메뉴 건너뛰기




Volumn 20, Issue 8, 2011, Pages 1524-1535

FGFR3 is a target of the homeobox transcription factor SHOX in limb development

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3; LUCIFERASE; SHORT STATURE HOMEOBOX PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 79953111544     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr030     Document Type: Article
Times cited : (42)

References (57)
  • 2
    • 33748967708 scopus 로고    scopus 로고
    • Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements
    • Tiecke, E., Bangs, F., Blaschke, R., Farrell, E.R., Rappold, G. and Tickle, C. (2006) Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev. Biol., 298, 585-596.
    • (2006) Dev. Biol. , vol.298 , pp. 585-596
    • Tiecke, E.1    Bangs, F.2    Blaschke, R.3    Farrell, E.R.4    Rappold, G.5    Tickle, C.6
  • 5
    • 4344560627 scopus 로고    scopus 로고
    • The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes
    • Marchini, A., Marttila, T., Winter, A., Caldeira, S., Malanchi, I., Blaschke, R.J., Hacker, B., Rao, E., Karperien, M., Wit, J.M. et al. (2004) The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes. J. Biol. Chem., 279, 37103-37114.
    • (2004) J. Biol. Chem. , vol.279 , pp. 37103-37114
    • Marchini, A.1    Marttila, T.2    Winter, A.3    Caldeira, S.4    Malanchi, I.5    Blaschke, R.J.6    Hacker, B.7    Rao, E.8    Karperien, M.9    Wit, J.M.10
  • 6
    • 0030940217 scopus 로고    scopus 로고
    • Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome
    • Rao, E., Weiss, B., Fukami, M., Rump, A., Niesler, B., Mertz, A., Muroya, K., Binder, G., Kirsch, S., Winkelmann, M. et al. (1997) Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat. Genet., 16, 54-63.
    • (1997) Nat. Genet. , vol.16 , pp. 54-63
    • Rao, E.1    Weiss, B.2    Fukami, M.3    Rump, A.4    Niesler, B.5    Mertz, A.6    Muroya, K.7    Binder, G.8    Kirsch, S.9    Winkelmann, M.10
  • 12
    • 72749122013 scopus 로고    scopus 로고
    • Enhancer deletions of the SHOX gene as a frequent cause of short stature: the essential role of a 250 kb downstream regulatory domain
    • Chen, J., Wildhardt, G., Zhong, Z., Roth, R., Weiss, B., Steinberger, D., Decker, J., Blum, W.F. and Rappold, G. (2009) Enhancer deletions of the SHOX gene as a frequent cause of short stature: the essential role of a 250 kb downstream regulatory domain. J. Med. Genet., 46, 834-839.
    • (2009) J. Med. Genet. , vol.46 , pp. 834-839
    • Chen, J.1    Wildhardt, G.2    Zhong, Z.3    Roth, R.4    Weiss, B.5    Steinberger, D.6    Decker, J.7    Blum, W.F.8    Rappold, G.9
  • 15
    • 33749245482 scopus 로고    scopus 로고
    • High incidence of SHOX anomalies in individuals with short stature
    • Huber, C., Rosilio, M., Munnich, A. and Cormier-Daire, V. (2006) High incidence of SHOX anomalies in individuals with short stature. J. Med. Genet., 43, 735-739.
    • (2006) J. Med. Genet. , vol.43 , pp. 735-739
    • Huber, C.1    Rosilio, M.2    Munnich, A.3    Cormier-Daire, V.4
  • 18
    • 0024240142 scopus 로고
    • Ultrasonographic prenatal diagnosis and fetal pathology of Langer mesomelic dwarfism
    • Evans, M.I., Zador, I.E., Qureshi, F., Budev, H., Quigg, M.H. and Nadler, H.L. (1988) Ultrasonographic prenatal diagnosis and fetal pathology of Langer mesomelic dwarfism. Am. J. Med. Genet., 31, 915-920.
