'White wave' analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion

Journal of Cell Science

Volumn 124, Issue 7, 2011, Pages 1017-1021

  Matsubayashi, Yutaka ^a   Razzell, William ^a   Martin, Paul ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Cell mobilisation; Collective migration; Myosin II; Wound healing

Indexed keywords

MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN II;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL MIGRATION; CELL MOTILITY; EPITHELIUM; IMAGE ANALYSIS; MATHEMATICAL ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; WOUND HEALING;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; EPITHELIAL CELLS; MICE; MYOSIN TYPE II; WOUND HEALING;

EID: 79953127664     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.080853     Document Type: Article

References (28)

1. Dipasquale, A. (1975). Locomotory activity of epithelial cells in culture. Exp. Cell Res. 94, 191-215.
2. Farooqui, R. and Fenteany, G. (2005). Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement. J. Cell Sci. 118, 51-63.
3. Fenteany, G., Janmey, P. A. and Stossel, T. P. (2000). Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr. Biol. 10, 831-838.
4. Friedl, P. and Gilmour, D. (2009). Collective cell migration in morphogenesis, regeneration and cancer. Nat. Rev. Mol. Cell Biol. 10, 445-457.
5. Friedl, P. and Weigelin, B. (2008). Interstitial leukocyte migration and immune function. Nat. Immunol. 9, 960-969.
6. Gutzman, J. H. and Sive, H. (2010). Epithelial relaxation mediated by the myosin phosphatase regulator Mypt1 is required for brain ventricle lumen expansion and hindbrain morphogenesis. Development 137, 795-804.
7. Hopkins, A. M., Pineda, A. D. A., Winfree, L. M., Brown, G. T., Laukoetter, M. G. and Nusrat, A. (2007). Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G806-G817.
8. Ito, M., Nakano, T., Erdodi, F. and Hartshorne, D. J. (2004). Myosin phosphatase: structure, regulation and function. Mol. Cell. Biochem. 259, 197-209.
9. Jacinto, A., Martinez-Arias, A. and Martin, P. (2001). Mechanisms of epithelial fusion and repair. Nat. Cell Biol. 3, E117-E123.
10. Lecaudey, V. and Gilmour, D. (2006). Organizing moving groups during morphogenesis. Curr. Opin. Cell Biol. 18, 102-107.
11. Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K. and Narumiya, S. (1999). Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285, 895-898.
12. 3Hthymidine in the epithelium covering skin wounds. J. Invest. Dermatol. 55, 20-25.
13. Matsubayashi, Y., Ebisuya, M., Honjoh, S. and Nishida, E. (2004). ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr. Biol. 14, 731-735.
14. Mizuno, T., Tsutsui, K. and Nishida, Y. (2002). Drosophila myosin phosphatase and its role in dorsal closure. Development 129, 1215-1223.
15. Mori, R., Power, K. T., Wang, C. H. M., Martin, P. and Becker, D. L. (2006). Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration. J. Cell Sci. 119, 5193-5203.
16. Nikolic, D. L., Boettiger, A. N., Bar-Sagi, D., Carbeck, J. D. and Shvartsman, S. Y. (2006). Role of boundary conditions in an experimental model of epithelial wound healing. Am. J. Physiol. Cell Physiol. 291, C68-C75.
17. Ostap, E. M. (2002). 2,3-Butanedione monoxime (BDM) as a myosin inhibitor. J. Muscle Res. Cell Motil. 23, 305-308.
18. Petitjean, L., Reffay, M., Grasland-Mongrain, E., Poujade, M., Ladoux, B., Buguin, A. and Silberzan, P. (2010). Velocity fields in a collectively migrating epithelium. Biophys. J. 98, 1790-1800.
19. Poujade, M., Grasland-Mongrain, E., Hertzog, A., Jouanneau, J., Chavrier, P., Ladoux, B., Buguin, A. and Silberzan, P. (2007). Collective migration of an epithelial monolayer in response to a model wound. Proc. Natl. Acad. Sci. USA 104, 15988-15993.
20. Rauchman, M. I., Nigam, S. K., Delpire, E. and Gullans, S. R. (1993). An osmotically tolerant inner medullary collecting duct cell-line from an Sv40 transgenic mouse. Am. J. Physiol. 265, F416-F424.
21. Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., Parsons, J. T. and Horwitz, A. R. (2003). Cell migration: integrating signals from front to back. Science 302, 1704-1709.
22. Rorth, P. (2009). Collective cell migration. Annu. Rev. Cell Dev. Biol. 25, 407-429.
23. Sahai, E. (2005). Mechanisms of cancer cell invasion. Curr. Opin. Genet. Dev. 15, 87-96.
24. Shaw, T. and Martin, P. (2009). Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep. 10, 881-886.
25. Singer, A. J. and Dagum, A. B. (2009). Current management of acute cutaneous wounds. N. Eng. J. Med. 359, 1037-1046.
26. Tanner, K., Ferris, D. R., Lanzano, L., Mandefro, B., Mantulin, W. W., Gardiner, D. M., Rugg, E. L. and Gratton, E. (2009). Coherent movement of cell layers during wound healing by image correlation spectroscopy. Biophys. J. 97, 2098-2106.
27. Trepat, X., Wasserman, M. R., Angelini, T. E., Millet, E., Weitz, D. A., Butler, J. P. and Fredberg, J. J. (2009). Physical forces during collective cell migration. Nat. Phys. 5, 426-430.
28. Vitorino, P. and Meyer, T. (2008). Modular control of endothelial sheet migration. Genes Dev. 22, 3268-3281.