Acute and chronic effects of hypercalcaemia on cortical excitability as studied by 5 Hz repetitive transcranial magnetic stimulation

Journal of Physiology

Volumn 589, Issue 7, 2011, Pages 1619-1626

  Iacovelli, Elisa ^a   Gilio, Francesca ^b   Mascia, Maria Lucia ^a   Scillitani, Alfredo ^c   Romagnoli, Elisabetta ^a   Pichiorri, Floriana ^a   Fucile, Sergio ^a,d   Minisola, Salvatore ^a   Inghilleri, Maurizio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SANDRO PERTINI HOSPITAL   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION;

ADULT; AGED; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN ELECTROPHYSIOLOGY; CALCIUM BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CORTICAL SILENT PERIOD; EVOKED MUSCLE RESPONSE; FEMALE; HUMAN; HYPERCALCEMIA; MALE; MUSCLE CONTRACTION; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NEUROLOGIC EXAMINATION; NEUROMUSCULAR FACILITATION; PARATHYROIDECTOMY; PRIMARY HYPERPARATHYROIDISM; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; RESTING MOTOR THRESHOLD; STIMULUS RESPONSE; TRANSCRANIAL MAGNETIC STIMULATION;

AGED; CALCIUM SIGNALING; CASE-CONTROL STUDIES; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; HYPERCALCEMIA; HYPERPARATHYROIDISM, PRIMARY; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; MOTOR CORTEX; NEURONAL PLASTICITY; PARATHYROIDECTOMY; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 79953128913     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.201111     Document Type: Article

References (29)

1. Berardelli A, Inghilleri M, Rothwell JC, Romeo S, Currà A, Gilio F, Modugno N & Manfredi M (1998). Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp Brain Res 122, 79-84.
2. Berardelli A, Inghilleri M, Gilio F, Romeo S, Pedace F, Currà A & Manfredi M (1999). Effects of repetitive cortical stimulation on the silent period evoked by magnetic stimulation. Exp Brain Res 125, 82-86.
3. Bliss TV & Collingridge GL (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
4. Carnevale V, Dionisi S, Nofroni I, Romagnoli E, Paglia F, De Geronimo S, Pepe J, Clemente G, Tonnarini G & Minisola S (2004). Potential clinical utility of a new IRMA for parathyroid hormone in postmenopausal patients with primary hyperparathyroidism. Clin Chem 50, 626-631.
5. Castilla-Guerra L, del Carmen Fernández-Moreno M, López-Chozas JM & Fernández-Bolaños R (2006). Electrolytes disturbances and seizures. Epilepsia 47, 1990-1998.
6. Castro-Alamancos MA & Connors BW (1996). Short-term synaptic enhancement and long-term potentiation in neocortex. Proc Natl Acad Sci U S A 93, 1335-1339.
7. Conte A, Gilio F, Iezzi E, Frasca V, Inghilleri M & Berardelli A (2007). Attention influences the excitability of cortical motor areas in healthy humans. Exp Brain Res 182, 109-117.
8. Corlew R, Brasier DJ, Feldman DE & Philpot BD (2008). Presynaptic NMDA receptors: newly appreciated roles in cortical synaptic function and plasticity. Neuroscientist 14, 609-625.
9. DeLorenzo RJ, Sombati S & Coulter DA (2000). Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons. Epilepsia 41, S40-44.
10. Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E & DeLorenzo RJ (2008). Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol 583, 73-83.
11. Di Lazzaro V, Oliviero A, Profice P, Pennisi MA, Pilato F, Zito G, Dileone M, Nicoletti R, Pasqualetti P & Tonali PA (2003). Ketamine increases human motor cortex excitability to transcranial magnetic stimulation. J Physiol 547, 485-496.
12. 2+ can affect the pattern of discharge in rat talami neurons. J Physiol 15, 33-45.
13. Gilio F, Conte A, Vanacore N, Frasca V, Inghilleri M & Berardelli A (2007). Excitatory and inhibitory after-effects after repetitive magnetic transcranial stimulation (rTMS) in normal subjects. Exp Brian Res 176, 588-593.
14. Gilio F, Currà A, Inghilleri M, Lorenzano C, Manfredi M & Berardelli A (2002). Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: implications for the pathophysiology of cortical function. Mov Disord 17, 467-473.
15. Inghilleri M, Berardelli A, Cruccu G & Manfredi M (1993). Silent period evoked by transcranial stimulation of the human cortex and cervicomedullary junction. J Physiol 466, 521-534.
16. Inghilleri M, Conte A, Frasca V, Curra' A, Gilio F, Manfredi M & Berardelli A (2004). Antiepileptic drugs and cortical excitability: a study with repetitive transcranial stimulation. Exp Brain Res 154, 488-493.
17. Inghilleri M, Conte A, Frasca V, Gilio F, Lorenzano C & Berardelli A (2005). Synaptic potentiation induced by rTMS: effect of lidocaine infusion. Exp Brain Res 163, 114-117.
18. Inghilleri M, Gilio F, Conte A, Frasca V, Marini Bettolo C, Iacovelli E, Gregori B, Prencipe M & Berardelli A (2006). Topiramate and cortical excitability in humans: a study with repetitive transcranial magnetic stimulation. Exp Brain Res 174, 667-672.
19. Malenka RC & Bear MF (2004). LTP and LTD: an embarrassment of riches. Neuron 44, 5-21.
20. Marx SJ (2000). Hyperparathyroid and hypoparathyroid disorders. N Engl J Med 343, 1863-1875.
21. McLean MJ & Macdonald RL (1986). Carbamazepine and 10, 11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 238, 727-738.
22. Murphy VA, Smith QR & Rapoport SI (1986). Homeostasis of brain and cerebrospinal fluid calcium concentrations during chronic hypo- and hypercalcemia. J Neurochem 47, 1735-1741.
23. 2+ signaling in spike-timing dependent plasticity. J Neurosci 26, 1101-1113.
24. Pascual-Leone A, Valls-Solé J, Wassermann EM & Hallett M (1994). Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain 117, 847-858.
25. Sastry BR, Goh JW & Auyeung A (1986). Associative induction of posttetanic and long-term potentiation in CA1 neurons of rat hippocampus. Science 232, 988-990.
26. Silverberg SJ, Lewiecki EM, Mosekilde L, Peacock M & Rubin MR (2009). Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab 94, 351-365.
27. Su H, Alroy G, Kirson ED & Yaari Y (2001). Extracellular calcium modulates persistent sodium current-dependent burst-firing in hippocampal pyramidal neurons. J Neurosci 21, 4173-4182.
28. Tai CY, Smith QR & Rapoport SI (1986). Calcium influxes into brain and cerebrospinal fluid are linearly related to plasma ionized calcium concentration. Brain Res 385, 227-236.
29. Wang T, Wang J, Cottrell JE & Kass IS (2004). Small physiologic changes in calcium and magnesium alter excitability and burst firing of CA1 pyramidal cells in rat hippocampal slices. J Neurosurg Anesthesiol 16, 201-209.