메뉴 건너뛰기




Volumn 9, Issue , 2011, Pages

The influence of CYP 2C19*2 polymorphism on platelet function testing during single antiplatelet treatment with clopidogrel

Author keywords

Clopidogrel resistanceFunctional testsVerifyNow methodVASP method; Genetic polymorphisms

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; CYTOCHROME P450 2C19; VASODILATOR STIMULATED PHOSPHOPROTEIN;

EID: 79953124485     PISSN: None     EISSN: 14779560     Source Type: Journal    
DOI: 10.1186/1477-9560-9-4     Document Type: Article
Times cited : (30)

References (45)
  • 1
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • 10.1136/bmj.324.7329.71, 64503, 11786451
    • Collaboration AT. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002, 324:71-86. 10.1136/bmj.324.7329.71, 64503, 11786451.
    • (2002) BMJ , vol.324 , pp. 71-86
    • Collaboration, A.T.1
  • 2
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation; the CURE trial
    • 10.1056/NEJMoa010746, 11519503
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation; the CURE trial. N Engl J Med 2001, 345:494-502. 10.1056/NEJMoa010746, 11519503.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 3
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    • 10.1016/S0140-6736(01)05701-4, 11520521
    • Mehta SR, Yusuf S, Peters RJ, Bertrand ME, Lewis BS, Natarajan MK, Malmberg K, Rupprecht H, Zhao F, Chrolavicius S, Copland I, Fox KA. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001, 358:527-533. 10.1016/S0140-6736(01)05701-4, 11520521.
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3    Bertrand, M.E.4    Lewis, B.S.5    Natarajan, M.K.6    Malmberg, K.7    Rupprecht, H.8    Zhao, F.9    Chrolavicius, S.10    Copland, I.11    Fox, K.A.12
  • 5
    • 11844256436 scopus 로고    scopus 로고
    • Variability in platelet responsiveness to clopidogrel among 544 individuals
    • 10.1016/j.jacc.2004.09.067, 15653023
    • Serebruany VL, Steinhubl SR, Berger PB, Malinin AI, Bhatt DL, Topol EJ. Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 2005, 45:246-251. 10.1016/j.jacc.2004.09.067, 15653023.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 246-251
    • Serebruany, V.L.1    Steinhubl, S.R.2    Berger, P.B.3    Malinin, A.I.4    Bhatt, D.L.5    Topol, E.J.6
  • 6
    • 17144370263 scopus 로고    scopus 로고
    • Resistance to clopidogrel: a review of the evidence
    • 10.1016/j.jacc.2005.01.034, 15837243
    • Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: a review of the evidence. J Am Coll Cardiol 2005, 45:1157-1164. 10.1016/j.jacc.2005.01.034, 15837243.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1157-1164
    • Nguyen, T.A.1    Diodati, J.G.2    Pharand, C.3
  • 7
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • 10.1161/01.CIR.0000130846.46168.03, 15184279
    • Matetzky S, Shenkman B, Guetta V, Shechter M, Bienart R, Goldenberg I, Novikov I, Pres H, Savion N, Varon D, Hod H. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004, 109:3171-3175. 10.1161/01.CIR.0000130846.46168.03, 15184279.
    • (2004) Circulation , vol.109 , pp. 3171-3175
    • Matetzky, S.1    Shenkman, B.2    Guetta, V.3    Shechter, M.4    Bienart, R.5    Goldenberg, I.6    Novikov, I.7    Pres, H.8    Savion, N.9    Varon, D.10    Hod, H.11
  • 10
    • 65249145201 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
    • 10.1093/eurheartj/ehp041, 19193675
    • Sibbing D, Stegherr J, Latz W, Koch W, Mehilli J, Dörrler K, Morath T, Schömig A, Kastrati A, von Beckerath N. Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention. Eur Heart J 2009, 30:916-922. 10.1093/eurheartj/ehp041, 19193675.