    • (1988) Am. J. Med. Genet. , vol.31 , pp. 915-920
    • Evans, M.I.1    Zador, I.E.2    Qureshi, F.3    Budev, H.4    Quigg, M.H.5    Nadler, H.L.6
  • 19
  • 20
    • 33846617772 scopus 로고    scopus 로고
    • Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients
    • Sabherwal, N., Bangs, F., Roth, R., Weiss, B., Jantz, K., Tiecke, E., Hinkel, G.K., Spaich, C., Hauffa, B.P., van der Kamp, H. et al. (2007) Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients. Hum. Mol. Genet., 16, 210-222.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 210-222
    • Sabherwal, N.1    Bangs, F.2    Roth, R.3    Weiss, B.4    Jantz, K.5    Tiecke, E.6    Hinkel, G.K.7    Spaich, C.8    Hauffa, B.P.9    van der Kamp, H.10
  • 22
    • 0034456564 scopus 로고    scopus 로고
    • Short stature homeobox-containing gene duplication on the der(X) chromosome in a female with 45,X/46,X, der(X), gonadal dysgenesis, and tall stature
    • Ogata, T., Kosho, T., Wakui, K., Fukushima, Y., Yoshimoto, M. and Miharu, N. (2000) Short stature homeobox-containing gene duplication on the der(X) chromosome in a female with 45,X/46,X, der(X), gonadal dysgenesis, and tall stature. J. Clin. Endocrinol. Metab., 85, 2927-2930.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 2927-2930
    • Ogata, T.1    Kosho, T.2    Wakui, K.3    Fukushima, Y.4    Yoshimoto, M.5    Miharu, N.6
  • 23
    • 0033051415 scopus 로고    scopus 로고
    • High density micromass cultures of embryonic limb bud mesenchymal cells: an in vitro model of endochondral skeletal development
    • Mello, M.A. and Tuan, R.S. (1999) High density micromass cultures of embryonic limb bud mesenchymal cells: an in vitro model of endochondral skeletal development. In Vitro Cell. Dev. Biol. Anim., 35, 262-269.
    • (1999) Vitro Cell. Dev. Biol. Anim. , vol.35 , pp. 262-269
    • Mello, M.A.1    Tuan, R.S.2
  • 24
    • 0017739437 scopus 로고
    • Stage-related capacity for limb chondrogenesis in cell culture
    • Ahrens, P.B., Solursh, M. and Reiter, R.S. (1977) Stage-related capacity for limb chondrogenesis in cell culture. Dev. Biol., 60, 69-82.
    • (1977) Dev. Biol. , vol.60 , pp. 69-82
    • Ahrens, P.B.1    Solursh, M.2    Reiter, R.S.3
  • 25
    • 22144457621 scopus 로고    scopus 로고
    • Alteration of DNA binding, dimerization, and nuclear translocation of SHOX homeodomain mutations identified in idiopathic short stature and Leri-Weill dyschondrosteosis
    • Schneider, K.U., Marchini, A., Sabherwal, N., Roth, R., Niesler, B., Marttila, T., Blaschke, R.J., Lawson, M., Dumic, M. and Rappold, G. (2005) Alteration of DNA binding, dimerization, and nuclear translocation of SHOX homeodomain mutations identified in idiopathic short stature and Leri-Weill dyschondrosteosis. Hum. Mutat., 26, 44-52.
    • (2005) Hum. Mutat. , vol.26 , pp. 44-52
    • Schneider, K.U.1    Marchini, A.2    Sabherwal, N.3    Roth, R.4    Niesler, B.5    Marttila, T.6    Blaschke, R.J.7    Lawson, M.8    Dumic, M.9    Rappold, G.10
  • 27
    • 0035894660 scopus 로고    scopus 로고
    • The Leri-Weill and Turner syndrome homeobox gene SHOX encodes a cell-type specific transcriptional activator
    • Rao, E., Blaschke, R.J., Marchini, A., Niesler, B., Burnett, M. and Rappold, G.A. (2001) The Leri-Weill and Turner syndrome homeobox gene SHOX encodes a cell-type specific transcriptional activator. Hum. Mol. Genet., 10, 3083-3091.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 3083-3091
    • Rao, E.1    Blaschke, R.J.2    Marchini, A.3    Niesler, B.4    Burnett, M.5    Rappold, G.A.6
  • 28
    • 63849103182 scopus 로고    scopus 로고
    • The RCAS retroviral expression system in the study of skeletal development
    • Gordon, C.T., Rodda, F.A. and Farlie, P.G. (2009) The RCAS retroviral expression system in the study of skeletal development. Dev. Dyn., 238, 797-811.
