Infertility and pregnancy in women with polycystic ovary syndrome

Minerva Endocrinologica

Volumn 35, Issue 4, 2010, Pages 211-225

  Nader, S ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Anovulation; Follicle stimulating hormone; Hyperandrogenism; Insulin resistance; Obesity; Ovulation induction

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANASTROZOLE; AROMATASE INHIBITOR; CABERGOLINE; CHORIONIC GONADOTROPIN; CLOMIFENE CITRATE; DEXAMETHASONE; FOLLITROPIN; GLUCOCORTICOID; INSULIN SENSITIZING AGENT; LETROZOLE; METFORMIN; PIOGLITAZONE; PLACEBO; PROGESTERONE; ROSIGLITAZONE; TROGLITAZONE;

ABSENCE OF SIDE EFFECTS; BARIATRIC SURGERY; CLINICAL TRIAL (TOPIC); DIATHERMY; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; LAPAROSCOPY; LIFESTYLE MODIFICATION; MULTIPLE PREGNANCY; OUTCOME ASSESSMENT; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY; REVIEW; SIDE EFFECT; WEIGHT GAIN;

CLOMIPHENE; DIAGNOSIS, DIFFERENTIAL; DRUG THERAPY, COMBINATION; FEMALE; FERTILITY AGENTS, FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; HUMANS; HYPERANDROGENISM; INFERTILITY, FEMALE; INSULIN ANTAGONISTS; INSULIN RESISTANCE; OVULATION; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PREGNANCY OUTCOME;

EID: 79953080006     PISSN: 03911977     EISSN: 18271634     Source Type: Journal    
DOI: None     Document Type: Review

References (89)

