What is the indication for sorafenib in hepatocellular carcinoma? A clinical challenge

Oncology

Volumn 25, Issue 3, 2011, Pages

  Kim, Richard ^a   Byrne, Michael T ^b   Tan, Ann ^c   Aucejo, Federico ^b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; DOXORUBICIN; PLACEBO; SORAFENIB; YTTRIUM 90;

ADVANCED CANCER; CANCER ADJUVANT THERAPY; CANCER RECURRENCE; CHEMOEMBOLIZATION; COLORECTAL CANCER; DRUG EFFICACY; DRUG INDICATION; DRUG RESPONSE; DRUG SAFETY; HEPATITIS B; HUMAN; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TOXICITY; LIVER TRANSPLANTATION; LOCAL THERAPY; OVERALL SURVIVAL; REVIEW; SIDE EFFECT; TREATMENT OUTCOME; VIRUS REACTIVATION;

EID: 79953076658     PISSN: 08909091     EISSN: 08909091     Source Type: Journal    
DOI: None     Document Type: Review

References (59)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer Statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
2. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557-76. (Pubitemid 46890874)
3. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693-9. (Pubitemid 26079803)
4. Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology. 1999;30:1434-40.
5. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet. 2003;362:1907-17. (Pubitemid 37518510)
6. El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology. 2004;127(5 Suppl 1):S27-S34. (Pubitemid 39423367)
7. Thomas MB, Zhu AX. Hepatocellular carcinoma: the need for progress. J Clin Oncol. 2005;23:2892-9. (Pubitemid 46224106)
8. Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-90.
9. Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-109. (Pubitemid 39331023)
10. Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25-34.
11. Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24:4293-300. (Pubitemid 46630787)
12. Abou-Alfa GK, Amadori D, Santoro A, et al. Is sorafenib (S) safe and effective in patients (pts) with hepatocellular carcinoma (HCC) and Child-Pugh B (CPB) cirrhosis? (Abstract 4518) J Clin Oncol. 2008(May 20 suppl)
13. Pinter M, Sieghart W, Graziadei I, et al. Sorafenib in unresectable hepatocellular carcinoma from mild to advanced stage liver cirrhosis. Oncologist. 2009;14:70-6.
14. Lee S, Kang Y, Chang H, et al. Sorafenib in patients with advanced hepatocellular carcinoma: experience in a single institute (abstract 256). Presented at the 2009 Gastrointestinal Cancers Symposium, San Francisco, CA, Jan 15-17, 2009.
15. Shim JH, Park JW, Choi JI, et al. Practical efficacy of sorafenib monotherapy for advanced hepatocellular carcinoma patients in a hepatitis B virus-endemic area. J Cancer Res Clin Oncol. 2009;135:617-25.
16. Furuse J, Ishii H, Nakachi K, et al. Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma. Cancer Sci. 2008;99:159-65. (Pubitemid 350239045)
17. Yau T, Chan P, Ng KK, et al. Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response. Cancer. 2009;115:428-36.
18. Sera T, Hiasa Y, Michitaka K, et al. Anti-HBs-positive liver failure due to hepatitis B virus reactivation induced by rituximab. Intern Med. 2006;45:721-4. (Pubitemid 44027603)
19. Ikeda K, Shiga Y, Takahashi A, et al. Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatment. Leuk Lymphoma. 2006;47:155-7. (Pubitemid 43101740)
20. DAmico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol. 2006;44:217-31. (Pubitemid 41772537)
21. Lencioni R, Marrero J, Venook A, et al. Design and rationale for the non-interventional Global Investigation of Therapeutic Decisions in Hepatocellular Carcinoma and Of its Treatment with Sorafenib (GIDEON) study. Int J Clin Pract. 2010;64:1034-41.
