Increased nitric oxide production in platelets from severe chronic renal failure patients

Canadian Journal of Physiology and Pharmacology

Volumn 89, Issue 2, 2011, Pages 97-102

  de ŚSiqueira, Mariana Alves ^a   Brunini, Tatiana M C ^a   Pereira, Natália Rodrigues ^a   Martins, Marcela Anjos ^a   Moss, Monique Bandeira ^a   Santos, Sérgio F ^a   Lugon, Jocemir R ^b   Mendes Ribeiro, Antônio C ^a,c  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c FEDERAL UNIVERSITY OF THE STATE OF RIO DE JANEIRO   (Brazil)

Author keywords

Cgmp; Chronic renal failure; Conservative treatment; L arginine; Nitric oxide; Nos activity; Nos expression; Platelets

Indexed keywords

ADENOSINE DIPHOSPHATE; ARGININE; CHOLESTEROL; COLLAGEN; CREATININE; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRINOGEN; GLUCOSE; HEMOGLOBIN; INDUCIBLE NITRIC OXIDE SYNTHASE; POTASSIUM; UREA;

ADULT; ARTICLE; BIOSYNTHESIS; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONSERVATIVE TREATMENT; CONTROLLED STUDY; CREATININE CLEARANCE; ENZYME ACTIVITY; FEMALE; FIBRINOGEN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERTENSION; INFLAMMATION; MALE; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; UREA BLOOD LEVEL;

ADENOSINE DIPHOSPHATE; ARGININE; BLOOD PLATELETS; CASE-CONTROL STUDIES; COLLAGEN; CYCLIC GMP; FEMALE; FIBRINOGEN; HUMANS; INFLAMMATION; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PLATELET AGGREGATION;

EID: 79953075790     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y10-111     Document Type: Article

References (42)