1. Diamanti-Kandarakis E, Kouli C, Bergiele A, Filandra FA, Tsianateli TC, Spina GG et al. A survey of polycystic ovary syndrome in the Greek island of Lesbos: Hormonal and metabolic profiles. J Clin Endocrinol Metab 1999;84:4006-11. (Pubitemid 30644187)
2. Ehrmann DA Polycystic ovary syndrome. N Engl J Med 2005;352:1223-36.
3. de Ugarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil Steril 2005;83:1454-60. (Pubitemid 40615820)
4. Rotterdam ESHRE/ASRM-sponsored polycystic ovary syndrome consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
5. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W et al. The Androgen Excess and PCOS Society Criteria for the polycystic ovary syndrome: The complete task force report. Fertil Steril 2009;91:456-88.
6. Nader S. Adrenarche and polycystic ovary syndrome: A tale of two hypotheses. J Pediatr Adolesc Gynecol 2007;20:353-60. (Pubitemid 350235976)
7. Blank SK, McCartney CR, Marshall JC. The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome. Hum Reprod Update 2006;12:351-61. (Pubitemid 43923410)
8. Strauss JF, Williams CJ. The ovarian life cycle. In: Strauss JF, Barbieri RL, editors. Yen and Jaffe's Reproductive Endocrinology. Philadelphia, PA: Saunders Elsevier; 2009. p. 155-90.
9. Messinis IE. Ovarian feedback, mechanism of action and possible clinical implications. Hum Reprod Update 2006;12:557-71.
10. Franks S. Anovulation in polycystic ovary syndrome. In: Diamanti-Kandarakis E, Nestler JE, Panidis D, Pasquali R, editors. Insulin resistance and polycystic ovary syndrome: pathogenesis, evaluation and treatment. Totowa: Humana Press; 2007. Ch. 22. p. 299-304.
11. Stubbs SA, Stark J, Dilworth SM, Franks S, Hardy K. Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division J Clin Endocrinol Metab 2007;92:4418-26.
12. Webber LJ, Stubbs S, Stark J, Trew GH, Margara R, Hardy K et al. Formation and early development of follicles in the polycystic ovary syndrome. Lancet 2003;362:1017-21. (Pubitemid 37186878)
13. Somunkiran A, Yavuz T, Yucel O, Ozdemir I. Antimullerian hormone levels during hormone contraception in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2007;134:196-201. (Pubitemid 47451601)
14. Pellatt L, Rice S, Mason H. Anti-mullerian hormone and polycystic ovary syndrome. A mountain too high. Reproduction 2010;139:825-33.
15. Catteau-Jonard S, Pigny P, Reyss A-C, Decanter S, Poncelet E Dewailly D. Changes in serum anti-mullerian hormone "level during low-dose recombinant FSH treatment for anovulation in polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:4138-43.
16. Devroey P, Fauser BCJM, Diedrick K on behalf of the Evian Annual Reproduction (EVAR) Workshop group 2008. Hum Reprod Update doi:10.1093/humupd/ dmp012.
17. WHO World Health Organization Laboratory Manual for the examination and processing of human semen. Geneva: World Health Organization; 2010.
18. Kettel LM, Roseff SJ, Berga S, Mortola JF, Yen SSC. Hypothalamic- pituitary-ovarian response to clomiphene citrate in women with polycystic ovary syndrome. Fertil Steril 1993;59:532-8. (Pubitemid 23086308)
19. Imani B, Eijkemans MC, Te Velde ER, Habea JDF, Fauser BCJM. Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab 1998;83:2361-5. (Pubitemid 28503028)
20. Santbrink RJ, Fauser BC. Ovulation induction in normogonadotropic anovulation (PCOS). Best Prac Res Clin Endocrinol Metab 2006;20:261-70. (Pubitemid 43842925)
21. Imani B, Eijkmans MJC, te Velde ER, Halbberna JDF, Fauser BCJM. A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligo amenorrheic infertility. Fertil Steril 2002;77:91-7.
22. Overbeck A, Lambalk CB. Pharmacogenomics of ovulation induction: facilitating decisions on who, when, how to treat. Pharmacogenomics 2009;10:1377-9.
23. Palomba S, Russo T, Orio Jr F, Falbo A, Manguso F, Sammartino A et al. Uterine effects of clomiphene citrate in women with polycystic ovary syndrome: a prospective controlled study. Hum Reprod 2006;21:2823-9. (Pubitemid 44566993)
24. White DM, Poison DW, Kiddy, Sagle P, Watson H, Gilling-Smith G et al. Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. J Clin Endocrinol Metab 1996;81:3821-4. (Pubitemid 26380380)
25. Delbaere A, Smits G, Olatunbosun O, Pierson R, Vassart G, Costagliola S. New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome? Hum Reprod 2004;19:486-9.