    • (2009) Eur Heart J , vol.30 , pp. 916-922
    • Sibbing, D.1    Stegherr, J.2    Latz, W.3    Koch, W.4    Mehilli, J.5    Dörrler, K.6    Morath, T.7    Schömig, A.8    Kastrati, A.9    von Beckerath, N.10
  • 14
    • 34249939815 scopus 로고    scopus 로고
    • Measuring antiplatelet drug effects in the laboratory
    • 10.1016/j.thromres.2006.11.012, 17239428
    • Harrison P, Frelinger A, Furman MI, Michelson AD. Measuring antiplatelet drug effects in the laboratory. Thromb Res 2007, 120:323-336. 10.1016/j.thromres.2006.11.012, 17239428.
    • (2007) Thromb Res , vol.120 , pp. 323-336
    • Harrison, P.1    Frelinger, A.2    Furman, M.I.3    Michelson, A.D.4
  • 15
    • 34047096264 scopus 로고    scopus 로고
    • Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives
    • 10.1016/j.jacc.2006.11.044, 17418288
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Alfonso F, Macaya C, Bass TA, Costa MA. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol 2007, 49:1505-1516. 10.1016/j.jacc.2006.11.044, 17418288.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1505-1516
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3    Alfonso, F.4    Macaya, C.5    Bass, T.A.6    Costa, M.A.7
  • 16
    • 77949776136 scopus 로고    scopus 로고
    • Impact of P2Y12-ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients
    • 10.1016/j.thromres.2009.10.014, 19914687
    • Bonello L, Bonello-Palot N, Armero S, Bonello C, Mokhtar OA, Arques S, Dignat-George F, Camoin-Jau L, Paganelli F. Impact of P2Y12-ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients. Thromb Res 2010, 125:e167-70. 10.1016/j.thromres.2009.10.014, 19914687.
    • (2010) Thromb Res , vol.125
    • Bonello, L.1    Bonello-Palot, N.2    Armero, S.3    Bonello, C.4    Mokhtar, O.A.5    Arques, S.6    Dignat-George, F.7    Camoin-Jau, L.8    Paganelli, F.9
  • 17
    • 15944383861 scopus 로고    scopus 로고
    • Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases
    • 10.1111/j.1538-7836.2004.01063.x, 15634270
    • Aleil B, Ravanat C, Cazenave JP, Rochoux G, Heitz A, Gachet C. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005, 3:85-92. 10.1111/j.1538-7836.2004.01063.x, 15634270.
    • (2005) J Thromb Haemost , vol.3 , pp. 85-92
    • Aleil, B.1    Ravanat, C.2    Cazenave, J.P.3    Rochoux, G.4    Heitz, A.5    Gachet, C.6
  • 18
    • 33646561025 scopus 로고    scopus 로고
    • Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study
    • 10.1016/j.jacc.2005.12.084, 17161243
    • Gurbel PA, Bliden KP, Tantry US. Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study. J Am Coll Cardiol 2006, 48:2186-2191. 10.1016/j.jacc.2005.12.084, 17161243.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 2186-2191
    • Gurbel, P.A.1    Bliden, K.P.2    Tantry, U.S.3
  • 19
    • 14944378655 scopus 로고    scopus 로고
    • Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study
    • 10.1161/01.CIR.0000157138.02645.11, 15738352
    • Gurbel PA, Bliden KP, Zaman KA, Yoho JA, Hayes KM, Tantry US. Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation 2005, 111:1153-1159. 10.1161/01.CIR.0000157138.02645.11, 15738352.
    • (2005) Circulation , vol.111 , pp. 1153-1159
    • Gurbel, P.A.1    Bliden, K.P.2    Zaman, K.A.3    Yoho, J.A.4    Hayes, K.M.5    Tantry, U.S.6
  • 20
    • 12344294328 scopus 로고    scopus 로고
    • Unstable angina, stroke, myocardial infarction and death in aspirin non-responders. A prospective, randomized trial. The ASCET (ASpirin non-responsiveness and Clopidogrel Endpoint Trial) design
    • 10.1080/14017430410024324, 15804802
    • Pettersen AA, Seljeflot I, Abdelnoor M, Arnesen H. Unstable angina, stroke, myocardial infarction and death in aspirin non-responders. A prospective, randomized trial. The ASCET (ASpirin non-responsiveness and Clopidogrel Endpoint Trial) design. Scand Cardiovasc J 2004, 38:353-356. 10.1080/14017430410024324, 15804802.