1. Abdel-Naeem, N.M., Kandell, N.F., El-Shamaa, A.A., Harba, T.M., and Abdel-Hady, A.A. 2005. Biocompatible dialysis membranes and oxidative stress in patients with end-stage renal disease on maintenance haemodialysis. J. Egypt. Soc. Parasitol. 35(3 Suppl): 1173-1197. PMID:16363293.
2. +L by surface potential, ouabain and thrombin in human platelets: effects of uremia. Nephron. Exp. Nephrol. 107(4): e132-e138. doi:10. 1159/000111040.
3. Ballow, A., Gader, A.M., Huraib, S., Al-Husaini, K., Mutwalli, A., and Al-Wakeel, J. 2005. Platelet surface receptor activation in patients with chronic renal failure on hemodialysis, peritoneal dialysis and those with successful kidney transplantation. Platelets, 16(1): 19-24. doi:10.1080/09537100412331272569. PMID: 15763892.
4. +L. Pflugers Arch. 445(5): 547-550. PMID:12634924.
5. Brunini, T.M., da Silva, C.D., Siqueira, M.A., Moss, M.B., Santos, S.F., and Mendes-Ribeiro, A.C. 2006a. Uremia, atherothrombo-sis and malnutrition: the role of L-arginine-nitric oxide pathway. Cardiovasc. Hematol. Disord. Drug Targets, 6(2): 133-140. PMID:16787198.
6. Brunini, T.M., Roberts, N.B., Yaqoob, M.M., Ellory, J.C., Mann, G.E., and Mendes Ribeiro, A.C. 2006b. Activation of L-arginine transport in undialysed chronic renal failure and continuous ambulatory peritoneal dialysis patients. Clin. Exp. Pharmacol. Phy-siol. 33(1-2): 114-118. doi:10.1111/j.1440-1681.2006.04333.x. PMID:16445709.
7. Brunini, T.M., Mendes-Ribeiro, A.C., Ellory, J.C., and Mann, G.E. 2007. Platelet nitric oxide synthesis in uremia and malnutrition: a role for L-arginine supplementation in vascular protection? Cardiovasc. Res. 73(2): 359-367. doi:10.1016/j.cardiores.2006. 09.019. PMID:17078937.
8. Caimi, G., Carollo, C., Montana, M., Vaccaro, F., and Lo Presti, R. 2009. Elastase, myeloperoxidase, nitric oxide metabolites and oxidative status in subjects with clinical stable chronic renal failure on conservative treatment. Clin. Hemorheol. Microcirc. 43(3): 253-258. PMID:19847059.
9. Campean, V., Neureiter, D., Varga, I., Runk, F., Reiman, A., Garlichs, C., et al. 2005. Atherosclerosis and vascular calcification in chronic renal failure. Kidney Blood Press. Res. 28(5-6): 280-289. doi:10.1159/000090182. PMID:16534222.
10. Closs, E.I., Simon, A., Vékony, N., and Rotmann, A. 2004. Plasma membrane transporters for arginine. J. Nutr. 134(10 Suppl): 2752S-2759S, discussion 2765S-2767S. PMID:15465780.
11. da Silva, C.D., Brunini, T.M., Reis, P.F., Moss, M.B., Santos, S.F., Roberts, N.B., et al. 2005. Effects of nutritional status on the L-arginine-nitric oxide pathway in platelets from hemodialysis patients. Kidney Int. 68(5): 2173-2179. doi:10.1111/j.1523-1755. 2005.00673.x. PMID:16221216.
12. De Vecchi, A.F., Bamonti, F., Novembrino, C., Ippolito, S., Guerra, L., Lonati, S., et al. 2009. Free and total plasma malon-dialdehyde in chronic renal insufficiency and in dialysis patients. Nephrol. Dial. Transplant. 24(8): 2524-2529. doi:10. 1093/ndt/gfp102. PMID:19264746.
13. El-Mesallamy, H.O., Abdel Hamid, S.G., and Gad, M.Z. 2008. Oxidative stress and asymmetric dimethylarginine are associated with cardiovascular complications in hemodialysis patients: improvements by L-arginine intake. Kidney Blood Press. Res. 31(3): 189-195. doi:10.1159/000135655. PMID:18511874.
14. El-Shahawy, M., Noureddin, M., Abdullah, H., Mack, W.J., and Calverley, D.C. 2007. Platelet FcγRIIA receptor surface expression is increased in patients with ESRD and is associated with atherosclerotic cardiovascular events. Am. J. Kidney Dis. 49(1): 127-134. doi:10.1053/j.ajkd.2006.09.022. PMID:17185153.
15. Featherston, W.R., Rogers, Q.R., and Freedland, R.A. 1973. Relative importance of kidney and liver in synthesis of arginine by the rat. Am. J. Physiol. 224(1): 127-129. PMID:4683290.
16. Fellah, H., Feki, M., Souissi, M., Ghorbel, H., Ben Abdallah, T., Massy, Z., et al. 2006. Oxidative stress in end stage renal disease: evidence and association with cardiovascular events in Tunisian patients.Tunis. Med. 84(11): 724-729. PMID:17294900.
17. Förstermann, U. 2010. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch. 459(6): 923-939. doi:10.1007/s00424-010-0808-2. PMID:20306272.
18. Gambaryan, S., Kobsar, A., Hartmann, S., Birschmann, I., Kuhlencordt, P.J., Müller-Esterl, W., et al. 2008. NO-synthase-/ NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity. J. Thromb. Haemost. 6(8): 1376-1384. doi:10.1111/j.1538-7836.2008.03014.x. PMID:18485089.
19. Goi, G., Massaccesi, L., Baquero Herrera, C.J., Musetti, C., Ciurlino, D., Cusi, D., and Bertoli, S. 2009. Oxidative stress in elderly chronic renal failure patients: effects of renal replacement therapies on cell membrane fluidity. J. Nephrol. 22(5): 630-636. PMID:19809996.
20. Guérin, A.P., Pannier, B., Marchais, S.J., and London, G.M. 2006. Cardiovascular disease in the dialysis population: prognostic significance of arterial disorders. Curr. Opin. Nephrol. Hypertens. 15(2): 105-110. doi:10.1097/01.mnh.0000203186.11772.21. PMID:16481874.