26. Smits G, Olatunbosun O, Delbaere A, Pierson R, Vassart G, Costagliola S. Ovarian hyperstimulation syndrome due to a mutation in the FSH receptor. New Engl J Med 2003;349:760-6. (Pubitemid 37010780)
27. Tang T, Balen AH. A woman with polycystic ovary syndrome treated for infertility by in vitro fertilization. Nat Rev Endocrinol 2009;5:462-5.
28. Pellicer A, Albert C, Mercader A, Bonilla-Musoles F, Remohi J, Simon C. The pathogenesis of ovarian hyperstimulation syndrome: in vivo studies investigating the role of interleukin-1 beta, interleukin 6 and vascular endothelial growth factor. Fertil Steril 1999;71:482-9. (Pubitemid 29094125)
29. rd, Vlahos NF. The ovarian hyperstimulation syndrome Fertil Steril 2000;73:883-96.
30. Aboulghar MA, Mansour RT, Serour GI, Amin Y. Ultrasonographically guided vaginal aspiration of ascites in the treatment of severe ovarian hyperstimulation syndrome. Fertil Steril 1990;53:933-5. (Pubitemid 20180489)
31. Ulug U, Baliceci M, Erden HF, Shaler E, Ben-Shlomo I. The significance of coasting during ovarian stimulation for conception in assisted fertility cycles. Hum Reprod 2002;17:310-3. (Pubitemid 34168432)
32. Youssef MAFM, van Wely M, Hassan MA, Al-Inany HG, Mochtar M, Khattab S et al. Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis. Hum Reprod Update 2010;16:459-66.
33. Humaidan P, Quartardo J, Papnikolaou EG. Preventing ovarian hyperstimulation syndrome: guidance for the clinician. Fertil Steril '2010;94:389-400.
34. van Santbrink EJ, Ejkemans MJ, Macklon NS, Fauser BC. FSH response dose can be predicted in ovulation induction for normogonadotropic infertility. Eur J Endocrinol 2002;147:223-6.
35. Van Santbrink, Fauser BC. Urinary FSH for normogonadotropic clomiphene-resistant anovulatory infertility: prospective randomized comparison between low-dose step-up and step-down regimens. J Clin Endocrinol Metab 1997;82:3597-602.
36. Imani B, Eijkemans MJ, Faessen GH, Bouchard P, Guidice LC, Fauser BC. Prediction of the individual FSH threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increasing safety and efficiency. Fertil Steril 2002;77:83-90. (Pubitemid 34093897)
37. Fauser BCJM, Diedrich K, Devroey P on behalf of the Evian Annual Reproductive (EVAR) Workshop Group 2007. Predictors of ovarian response: progress towards individual treatment in ovulation induction and ovarian stimulation. Hum Reprod Update 2008;14:1-14.
38. Nugent D, Vanderkerchove P, Hughes E, Arnot M, Lilford R. Gonadotropin therapy for ovulation induction in subfertility associated with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2000;3: Art No. CD000410. DOI:10.1002/14651858.CD000410.
39. Lord JM, Flight IHK, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and metaanalysis. BMJ 2003;327:951-3.
40. Palomba S, Orio Jr F, Falbo A, Manguso F, Russo T, Cascella T et al. Prospective parallel randomized double-blind double dummy controlled clinical trial comparing clomiphene citrate and metformin as first line treatment for ovulation induction in non-obese anovulatory women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:4068-74. (Pubitemid 41058174)
41. Moll E, Bassuyt PM, Korevaar JC, Lambalk CB, van der Veen F. Effect of clomiphene citrate plus metformin and clomiphene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: a randomized double blind clinical trial. BMJ 2006;332:1485-8. (Pubitemid 44365283)
42. Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA et al. Clomiphene, metformin or both for infertility in the polycystic ovary syndrome. N Engl J Med 2007;356:551-66. (Pubitemid 46220816)
43. Zain MM, Jamaluddin R, Ibrahim A, Norman RJ. Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial. Fertil Steril 2009;91:514-21.
44. Johnson NP, Stewart AW, Falkiner J, Farquhar CM, Milsom S Singh VP et al. PCOSMIC: a multi-centre randomized trial in women with polycystic ovary syndrome evaluating metformin for infertility with clomiphene. Hum Reprod 2010;25:1675-83.
45. Palomba S, Pasquali R, Orio F, Nestler JE. Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis. Clin Endocrinol 2009;70:311-21.
46. Azziz R, Ehrmann D, Legro RS, Whitcomb RW, Hanley R, Gmerek-Feresgetian A. PCOS/Troglitazone study group. Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double-blind placebo controlled trial. J Clin Endocrinol Metab 2006;86:1626-32.