    • (2004) Scand Cardiovasc J , vol.38 , pp. 353-356
    • Pettersen, A.A.1    Seljeflot, I.2    Abdelnoor, M.3    Arnesen, H.4
  • 21
    • 0032873146 scopus 로고    scopus 로고
    • Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets--definition and detection of ticlopidine/clopidogrel effects
    • Schwarz UR, Geiger J, Walter U, Eigenthaler M. Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets--definition and detection of ticlopidine/clopidogrel effects. Thromb Haemost 1999, 82:1145-1152.
    • (1999) Thromb Haemost , vol.82 , pp. 1145-1152
    • Schwarz, U.R.1    Geiger, J.2    Walter, U.3    Eigenthaler, M.4
  • 22
    • 77149128031 scopus 로고    scopus 로고
    • VerifyNow and VASP phosphorylation assays give similar results for patients receiving clopidogrel, but they do not always correlate with platelet aggregation
    • 10.3109/09537100903437206, 20148735
    • Bidet A, Jais C, Puymirat E, Coste P, Nurden A, Jakubowski J, Nurden P. VerifyNow and VASP phosphorylation assays give similar results for patients receiving clopidogrel, but they do not always correlate with platelet aggregation. Platelets 2010, 21:94-100. 10.3109/09537100903437206, 20148735.
    • (2010) Platelets , vol.21 , pp. 94-100
    • Bidet, A.1    Jais, C.2    Puymirat, E.3    Coste, P.4    Nurden, A.5    Jakubowski, J.6    Nurden, P.7
  • 24
    • 67649370752 scopus 로고    scopus 로고
    • Relation of genetic polymorphisms in the cytochrome P450 gene with clopidogrel resistance after drug-eluting stent implantation in Koreans
    • 10.1016/j.amjcard.2009.02.045, 19576320
    • Lee JM, Park S, Shin DJ, Choi D, Shim CY, Ko YG, Kim JS, Shin ES, Chang CW, Lee JE, Jang Y. Relation of genetic polymorphisms in the cytochrome P450 gene with clopidogrel resistance after drug-eluting stent implantation in Koreans. Am J Cardiol 2009, 104:46-51. 10.1016/j.amjcard.2009.02.045, 19576320.
    • (2009) Am J Cardiol , vol.104 , pp. 46-51
    • Lee, J.M.1    Park, S.2    Shin, D.J.3    Choi, D.4    Shim, C.Y.5    Ko, Y.G.6    Kim, J.S.7    Shin, E.S.8    Chang, C.W.9    Lee, J.E.10    Jang, Y.11
  • 25
    • 78049465814 scopus 로고    scopus 로고
    • Impact of loading dose adjustment on platelet reactivity in homozygotes of the 2C19 2* loss of function polymorphism
    • 10.1016/j.ijcard.2009.07.033, 19712984
    • Bonello L, Palot-Bonello N, Armero S, Camoin-Jau L, Paganelli F. Impact of loading dose adjustment on platelet reactivity in homozygotes of the 2C19 2* loss of function polymorphism. Int J Cardiol 2010, 145(1):165-166. 10.1016/j.ijcard.2009.07.033, 19712984.
    • (2010) Int J Cardiol , vol.145 , Issue.1 , pp. 165-166
    • Bonello, L.1    Palot-Bonello, N.2    Armero, S.3    Camoin-Jau, L.4    Paganelli, F.5
  • 27
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • 10.1161/CIRCULATIONAHA.109.885194, 20083681
    • Sibbing D, Koch W, Gebhard D, Schuster T, Braun S, Stegherr J, Morath T, Schömig A, von Beckerath N, Kastrati A. Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 2010, 121:512-518. 10.1161/CIRCULATIONAHA.109.885194, 20083681.
    • (2010) Circulation , vol.121 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3    Schuster, T.4    Braun, S.5    Stegherr, J.6    Morath, T.7    Schömig, A.8    von Beckerath, N.9    Kastrati, A.10
  • 28
    • 78650952436 scopus 로고    scopus 로고
    • Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease
    • 10.1111/j.1538-7836.2010.04115.x, 20955349
    • Grove EL, Hvas AM, Mortensen SB, Larsen SB, Kristensen SD. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Haemost 2011, 9:185-191. 10.1111/j.1538-7836.2010.04115.x, 20955349.