21. Landray, M.J., Wheeler, D.C., Lip, G.Y., Newman, D.J., Blann, A.D., McGlynn, F.J., et al. 2004. Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study. Am. J. Kidney Dis. 43(2): 244-253. doi:10.1053/j.ajkd. 2003.10.037. PMID:14750089.
22. Malaponte, G., Libra, M., Bevelacqua, Y., Merito, P., Fatuzzo, P., Rapisarda, F., et al. 2007. Inflammatory status in patients with chronic renal failure: the role of PTX3 and pro-inflammatory cy-tokines. Int. J. Mol. Med. 20(4): 471-481. PMID:17786277.
23. Malyszko, J., Malyszko, J.S., and Mysliwiec, M. 2001. Comparison of hemostatic disturbances between patients on CAPD and patients on hemodialysis. Perit. Dial. Int. 21(2): 158-165. PMID: 11330560.
24. Marjanovic, J.A., Stojanovic, A., Brovkovych, V.M., Skidgel, R.A., and Du, X. 2008. Signaling-mediated functional activation of in-ducible nitric-oxide synthase and its role in stimulating platelet activation. J. Biol. Chem. 283(43): 28827-28834. doi:10.1074/ jbc.M801646200. PMID:18753139.
25. Mehta, J.L., Chen, L.Y., Kone, B.C., Mehta, P., and Turner, P. 1995a. Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J. Lab. Clin. Med. 125(3): 370-377. PMID:7534807.
26. +L as the high-affinity transporter for L-arginine in human platelets: up-regulation of L-arginine influx in uraemia. Pflugers Arch. 438(4): 573-575. doi:10.1007/s004240051078. PMID:10519154.
27. Mendes Ribeiro, A.C., Brunini, T.M., Ellory, J.C., and Mann, G.E. 2001. Abnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure. Cardiovasc. Res. 49(4): 697-712. doi:10.1016/S0008-6363(00)00267-4. PMID: 11230969.
28. Mezzano, S., and Aros, C. 2005. Chronic kidney disease: classification, mechanisms of progression and strategies for renoprotec-tion. Rev. Med. Chil. 133(3): 338-348. PMID:15880190.
29. Mezzano, D., Tagle, R., Pais, E., Panes, O., Pérez, M., Downey, P., et al. 1997. Endothelial cell markers in chronic uremia: relationship with hemostatic defects and severity of renal failure. Thromb. Res. 88(6): 465-472. doi:10.1016/S0049-3848(97) 00280-6. PMID:9610957.
30. Mezzano, D., España, F., Panes, O., Medina, P., Pais, E., Marshall, G., et al. 2001a. Increased activation of protein C, but lower plasma levels of free, activated protein C in uraemic patients: relationship with systemic inflammation and haemostatic activation. Br. J. Haematol. 113(4): 905-910. doi:10.1046/j.1365-2141.2001.02848.x. PMID:11442482.
31. Mezzano, D., Pais, E.O., Aranda, E., Panes, O., Downey, P., Ortiz, M., et al. 2001b. Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia. Kidney Int. 60(5): 1844-1850. doi:10.1046/ j.1523-1755.2001.00998.x. PMID:11703602.
32. Moe, S.M., and Chen, N.X. 2004. Pathophysiology of vascular calcification in chronic kidney disease. Circ. Res. 95(6): 560-567. doi:10.1161/01.RES.0000141775.67189.98. PMID:15375022.
33. Moncada, S., and Higgs, E.A. 2006. The discovery of nitric oxide and its role in vascular biology. Br. J. Pharmacol. 147(S1 Suppl 1): S193-S201. doi:10.1038/sj.bjp.0706458. PMID:16402104.
34. Morris, S.M., Jr. 2006. Arginine: beyond protein. Am. J. Clin. Nutr. 83(2): 508S-512S. PMID:16470022.
35. Moss, M.B., Siqueira, M.A., Mann, G.E., Brunini, T.M., and Mendes-Ribeiro, A.C. 2010. Platelet aggregation in arterial hypertension: is there a nitric oxide-urea connection? Clin. Exp. Pharmacol. Physiol. 37(2): 167-172. doi:10.1111/j.1440-1681. 2009.05247.x. PMID:19566824.
36. Pawlak, K., Buraczewska-Buczko, A., Mysliwiec, M., and Pawlak, D. 2010. Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment. Am. J. Med. Sci. 339(1): 5-9. doi:10.1097/MAJ.0b013e3181b922a4. PMID: 19926968.
37. Ritchie, J.L., Crawford, V.L., McNulty, M., Alexander, H.D., and Stout, R.W. 2000. Effect of tourniquet pressure and intra-indivi-dual variability on plasma fibrinogen, platelet P-selectin and monocyte tissue factor. Clin. Lab. Haematol. 22(6): 369-372. doi:10.1046/j.1365-2257.2000.00337.x. PMID:11318805.
38. Rodrigues Pereira, N., Bandeira Moss, M., Assumpção, C.R., Cardoso, C.B., Mann, G.E., Brunini, T.M., and Mendes-Ribeiro, A.C. 2010. Oxidative stress, L-arginine-nitric oxide and arginase pathways in platelets from adolescents with anorexia nervosa. Blood Cells Mol. Dis. 44(3): 164-168. doi:10.1016/j.bcmd. 2009.12.003. PMID:20071203.
39. Salvati, F., and Liani, M. 2001. Role of platelet surface receptor abnormalities in the bleeding and thrombotic diathesis of uremic patients on hemodialysis and peritoneal dialysis. Int. J. Artif. Organs, 24(3): 131-135. PMID:11314805.
40. Schiffrin, E.L., Lipman, M.L., and Mann, J.F. 2007. Chronic kidney disease: effects on the cardiovascular system. Circulation, 116(1): 85-97. doi:10.1161/CIRCULATIONAHA.106.678342. PMID:17606856.
41. Vanholder, R., Van Laecke, S., and Glorieux, G. 2008. The middle-molecule hypothesis 30 years after: lost and rediscovered in the universe of uremic toxicity? J. Nephrol. 21(2): 146-160. PMID: 18446708.
42. Vignini, A., Nanetti, L., Moroni, C., Tanase, L., Bartolini, M., Luzzi, S., et al. 2007. Modifications of platelet from Alzheimer disease patients: a possible relation between membrane properties and NO metabolites. Neurobiol. Aging, 28(7): 987-994. doi:10.1016/j.neurobiolaging.2006.05.010. PMID:16815594.