47. Sepilian V, Nagamani M. Effects of rosiglitazone in obese women with polycystic ovary syndrome and severe insulin resistance. J Clin Endocrinol Metab 2005;90:60-5. (Pubitemid 40116634)
48. Brettenthaler N, de Geyter C, Huber PR, Keller U. Effect of insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism and ovulatory function in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89:3835-40. (Pubitemid 39071481)
49. Rouzi AA, Ardawi MSM. A randomized controlled trial of the efficacy of rosiglitazone and clomiphene citrate versus metformin and clomiphene citrate in women with clomiphene citrate-resistant polycystic ovary syndrome. Fertil Steril 2006;85:428-35.
50. Roy KK, Barvah J, Sharma A, Sharma JB, Kumar S, Kachava G et al. A prospective randomized trial comparing the clinical and endocrinological outcome with rosiglitazone versus laparoscopic ovarian drilling in patients with polycystic ovary disease resistant to ovulation induction with clomiphene citrate. Arch Gynecol Obstet DOI;10.1007/S00404-009-1305-8.
51. Haddad GF, Jodicke C, Thoms MA, Williams DB, Aubuchon M. Case series of rosiglitazone used during the first trimester of pregnancy. Reprod Toxicol 2008;26:183-4.
52. Casper RF, Mitwally MF, Review: Aromatase inhibitors for ovulation induction. J Clin Endocrinol Metab 2006;91:760-71. (Pubitemid 43361917)
53. Mitwally M, Casper RF. Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril 2001;75:305-9. (Pubitemid 32112106)
54. Badawy A, Aal IB, Abulatta M. Clomiphene citrate or anastrazole for ovulation induction in women with polycystic ovary syndrome? A prospective controlled trial. Fertil Steril 2009;92:860-3.
55. Tulandi T, Martin J, Al-Fadhli R, Kabli N, Forman R, Hitkari J et al. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil Steril 2006;85:1761-5. (Pubitemid 43816444)
56. Zeinalzadeh M, Basirat Z, Esmailpour M. Efficacy of Letrozole in ovulation induction compared to that of clomiphene citrate in patients with polycystic ovary syndrome. J Reprod Med 2010;5536-40.
57. Lobo RA, Paul W, March CM, Granger L, Kletzky OA. Clomiphene and dexamethasone in women unresponsive to clomiphene alone. Obstet Gynecol 1982;60:497-501. (Pubitemid 12018881)
58. Dale DG, Walters CA, Soto-Albors CE, Tohan N, Riddick DH. A randomized study of dexamethasone in ovulation induction with clomiphene citrate. Fertil Steril 1984;41:844-8.
59. Elnashar A, Abdelmageed E, Fayed M, Sharaf M. Clomiphene citrate and dexamethasone in treatment of clomiphene citrate-resistant polycystic ovary syndrome : a prospective placebo-controlled study. Hum Reprod 2006;21:1805-8. (Pubitemid 44028254)
60. Palomba S, Zollo F, Diamanti-Kandarakis E, Orio FJr. Surgery and laser diathermy. In: Diamanti-Kandarakis E, Nestler JE, Panidis D, Pasquali R, editors. Insulin resistance and polycystic ovary syndrome: Pathogenesis, evaluation and treatment. Totowa: Humana Press; 2007. Ch. 33. p. 461-77.
61. Greenblatt E, Casper RF. Endocrine changes after laparoscopic ovarian cautery in polycystic ovary syndrome. Am J Obstet Gynecol 1987;156:279-85. (Pubitemid 17020475)
62. Naether OGJ, Baukloh V, Fischer R, Kowalczyk T. Long-term follow-up in 206 infertility patients with polycystic ovary syndrome after laparoscopic electrocautery of the ovarian surface. Hum Reprod 1994;9:2342-9.
63. Farquhar C, Lilford RJ, Marjoribanks J, Vandekerckhove P. Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome Cochrane Database Syst Rev 2007;20(3):CD001122.
64. Palomba S, Orio Jr F, Nardo LG, Falbo A, Russo T, Corea D et al. Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrateresistant women with polycystic ovary syndrome: A prospective parallel randomized double-blind placebo-controlled trial. J Clin Endocrinol Metab 2004;89:4801-9.
65. Palomba S, Falbo A, Battista L, Russo T, Venturella R, Tolino A et al. Laparoscopic ovarian diathermy versus clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: A randomized controlled trial. Am J Obstet Gynecol 2010;202:577. e1-8.
66. Hamed D. Hasan AF, Ahmed OB, Ahmed MA. Metformin versus laparoscopic ovarian drilling in clomiphene-and-insulin-resistant women with polycystic ovary syndrome. Int J Gynaecol Obstet 2010;108:143-7.
