemid 40066410)
4. Sánchez-Lozada LG, Nakagawa T, Kang DH, Feig DI, Franco M, Johnson RJ, et al. Hormonal and cytokine effects of uric acid. Curr Opin Nephrol Hypertens 2006;15:30-3.
5. Feig DI, Mazzali M, Kang D-H, Nakagawa T, Price K, Kannelis J, et al. Serum uric acid: a risk factor and a target for treatment? J Am Soc Nephrol 2006;17:S69-73.
6. Invitti C, Maffeis C, Gilardini L, Pontiggia B, Mazzilli G, Girola A, et al. Metabolic syndrome in obese Caucasian children: prevalence using WHO-derived criteria and association with non-traditional cardiovascular risk factors. Int J Obes (Lond) 2006;30:627-33.
7. Kodama S, Saito K, Yachi Y, Asumi M, Sugawara A, Totsuka K, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care 2009;32:1737-42.
8. Hovind P, Rossing P, Tarnow L, Johnson RJ, Parving HH. Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study. Diabetes 2009;58:1668-71.
9. Ford ES, Li C, Cook S, Choi HK. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 2007;115:2526-32. (Pubitemid 46763226)
10. Denzer C, Muche R, Mayer H, Heinze E, Debatin KM, Wabitsch M. Serum uric acid levels in obese children and adolescents: linkage to testosterone levels and pre-metabolic syndrome. J Pediatr Endocrinol Metab 2003;16:1225-32. (Pubitemid 38016427)
11. Pacifico L, Cantisani V, Anania C, Bonaiuto E, Martino F, Pascone R, et al. Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children. Eur J Endocrinol 2009;160:45-52.
12. Ferguson TF, Funkhouser E, Roseman J. Factor analysis of metabolic syndrome components in the Coronary Artery Risk Development in Young Adults (CARDIA) study: examination of factors by race-sex groups and across time. Ann Epidemiol 2010;20:194-200.
13. Croymans DM, Sanchez A, Barth JD, Roberts CK. Carotid intima-media thickness, dietary intake, and cardiovascular phenotypes in adolescents: relation to metabolic syndrome. Metabolism 2010;59:533-9.
14. IASO. International Obesity TaskForce: EU Platform on diet, physical activity and health briefing paper. Brussels, 2005.
15. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. Br Med J 2000;320:1240-3. (Pubitemid 30240471)
16. Palczewska I, Niedzwiecka Z. Wskazniki rozwoju somatycznego dzieci i mlodziezy warszawskiej. (Indices of somatic development of children and adolescents in Warsaw). Med Wieku Rozw 2002;2(Suppl 1).
17. Cole TJ, Faith MS, Pietrobelli A, Heo M. What is the best measure of adiposity change in growing children: BMI, BMI%, BMI z-score or BMI centile? Eur J Clin Nutr 2005;59:419-25. (Pubitemid 40403297)
18. Nawarycz T, Ostrowska-Nawarycz L. Rozklady centylowe obwodu pasa u dzieci i mlodziezy. (Centile charts of waist circumference for children and adolescents). Pediatr Pol 2007;82:418-24. (Pubitemid 350202113)
19. Ten S, MacLaren N. Insulin resistance syndrome in children. J Clin Endocrinol Metab 2004;89:2526-39. (Pubitemid 38766328)
20. Atabek ME, Pirgon O. Assessment of insulin sensitivity from measurements in fasting state and during an oral glucose tolerance test in obese children. J Pediatr Endocrinol Metab 2007;20:187-95. (Pubitemid 46865069)
21. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-76.
22. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med 2003; 157:821-7. (Pubitemid 36988016)
23. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
24. Feig DI, Nakagawa T, Karumanchi SA, Oliver WJ, Kang DH, Finch J, et al. Hypothesis: uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int 2004;66: 281-7. (Pubitemid 38870104)
25. Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol 2009;20:545-53.
26. Mangge H, Pilz S, Haj-Yahya S, Almer G. Uric acid indicates a high cardiovascular risk profile but is not closely associated with insulin resistance in obese adolescents. Diabetes Care 2008;31:e21.
27. Sei M, Nakatsu T, Yuasa K, Tanaka H, INDRIANI, Munakata H, Nakahori Y. Prevalence of metabolic complications in children with severe obesity. Pediatr Int 2007;49:545-52. (Pubitemid 47414911)
28. da Silva RC, Miranda WL, Chacra AR, Dib SA. Insulin resistance, beta-cell function, and glucose tolerance in Brazilian adolescents with obesity or risk factors for type 2 diabetes mellitus. J Diabetes Complications 2007;21:84-92. (Pubitemid 46321520)
29. Gil-Campos M, Aguilera CM, Cañete R, Gil A. Uric acid is associated with features of insulin resistance syndrome in obese children at prepubertal stage. Nutr Hosp 2009;24:607-13.
30. Jones DP, Richey PA, Alpert BS, Li R. Serum uric acid and ambulatory blood pressure in children with primary hypertension. Pediatr Res 2008;64:556-61.
31. Fulghesu A, Magnini R, Portoghese E, Angioni S, Minerba L, Melis GB. Obesity-related lipid profile and altered insulin incretion in adolescents with polycystic ovary syndrome. J Adolesc Health 2010;46:474-81.
32. Koulouridis E, Georgalidis K, Kostimpa I, Kalantzi M, Ntouto P, Koulouridis I, et al. Factors influencing blood pressure control in children and adolescents. Int Urol Nephrol 2008;40:741-8.
33. Lin HF, Liu CK, Liao YC, Lin RT, Chen CS, Juo SH. The risk of the metabolic syndrome on carotid thickness and stiffness: sex and age specific effects. Atherosclerosis 2009; doi: 10.1016/j.atherosclerosis.2009.11.027.
34. Yahyaoui R, Esteva I, Haro-Mora JJ, Almaraz MC, Morcillo S, Rojo-Martínez G, et al. Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons. J Clin Endocrinol Metab 2008;93:2230-3. (Pubitemid 351831539)
35. Lin JD, Chiou WK, Chang HY, Liu FH, Weng HF. Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid. Metabolism 2007;56:751-6.
36. Liou TL, Lin MW, Hsiao LC, Tsai TT, Chan WL, Ho LT, et al. Is hyperuricemia another facet of the metabolic syndrome? J Chin Med Assoc 2006;69:104-9.
37. Oyama C, Takahashi T, Oyamada M, Oyamada T, Ohno T, Miyashita M, et al. Serum uric acid as an obesity-related indicator in early adolescence. Tohoku J Exp Med 2006; 209:257-62. (Pubitemid 43905558)
38. Lean M, Han T. Fat and visceral fat: time for cardiologists to act against obesity. Br J Cardiol 2005;12:249-53.
39. Facchini F, Chen YD, Hollenbeck CB, Reaven GM. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. J Am Med Assoc 1991;266:3008-11.
40. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006;290: F625-31. (Pubitemid 43724964)
41. Matsuura F, Yamashita S, Nakamura T, Nishida M, Nozaki S, Funahashi T, et al. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism 1998;47:929-33. (Pubitemid 28364609)
42. Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 2009;154:807-13.
43. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007;86:899-906. (Pubitemid 47538288)
44. Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141:637-44.