22. Wörns MA, Weinmann A, Pfingst K, et al. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis. J Clin Gastroenterol. 2009;43:489-95.
23. Xiao EH, Guo D, Bian DJ. Effect of preoperative transcatheter arterial chemoembolization on angiogenesis of hepatocellular carcinoma cells. World J Gastroenterol. 2009;15:4582-6.
24. Wang B, Xu H, Gao ZQ, et al. Increased expression of vascular endothelial growth factor in hepatocellular carcinoma after transcatheter arterial chemoembolization. Acta Radiol. 2008;49:523-9.
25. Lo CM, Ngan H, Tso WK, et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 2002;35:1164-71. (Pubitemid 34454013)
26. Marelli L, Stigliano R, Triantos C, et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol. 2007;30:6-25. (Pubitemid 44900485)
27. Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology. 2003;37:429-42. (Pubitemid 36152543)
28. Lammer J, Malagari K, Vogl T, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc Intervent Radiol. 2010;33:41-52.
29. Kulik LM, Carr BI, Mulcahy MF, et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology. 2008;47:71-81. (Pubitemid 351171043)
30. Salem R, Lewandowski RJ, Mulcahy MF, et al. Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: a comprehensive report of long-term outcomes. Gastroenterology. 2010;138:52-64.
31. Okita K, Imanaka N, Chida N, et al. Phase III study of sorafenib in patients in Japan and Korea with advanced hepatocellular carcinoma (HCC) treated after transarterial chemoembolization (TACE) (Abstract LBA 128). Presented at the 2010 ASCO Gastrointestinal Cancers Symposium, Orlando, FL, Jan 22-24, 2010.
32. Chow PK, Poon D, Win KM, et al. Multicenter phase II study of SIR-sphere plus sorafenib as first-line treatment in patients with nonresectable hepatocellular carcinoma: the Asia-Pacific Hepatocellular Carcinoma Trials Group Protocol 05 (AHCC05) (Abstract 4072). J Clin Oncol. 2010;28:15s.
33. Reyes DK, Azad NS, Koteish A, et al. Phase II trial of sorafenib combined with doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) for patients with unresectable hepatocellular carcinoma (HCC): Interim safety and efficacy analysis (Abstract 254). Presented at the 2010 ASCO Gastrointestinal Cancers Symposium, Orlando, FL, Jan 22-24, 2010.
34. A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. Groupe dEtude et de Traitement du Carcinome Hepatocellulaire. N Engl J Med. 1995; 332:1256-61.
35. Almhanna K, Kalmadi S, Pelley R, Kim R. Neoadjuvant therapy for hepatocellular carcinoma: is there an optimal approach? Oncology (Williston Park). 2007;21:1116-22.
36. Miller AA, Murry DJ, Owzar K, et al. Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. J Clin Oncol. 2009;27:1800-5.
37. Vitale A, Volk ML, Pastorelli D, et al. Use of sorafenib in patients with hepatocellular carcinoma before liver transplantation: a cost-benefit analysis while awaiting data on sorafenib safety. Hepatology. 2010;51:165-73.
38. Kesmodel SB, Ellis LM, Lin E, et al. Preoperative bevacizumab does not significantly increase postoperative complication rates in patients undergoing hepatic surgery for colorectal cancer liver metastases. J Clin Oncol. 2008;26:5254-60.
39. Karoui M, Penna C, Amin-Hashem M, et al. Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann Surg. 2006;243:1-7. (Pubitemid 43054046)
40. Ellis LM, Curley SA, Grothey A. Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab. J Clin Oncol. 2005;23:4853-5. (Pubitemid 46223989)
41. Cowey CL, Amin C, Pruthi RS, et al. Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma. J Clin Oncol. 2010;28:1502-7.
42. Vagefi PA, Hirose R. Downstaging of hepatocellular carcinoma prior to liver transplant: is there a role for adjuvant sorafenib in locoregional therapy? J Gastrointest Cancer. 2010;41:217-20.