67. Mercorio F, Mercorio A, DiSpiezio Sardo A, Barba GV, Pellicano M, Nappi C. Evaluation of ovarian adhesion formation after laparoscopic ovarian drilling by second-look mini-laparoscopy. Fertil Steril 2008;89:1229-33.
68. Api M. Is ovarian reserve diminished after laparoscop- ic ovarian drilling? Gynecol Endocrinol 2009;25:159-65.
69. Kiddy DS, Hamilton-Fairley D, Bush A, Short F, Anyaoku V, Reed MJ et al. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin Endocrinol 1992;36:105-11.
70. Huber-Buchholz MM, Care DG, Norman RJ. Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and LH. J Clin Endocrinol Metab 1999;84:1470-4. (Pubitemid 30644417)
71. Metwally M, Amer S, Li TC, Ledger WL. An RCT of metformin versus orlistat for management of obese anovulation women. Hum Reprod 2009;24:966-75.
72. Escobar-Morreale HF, Botella-Carretero JI, Alvarez-Blasco F, Sancho J, San Millan JL. The polycystic ovary syndrome association with morbid obesity may resolve after weight loss induced by bariatric surgery. J Clin Endocrinol Metab 2005;90:6364-9. (Pubitemid 41759284)
73. Eid GM, Cottam DR, Velcu LM, Mattar SG, Korytkowski MT, Gosman G et al. Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass Surg Obes Relat Dis 2005;1:77-80.
74. The Thessaloniki ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Thessaloniki 54603 Greece Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod 2008;23:462-77.
75. Palumbo S, Falbo A, Orio F, Tolino A, Zullo F. Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome. Fertil Steril 2009;91:2557-67.
76. Rausch ME, Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP et al. Predictors of pregnancy in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2009;94:3458-66.
77. Nader S. Live birth prediction in polycystic ovary syndrome. Nat Rev Endocrinol 2010;6:6445.
78. Eisenhaart S, Schwarzmann N, Henschel V, Germeyer A, vonWolff M, Hamann A et al. Early effects of metformin in women with polycystic ovary syndrome: A prospective randomized double-blind placebo-controlled trial. J Clin Endocrinol Metab 2006;91:946-52.
79. Beydoun HA, Stadtmauer L, Zhao Y, Russell H, Matson DO, Oehringer S. Impact of polycystic ovary syndrome or selected indicators of in vitro fertilization and intracytoplasmic sperm injection treatment success: J Womens Health 2009;18:717-23.
80. Tso LO, Costello MF, Albuquerque LE, Andriolo RB, Freitas V. Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome. Cochran Database Syst Rev 2009;15:CD006105.
81. Qublan HS, Al-Khaderei S, Abu-Salem N, Al-Zpoon A, Al-Khateeb M, Al-Ibrahim N et al. Metformin in the treatment of clomiphene-citrate resistant women with polycystic ovary syndrome undergoing in vitro fertilization treatment: A randomized controlled trial. J Obstet Gynaecol 2009;29:651-5.
82. Lainas TG, Sfontovris IA, Zorzovilis JZ, Petsas GK, Lainas GT, Alexopoulou E et al. Flexible GnRH antagonist protocol versus agonist long protocol in patients with polycystic ovary syndrome treated for IVF: A prospective randomized controlled trial (RCT). Hum Reprod 2010;25:683-9.
83. Barbieri RL Editorial: Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: The winner is ... J Clin Endocrinol Metab 2007;92:3399-401.
84. Boomsma CM, Eijkemans MJ, Hughes EG, Visser GH, Fauser BC, Macklon NS. A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Hum Reprod Update 2006;12:673-83. (Pubitemid 44605508)
85. Altieri P, Gambineri A, Prontera O, Cionci G, Franchira M, Pasquali R. Maternal polycystic ovary syndrome may be associated with adverse pregnancy outcomes. Eur J Obstet Reprod Biol 2010;149:31-6.
86. Hirschberg AL. Polycystic ovary syndrome obesity and reproductive implications. Women's Health 2009;5:529-542.
87. Hoeger KM, KochmanL, Wixom N, Craig K, Miller RK, Guzich DS. A randomized 48 week placebo controlled trial of intensive lifestyle modifications and/ or metformin therapy in overweight polycystic ovary syndrome: A pilot study. Fertil Steril 2004;82:421-9. (Pubitemid 39092044)
88. Vansky F, Salvesen KA, Heinstad R, Fougner KJ, Romundstad P, Carlesen PM. Metformin reduces pregnancy complications without affecting androgen levels in pregnancy polycystic ovary syndrome women: results of a randomized study. Hum Reprod 2004;19:1734-40. (Pubitemid 39144614)
89. Gilbert C, Valois M, Koren G. Pregnancy outcome after first trimester exposure to metformin: a meta analysis. Fertil Steril 2006;86:658-63.