    • (2011) J Thromb Haemost , vol.9 , pp. 185-191
    • Grove, E.L.1    Hvas, A.M.2    Mortensen, S.B.3    Larsen, S.B.4    Kristensen, S.D.5
  • 29
    • 45249088224 scopus 로고    scopus 로고
    • The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance
    • 10.1038/clpt.2008.20, 18323861
    • Kim KA, Park PW, Hong SJ, Park JY. The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance. Clin Pharmacol Ther 2008, 84:236-242. 10.1038/clpt.2008.20, 18323861.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 236-242
    • Kim, K.A.1    Park, P.W.2    Hong, S.J.3    Park, J.Y.4
  • 30
    • 34548075511 scopus 로고    scopus 로고
    • Different methodologies for evaluating the effect of clopidogrel on platelet function in high-risk coronary artery disease patients
    • 10.1111/j.1538-7836.2007.02656.x, 17723123
    • Paniccia R, Antonucci E, Gori AM, Marcucci R, Giglioli C, Antoniucci D, Gensini GF, Abbate R, Prisco D. Different methodologies for evaluating the effect of clopidogrel on platelet function in high-risk coronary artery disease patients. J Thromb Haemost 2007, 5:1839-1847. 10.1111/j.1538-7836.2007.02656.x, 17723123.
    • (2007) J Thromb Haemost , vol.5 , pp. 1839-1847
    • Paniccia, R.1    Antonucci, E.2    Gori, A.M.3    Marcucci, R.4    Giglioli, C.5    Antoniucci, D.6    Gensini, G.F.7    Abbate, R.8    Prisco, D.9
  • 31
    • 78650317150 scopus 로고    scopus 로고
    • Genetic variability in response to clopidogrel therapy: clinical implications
    • 10.1093/eurheartj/ehq329, 20846994
    • Huber K. Genetic variability in response to clopidogrel therapy: clinical implications. Eur Heart J 2010, 31:2974-2976. 10.1093/eurheartj/ehq329, 20846994.
    • (2010) Eur Heart J , vol.31 , pp. 2974-2976
    • Huber, K.1
  • 32
    • 58249137117 scopus 로고    scopus 로고
    • Clopidogrel in acute coronary syndrome: to genotype or not?
    • 10.1016/S0140-6736(08)61846-2, 19108882
    • Storey RF. Clopidogrel in acute coronary syndrome: to genotype or not?. Lancet 2009, 373:276-278. 10.1016/S0140-6736(08)61846-2, 19108882.
    • (2009) Lancet , vol.373 , pp. 276-278
    • Storey, R.F.1
  • 34
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • 10.1016/j.jacc.2007.06.064, 18206732
    • Gilard M, Arnaud B, Cornily JC, Le Gal G, Lacut K, Le Calvez G, Mansourati J, Mottier D, Abgrall JF, Boschat J. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol 2008, 51:256-260. 10.1016/j.jacc.2007.06.064, 18206732.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3    Le Gal, G.4    Lacut, K.5    Le Calvez, G.6    Mansourati, J.7    Mottier, D.8    Abgrall, J.F.9    Boschat, J.10
  • 35
    • 78650048685 scopus 로고    scopus 로고
    • Cytochrome 2C19 polymorphism and response to adjunctive cilostazol versus high maintenance-dose clopidogrel in patients undergoing percutaneous coronary intervention
    • 10.1161/CIRCINTERVENTIONS.110.949859, 20823393
    • Hwang SJ, Jeong YH, Kim IS, Park KS, Kang MK, Koh JS, Park JR, Park Y, Koh EH, Kwak CH, Hwang JY, Kim S. Cytochrome 2C19 polymorphism and response to adjunctive cilostazol versus high maintenance-dose clopidogrel in patients undergoing percutaneous coronary intervention. Circ Cardiovasc Interv 2010, 3:450-459. 10.1161/CIRCINTERVENTIONS.110.949859, 20823393.
