Hypoglycemic activity of C-glycosyl flavonoid from Enicostemma hyssopifolium

Pharmaceutical Biology

Volumn 49, Issue 4, 2011, Pages 383-391

  Patel, M B ^a   Mishra, S H ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

C glycosyl flavonoid; Enicostemma hyssopifolium; insulin releasing; insulin like

Indexed keywords

ANTIDIABETIC AGENT; ENICOSTEMMA HYSSOPIFOLIUM EXTRACT; FLAVONOID GLYCOSIDE; GLUCOSE; METHANOL; PLANT EXTRACT; STREPTOZOCIN; SWERTIAMARIN; SWERTISIN; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENICOSTEMMA HYSSOPIFOLIUM; ENZYME INHIBITION; FEMALE; FRACTIONATION; GENTIANACEAE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; LIVER CELL CARCINOMA; MALE; NONHUMAN; RAT;

ALDEHYDE REDUCTASE; ALPHA-GLUCOSIDASES; ANIMALS; APIGENIN; BLOOD GLUCOSE; CELL LINE, TUMOR; CELLS, CULTURED; CYTOPROTECTION; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GENTIANACEAE; GLUCONEOGENESIS; HYPOGLYCEMIC AGENTS; INSULIN; IRIDOID GLUCOSIDES; MALE; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PYRONES; RATS; RATS, WISTAR;

GENTIANACEAE; RATTUS;

EID: 79953102035     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2010.517759     Document Type: Article

References (44)

1. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. (2002). Antidiabetic efects of Panax ginseng berry extract and the identifcation of an efective component. Diabetes, 51, 1851-1858. (Pubitemid 34564298)
2. Babu PS, Stanely Mainzen Prince P. (2004). Antihyperglycaemic and antioxidant efect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. J Pharm Pharmacol, 56, 1435-1442. (Pubitemid 39472073)
3. Baynes JW. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes, 40, 405-412.
4. Chaudhuri RK, Singh AK, Ghosal S. (1975). Chemical constituents of Gentianaceae. XVIII. Structure of enicofavine. Monoterpene alkaloid from Enecostimma hyssopifolium. Chemical Industry (London) 3, 127-128.
5. Dahlqvist A. (1964). Method for assay of intestinal disaccharidases. Anal Biochem, 7, 18-25.
6. Daniel M, Sabnis SD. (1978). Chemical systematics of family Gentianaceae. Curr Sci, 47, 109-111.
7. Desai PD, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN, Manmade AH, Mohamed PA, Nagle SK, Nayak RH, Saksena AK, Sathe SS, Vishwanathan N. (1966). Chemical investigation of some Indian plants: Part II. Indian J Chem, 4, 457-459.
8. Flatt PR, Lenzen S. (2004). Frontiers of Insulin Secretion and Pancreatic f-Cell Research. London: Smith-Gordon.
9. Ghosal S, Jaiswal DK. (1980). Chemical constituents of Gentianaceae XXVIII: Flavonoids of Enicostemma hyssopifolium (Willd.) Verd. J Pharm Sci, 69, 53-56. (Pubitemid 10136820)
10. Ghosal S, Singh AK, Sharma PV, Chaudhuri RK. (1974). Chemical constituents of Gentianaceae. IX. Natural occurrence of erythrocentaurin in Enicostemma hyssopifolium and Swertia lawii. J Pharm Sci, 63, 944-945.
11. Gopal R, Gnanamani A, Udayakumar R, Sadulla S. (2004). Enicostemma littorale Blume-A potential hypolipidemic plant. Natural Product Radiance, 3, 401-405.
12. Govindachari TR, Sathe SS, Vishwanathan N. (1966). Gentianine, an artifact in Enicostemma littorale. Indian J Chem, 4, 201-202.
13. Gupta SS, Seth CB, Variyar MC. (1962). Experimental studies on pituitary-diabetes. I. Inhibitory efect of a Ayurvedic anti-diabetic remedies on anterior pituitary extract induced hyperglycaemia in albino rats. Indian J Med Res, 50, 73-81.
14. Halliwell B, Gutteridge JMC. (1989). Free Radicals in Biology and Medicine, second edition. Oxford: Oxford University Press.
15. Hayman S, Kinoshita JH. (1965). Isolation and properties of lens aldose reductase. J Biol Chem, 240, 877-882.
16. Jensen SR, Schripsema J. (2002). In: Struwe L, & Albert V eds. Gentianaceae-Systematics and Natural History. Cambridge: Cambridge University Press, 573-631.
17. Kang KA, Lee KH, Kim SY, Kim HS, Kim JS, Hyun JW. (2007). Cytoprotective efects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1. Biol Pharm Bull, 30, 852-858. (Pubitemid 46708625)
18. Kavimani S, Manisenthlkumar KT. (2000). Efect of methanolic extract of Enicostemma littorale on Dalton's ascitic lymphoma. J Ethnopharmacol, 71, 349-352. (Pubitemid 30440690)
19. Kinloch RA, Treherne JM, Furness LM, Hajimohamadreza I. (1999). Te pharmacology of apoptosis. Trends Pharmacol Sci, 20, 35-42.
20. Komatsu M, Tomimori T, Ito M. (1967). Studies on the constituents of Swertia japonica. I. On the structures of swertisin and isoswertisin. Chem Pharm Bull, 15, 263-269.
21. Lamba SS, Buch KY, Lewis HI, Lamba J. (2000). Phytochemicals as potential hypoglycemic agents. Stud Nat Prod Chem, 21, 457-496.
22. Lamela M, Cadavid I, Gato A, Calleja JM. (1985). Efects of Lythrum salicaria in normoglycemic rats. J Ethnopharmacol, 14, 83-91. (Pubitemid 16244316)
23. Latha M, Pari L, Sitasawad S, Bhonde R. (2004). Scoparia dulcis, a traditional antidiabetic plant, protects against streptozotocin induced oxidative stress and apoptosis in vitro and in vivo. J Biochem Mol Toxicol, 18, 261-272. (Pubitemid 39463519)
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem, 193, 265-275.
25. Lukic ML, Stosic-Grujicic S, Shahin A. (1998). Efector mechanisms in low-dose streptozotocin-induced diabetes. Dev Immunol, 6, 119-128. (Pubitemid 28409872)
26. Maroo J, Vasu VT, Aalinkeel R, Gupta S. (2002). Glucose lowering efect of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action. J Ethnopharmacol, 81, 317-320. (Pubitemid 34786315)
27. Murali B, Upadhyaya UM, Goyal RK. (2002). Efect of chronic treatment with Enicostemma littorale in non-insulin-dependent diabetic (NIDDM) rats. J Ethnopharmacol, 81, 199-204. (Pubitemid 34628502)
28. Rai J, Takar KA. (1966). Chemical investigation of Enicostemma littorale Blume. Curr Sci, 35, 148-149.
29. Retnam KR, DeBritt AJ. (1988). Preliminary phytochemical screening of three medicinal plants of tirunelveli hills. J Econ Texas Botany, 22, 677-681.
30. Sadique J, Chandra T, Tenmozhi V, Elango V (1987). Te anti-infammatory activity of Enicostemma littorale and Mollugo cerviana. Biochem Med Metab Biol, 37, 167-176. (Pubitemid 17073817)
31. Sarkar K, Sil PC (2006). A 43 kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes. Toxicol in Vitro, 20, 634-640. (Pubitemid 43833268)
32. Schmezer P, Eckert C, Liegibel UM. (1994). Tissue-specifc induction of mutations by streptozotocin in vivo. Mutat Res, 307, 495-499. (Pubitemid 24170563)
33. Shibano M, Kakutani K, Taniguchi M, Yasuda M, Baba K. (2008). Antioxidant constituents in the dayfower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity. J Nat Med, 62, 349-353.
34. Shim YJ, Doo HK, Ahn SY, Kim YS, Seong JK, Park IS, Min BH. (2003). Inhibitory efect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose. J Ethnopharmacol, 85, 283-287.
35. Spinas GA. (1999). Te dual role of nitric oxide in islet beta-cells. News Physiol Sci, 14, 49-54.
36. Srinivasan M, Padmanabhan M, Prince PS. (2005). Efect of aqueous Enicostemma littorale Blume extract on key carbohydrate metabolic enzymes, lipid peroxides and antioxidants in alloxan-induced diabetic rats. J Pharm Pharmacol, 57, 497-503. (Pubitemid 40515872)
37. Tarasov A, Dusonchet J, Ashcroft F. (2004). Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux. Diabetes, 53 Suppl 3, S113-S122. (Pubitemid 39564532)
38. Upadhyay UM, Goyal RK. (2004). Efcacy of Enicostemma littorale in Type 2 diabetic patients. Phytother Res, 18, 233-235. (Pubitemid 38568751)
39. Vasu VT, Ashwinikumar C, Maroo J, Gupta S, Gupta S. (2003). Antidiabetic efect of Enicostemma littorale Blume aqueous extract in newly diagnosed non-insulin-dependent diabetes mellitus patients (NIDDM): A preliminary investigation. Orient Pharm Exper Med, 3, 84-89.
40. Vasu VT, Modi H, Taikoottathil JV, Gupta S. (2005). Hypolipidaemic and antioxidant efect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats. J Ethnopharmacol, 101, 277-282. (Pubitemid 41265633)
41. Vijayvargia R, Kumar M, Gupta S. (2000). Hypoglycemic efect of aqueous extract of Enicostemma littorale Blume (chhota chirayata) on alloxan induced diabetes mellitus in rats. Indian J Exp Biol, 38, 781-784.
42. Vyas DS, Sharma VN, Sharma HK, Khanna NK. (1979). Preliminary study of antidiabetic properties of Aegle marmelos and Enicostemma littorale. J Res Indian Med, 14, 2-4.
43. Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. (2002). Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem, 277, 34933-34940.
44. Wiederkehr A, Wollheim CB. (2006). Minireview: implication of mitochondria in insulin secretion and action. Endocrinology, 147, 2643-2649. (Pubitemid 43764598)