43. Kim R, Menon N, Aucejo F. Safe use of sorafenib in a patient undergoing salvage liver transplantation for recurrent hepatocellular carcinoma after hepatic resection. Med Oncol. 2010; Jul 16. [Epub ahead of print]
44. Molmenti EP, Klintmalm GB. Liver transplantation in association with hepatocellular carcinoma: an update of the international tumor registry. Liver Transpl. 2002;8:736-48. (Pubitemid 35012281)
45. Feun LG, Levi D, Moon J, et al. Sorafenib in hepatocellular carcinoma (HCC) patients after liver transplantation (Abstract e15579).. J Clin Oncol. 2009;27.
46. Yoon DH, Ryoo BY, Ryu MH, et al. Sorafenib for recurrent hepatocellular carcinoma after liver transplantation. Jpn J Clin Oncol. 2010;40:768-73.
47. Kim R, El-Gazzaz G, Tan A, et alet al. Safety and feasibility of using sorafenib in recurrent hepatocellular carcinoma after orthotopic liver transplantation. Oncology (Williston Park). 2010. 25:XXXX-XXXX.
48. Del Prete S, Montella L, Addeo R, et al. Sorafenib plus long-acting octreotide in advanced hepatocellular carcinoma. Preliminary results of a multicenter ongoing study (Abstract 15624). J Clin Oncol. 2008;26(15 May 20 Suppl).
49. Schuette K, Zimmermann L, Bornschein J, et al. Tolerability of sorafenib in the treatment of hepatocellular carcinoma (HCC) in patients with Child A and B liver cirrhosis (Abstract e15593). J Clin Oncol. 2009;27 Suppl)
50. Balsom SM, Li X, Trolli E, et al. A single-institute experience with sorafenib in untreated and previously treated patients with advanced hepatocellular carcinoma. Oncology. 2010;78:210-2.
51. Ozenne V, Paradis V, Pernot S, et al. Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib. Eur J Gastroenterol Hepatol. 2010;22:1106-10.
52. Xu L, Li P, Lin XJ, et al. Clinical observation of sorafenib monotherapy in Chinese patients with advanced hepatocellular carcinoma. Zhonghua Zhong Liu Za Zhi. 2009;31:58-61.
53. Sinakos E, Dedes I, Papalavrentios L, et al. Safety of transarterial chemoembolization plus sorafenib combination treatment in unresectable hepatocellular carcinoma. Scand J Gastroenterol. 2010;45:511-2.
54. Duan F, Wang MQ, Liu FY, et al. Clinical observation of the treatment with combination of transcatheter arterial chemoembolization and sorafenib for hepatocellular carcinoma with lung metastasis. Zhonghua Zhong Liu Za Zhi. 2009;31:716-8.
55. Cabrera R, George T, Soldevila-Pico C, et al. Safety of sorafenib alone or in combination with locoregional therapy in patients with advanced hepatocellular carcinoma (HCC) and decompensated cirrhosis (Abstract 147). Presented at the 2008 ASCO Gastrointestinal Cancers Symposium, Orlando, FL, Jan 25-27, 2008.
56. Martin II RC, Keck G, Robbins K, et al. Evaluation of sorafenib in combination with doxorubicin-loaded DC bead as a combination treatment option for HCC (Abstract 216). Presented at the 2010 ASCO Gastrointestinal Cancers Symposium, Orlando, FL, Jan 22-24, 2010.
57. Chung Y, Kim B, Chen C, et al. Study in Asia of the combination of transcatheter arterial chemoembolization (TACE) with sorafenib in patients with hepatocellular carcinoma (HCC) trial (START): second interim safety and efficacy analysis (Abstract 4026). J Clin Oncol. 2010;28(15 May 20 Suppl).
58. Valdivieso A, Bustamante J, Gastaca M, et al. Management of hepatocellular carcinoma recurrence after liver transplantation. Transplant Proc. 2010;42:660-2.
59. Yeganeh M, Finn RS, Saab S. Apparent remission of a solitary metastatic pulmonary lesion in a liver transplant recipient treated with sorafenib. Am J Transplant. 2009;9:2851-4.