    • (2009) Dev. Dyn. , vol.238 , pp. 797-811
    • Gordon, C.T.1    Rodda, F.A.2    Farlie, P.G.3
  • 29
    • 0036569779 scopus 로고    scopus 로고
    • Role of Runx genes in chondrocyte differentiation
    • Stricker, S., Fundele, R., Vortkamp, A. and Mundlos, S. (2002) Role of Runx genes in chondrocyte differentiation. Dev. Biol., 245, 95-108.
    • (2002) Dev. Biol. , vol.245 , pp. 95-108
    • Stricker, S.1    Fundele, R.2    Vortkamp, A.3    Mundlos, S.4
  • 31
    • 77951874066 scopus 로고    scopus 로고
    • Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers
    • Gotea, V., Visel, A., Westlund, J.M., Nobrega, M.A., Pennacchio, L.A. and Ovcharenko, I. (2010) Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers. Genome Res., 20, 565-577.
    • (2010) Genome Res. , vol.20 , pp. 565-577
    • Gotea, V.1    Visel, A.2    Westlund, J.M.3    Nobrega, M.A.4    Pennacchio, L.A.5    Ovcharenko, I.6
  • 32
    • 0033767384 scopus 로고    scopus 로고
    • Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases
    • Saleh, M., Rambaldi, I., Yang, X.J. and Featherstone, M.S. (2000) Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. Mol. Cell. Biol., 20, 8623-8633.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8623-8633
    • Saleh, M.1    Rambaldi, I.2    Yang, X.J.3    Featherstone, M.S.4
  • 33
    • 33748416500 scopus 로고    scopus 로고
    • Hox transcription factors and their elusive mammalian gene targets
    • Svingen, T. and Tonissen, K.F. (2006) Hox transcription factors and their elusive mammalian gene targets. Heredity, 97, 88-96.
    • (2006) Heredity , vol.97 , pp. 88-96
    • Svingen, T.1    Tonissen, K.F.2
  • 34
    • 77958540480 scopus 로고    scopus 로고
    • Cell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elements
    • Zarnegar, M.A., Chen, J. and Rothenberg, E.V. (2010) Cell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elements. Mol. Cell. Biol., 30, 4922-4939.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 4922-4939
    • Zarnegar, M.A.1    Chen, J.2    Rothenberg, E.V.3
  • 36
    • 0032570693 scopus 로고    scopus 로고
    • Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors
    • McEwen, D.G. and Ornitz, D.M. (1998) Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors. J. Biol. Chem., 273, 5349-5357.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5349-5357
    • McEwen, D.G.1    Ornitz, D.M.2
  • 37
    • 31944443701 scopus 로고    scopus 로고
    • Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis
    • Shin, J.W., Min, M., Larrieu-Lahargue, F., Canron, X., Kunstfeld, R., Nguyen, L., Henderson, J.E., Bikfalvi, A., Detmar, M. and Hong, Y.K. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol. Biol. Cell, 17, 576-584.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 576-584
    • Shin, J.W.1    Min, M.2    Larrieu-Lahargue, F.3    Canron, X.4    Kunstfeld, R.5    Nguyen, L.6    Henderson, J.E.7    Bikfalvi, A.8    Detmar, M.9    Hong, Y.K.10
  • 38
    • 67651151314 scopus 로고    scopus 로고
    • Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression
    • Sun, F., Chen, Q., Yang, S., Pan, Q., Ma, J., Wan, Y., Chang, C.H. and Hong, A. (2009) Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression. Nucleic Acids Res., 37, 3897-3911.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 3897-3911
    • Sun, F.1    Chen, Q.2    Yang, S.3    Pan, Q.4    Ma, J.5    Wan, Y.6    Chang, C.H.7    Hong, A.8
  • 39
    • 77949538773 scopus 로고    scopus 로고
    • Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes
    • Tan, C.C., Walsh, M.J. and Gelb, B.D. (2009) Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes. PLoS One, 4, e8535.