    • (2010) Circ Cardiovasc Interv , vol.3 , pp. 450-459
    • Hwang, S.J.1    Jeong, Y.H.2    Kim, I.S.3    Park, K.S.4    Kang, M.K.5    Koh, J.S.6    Park, J.R.7    Park, Y.8    Koh, E.H.9    Kwak, C.H.10    Hwang, J.Y.11    Kim, S.12
  • 36
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    • 10.1161/01.CIR.0000112378.09325.F9, 14707025
    • Lau WC, Gurbel PA, Watkins PB, Neer CJ, Hopp AS, Carville DG, Guyer KE, Tait AR, Bates ER. Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation 2004, 109:166-171. 10.1161/01.CIR.0000112378.09325.F9, 14707025.
    • (2004) Circulation , vol.109 , pp. 166-171
    • Lau, W.C.1    Gurbel, P.A.2    Watkins, P.B.3    Neer, C.J.4    Hopp, A.S.5    Carville, D.G.6    Guyer, K.E.7    Tait, A.R.8    Bates, E.R.9
  • 37
    • 65349111293 scopus 로고    scopus 로고
    • The drug-drug interaction between proton pump inhibitors and clopidogrel
    • 10.1503/cmaj.090251, 2659824, 19332744
    • Lau WC, Gurbel PA. The drug-drug interaction between proton pump inhibitors and clopidogrel. CMAJ 2009, 180:699-700. 10.1503/cmaj.090251, 2659824, 19332744.
    • (2009) CMAJ , vol.180 , pp. 699-700
    • Lau, W.C.1    Gurbel, P.A.2
  • 38
    • 54349121974 scopus 로고    scopus 로고
    • Calcium-channel blockers reduce the antiplatelet effect of clopidogrel
    • 10.1016/j.jacc.2008.07.055, 19007592
    • Siller-Matula JM, Lang I, Christ G, Jilma B. Calcium-channel blockers reduce the antiplatelet effect of clopidogrel. J Am Coll Cardiol 2008, 52:1557-1563. 10.1016/j.jacc.2008.07.055, 19007592.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1557-1563
    • Siller-Matula, J.M.1    Lang, I.2    Christ, G.3    Jilma, B.4
  • 40
    • 76149100609 scopus 로고    scopus 로고
    • Calcium-channel blockers decrease clopidogrel-mediated platelet inhibition
    • 10.1136/hrt.2009.171488, 19687016
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW. Calcium-channel blockers decrease clopidogrel-mediated platelet inhibition. Heart 2010, 96:186-189. 10.1136/hrt.2009.171488, 19687016.
    • (2010) Heart , vol.96 , pp. 186-189
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 43
    • 33645891168 scopus 로고    scopus 로고
    • The influence of body mass index on outcomes and the benefit of antiplatelet therapy following percutaneous coronary intervention
    • Kelly RV, Hsu A, Topol E, Steinhubl S. The influence of body mass index on outcomes and the benefit of antiplatelet therapy following percutaneous coronary intervention. J Invasive Cardiol 2006, 18:115-119.
    • (2006) J Invasive Cardiol , vol.18 , pp. 115-119
    • Kelly, R.V.1    Hsu, A.2    Topol, E.3    Steinhubl, S.4
  • 44
    • 70349868299 scopus 로고    scopus 로고
    • Smoking promotes clopidogrel-mediated platelet inhibition in patients receiving dual antiplatelet therapy
    • 10.1016/j.thromres.2009.06.012, 19631365
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW. Smoking promotes clopidogrel-mediated platelet inhibition in patients receiving dual antiplatelet therapy. Thromb Res 2009, 124:588-591. 10.1016/j.thromres.2009.06.012, 19631365.
    • (2009) Thromb Res , vol.124 , pp. 588-591
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 45
    • 63549115843 scopus 로고    scopus 로고
    • Interaction between cigarette smoking and clinical benefit of clopidogrel
    • 10.1016/j.jacc.2008.12.044, 2675920, 19358940
    • Desai NR, Mega JL, Jiang S, Cannon CP, Sabatine MS. Interaction between cigarette smoking and clinical benefit of clopidogrel. J Am Coll Cardiol 2009, 53:1273-1278. 10.1016/j.jacc.2008.12.044, 2675920, 19358940.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1273-1278
    • Desai, N.R.1    Mega, J.L.2    Jiang, S.3    Cannon, C.P.4    Sabatine, M.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.