    • (2009) PLoS One , vol.4
    • Tan, C.C.1    Walsh, M.J.2    Gelb, B.D.3
  • 42
    • 0034142212 scopus 로고    scopus 로고
    • Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis
    • Plowright, E.E., Li, Z., Bergsagel, P.L., Chesi, M., Barber, D.L., Branch, D.R., Hawley, R.G. and Stewart, A.K. (2000) Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood, 95, 992-998.
    • (2000) Blood , vol.95 , pp. 992-998
    • Plowright, E.E.1    Li, Z.2    Bergsagel, P.L.3    Chesi, M.4    Barber, D.L.5    Branch, D.R.6    Hawley, R.G.7    Stewart, A.K.8
  • 44
    • 34548407864 scopus 로고    scopus 로고
    • FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
    • Tomlinson, D.C., Baldo, O., Harnden, P. and Knowles, M.A. (2007) FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J. Pathol., 213, 91-98.
    • (2007) J. Pathol. , vol.213 , pp. 91-98
    • Tomlinson, D.C.1    Baldo, O.2    Harnden, P.3    Knowles, M.A.4
  • 45
    • 0034234569 scopus 로고    scopus 로고
    • A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos
    • Iwata, T., Chen, L., Li, C., Ovchinnikov, D.A., Behringer, R.R., Francomano, C.A. and Deng, C.X. (2000) A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum. Mol. Genet., 9, 1603-1613.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1603-1613
    • Iwata, T.1    Chen, L.2    Li, C.3    Ovchinnikov, D.A.4    Behringer, R.R.5    Francomano, C.A.6    Deng, C.X.7
  • 48
    • 0029935895 scopus 로고    scopus 로고
    • Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
    • Naski, M.C., Wang, Q., Xu, J. and Ornitz, D.M. (1996) Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat. Genet., 13, 233-237.
    • (1996) Nat. Genet. , vol.13 , pp. 233-237
    • Naski, M.C.1    Wang, Q.2    Xu, J.3    Ornitz, D.M.4
  • 50
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A. and Leder, P. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell, 84, 911-921.
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 51
    • 34247261472 scopus 로고    scopus 로고
    • Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3
    • Eswarakumar, V.P. and Schlessinger, J. (2007) Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc. Natl Acad. Sci. USA, 104, 3937-3942.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 3937-3942
    • Eswarakumar, V.P.1    Schlessinger, J.2
  • 53
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M.W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res., 29, e45.
    • (2001) Nucleic Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 54
    • 67649834440 scopus 로고    scopus 로고
    • ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions
    • Schmidt, D., Wilson, M.D., Spyrou, C., Brown, G.D., Hadfield, J. and Odom, D.T. (2009) ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods, 48, 240-248.
    • (2009) Methods , vol.48 , pp. 240-248
    • Schmidt, D.1    Wilson, M.D.2    Spyrou, C.3    Brown, G.D.4    Hadfield, J.5    Odom, D.T.6
  • 55
    • 33845925394 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation and microarray-based analysis of protein location
    • Lee, T.I., Johnstone, S.E. and Young, R.A. (2006) Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat. Protoc., 1, 729-748.
    • (2006) Nat. Protoc. , vol.1 , pp. 729-748
    • Lee, T.I.1    Johnstone, S.E.2    Young, R.A.3
  • 56
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
    • Langmead, B., Trapnell, C., Pop, M. and Salzberg, S.L. (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol., 10, R25.
    • (2009) Genome Biol. , vol.10
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.