ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma

American Journal of Surgical Pathology

Volumn 35, Issue 3, 2011, Pages 432-441

  Miettinen, Markku ^a   Wang, Zeng Feng ^a   Paetau, Anders ^b   Tan, Shyh Han ^c,d   Dobi, Albert ^c,d   Srivastava, Shiv ^c,d   Sesterhenn, Isabell ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

angiosarcoma; ERG; ETS family transcription factor; hemangioendothelioma; hemangioma; immunohistochemistry; prostate carcinoma

Indexed keywords

DIAGNOSTIC AGENT; ERG PROTEIN, HUMAN; MONOCLONAL ANTIBODY; TRANSACTIVATOR PROTEIN; TUMOR MARKER;

ADENOCARCINOMA; ARTICLE; CHEMISTRY; ENDOTHELIUM CELL; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; PROSTATE TUMOR; VASCULAR TUMOR;

ADENOCARCINOMA; ANTIBODIES, MONOCLONAL; ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROSTATIC NEOPLASMS; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL; VASCULAR NEOPLASMS;

EID: 79953059276     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318206b67b     Document Type: Article

References (33)

1. Baltzinger M, Mager-Heckel AM, Remy P. XI erg: Expression pattern and overexpression during development plead for a role in endothelial cell differentiation. Dev Dyn. 1999;216: 420-433.
2. Birdsey GM, Dryden NH, Amsellem V, et al. Transcription factor erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood. 2008;111:3498-3506.
3. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarco-mas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothe-lium. Am J Pathol. 1999;154:385-394. (Pubitemid 29094089)
4. De Young BR, Wick MR, Fitzgibbon JF, et al. CD31: an immunospecific marker for endothelial differentiation in human neoplasms. Appl Immunohistochem. 1993;1:97-100.
5. Folpe AL, Chand EM, Goldblum JR, et al. Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol. 2001;25:1061-1066. (Pubitemid 32685904)
6. Furusato B, Tan SH, Young D, et al. ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification. Prostate Cancer Prostatic Dis. 2010;13:228-237.
7. Fury MG, Antonescu CR, van Zee KJ, et al. A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer J. 2005;11:241-247. (Pubitemid 44698813)
8. Ginsberg JP, de Alava E, Ladanyi M, et al. EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. J Clin Oncol. 1999;17:1809-1814. (Pubitemid 29269251)
9. Gonzalez-Crussi F, Reyes-Mugica M. Cellular hemangiomas ("hemangio-endotheliomas") in infants. Light microscopic, immuno-histochemical, and ultrastructural observations. Am J Surg Pathol. 1991;15:769-778.
10. Hewett PW, Nishi K, Daft EL, et al. Selective expression of erg isoforms in human endothelial cells. Int J Biochem Cell Biol. 2001; 33:347-355. (Pubitemid 32324003)
11. Itakura E, Yamamoto H, Oda Y, et al. Detection and characteriza-tion of vascular endothelial growth factors and their receptors in a series of angiosarcomas. J Surg Oncol. 2008;97:74-81.
12. Kong XT, Ida K, Ichikawa H, et al. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood. 1997;90:1192-1199. (Pubitemid 27314156)
13. Kuzu I, Bicknell R, Harris AL, et al. Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours. J Clin Pathol. 1992;45:143-148.
14. Ladanyi M. The emerging molecular genetics of sarcoma transloca-tions. Diagn Mol Pathol. 1995;4:162-173.
15. Loughran SJ, Kruse EA, Hacking DF, et al. The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol. 2008;9:810-819. (Pubitemid 351859165)
16. Marcucci G, Baldus CD, Ruppert AS, et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a cancer and leukemia group B study. J Clin Oncol. 2008;23:9234-9242.
17. McKenney JK, Weiss SW, Folpe AL. CD31 expression in intratumoral macrophages: a potential diagnostic pitfall. Am J Surg Pathol. 2001;25:1167-1173. (Pubitemid 32777716)
18. Miettinen M, Fetsch JF. Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol. 2000;31:1062-1067.
19. Miettinen M, Lindenmayer AE, Chaubal A. Endothelial cell markers CD31, CD34, and BNH9 antibody to H-and Y-antigens-Evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand's factor. Mod Pathol. 1994;7:82-90.
20. Mohamed AA, Tan SH, Mikhalkevich N, et al. Ets family protein, Erg expression in developing and adult mouse tissues by a highly specific monoclonal antibody. J Cancer. 2010;1:197-208.
21. Park K, Tomlins SA, Mudaliar KM, et al. Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia. 2010;12:590-598.
22. Panagopoulos I, Lassen C, Isaksson M, et al. Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP, and FUS/ERG in myxoid liposarcoma and acutemyeloidleukemia. Oncogene. 1997;15:1357-1362. (Pubitemid 27429752)
23. Partanen TA, Alitalo K, Miettinen M. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. Cancer. 1999;86:2406-2412. (Pubitemid 30010384)
24. Pustztaszeri MP, Seelentag W, Bosman FT. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem. 2006;54:385-395.
25. Ramani P, Bradley NJ, Fletcher CDM. QBEND/10, a new monoclonal antibody to endothelium: assessment of its diagnostic utility in paraffin sections. Histopathology. 1990;17: 237-242. (Pubitemid 20275966)
26. Rossi S, Orvieto E, Furlanetto A, et al. Utility of the immunohis-tochemical detection of Fli-1 expression in round cell and vascular neoplasms using a monoclonal antibody. Mod Pathol. 2004;17:547-552. (Pubitemid 38868421)
27. Sato Y. Role of ETS family transcription factors in vascular development and angiogenesis. Cell Structure and Function. 2001;26:19-24. (Pubitemid 32421948)
28. Schacht V, Dadras SS, Johnson LA, et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glyco-protein in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005;166:913-921. (Pubitemid 40315647)
29. Simpson S, Woodworth CD, DiPaolo JA. Altered expression of Erg and Ets-2 transcription factors is associated with genetic changes at 21q22.2-22.3 in immortal and cervical carcinoma cell lines. Oncogene. 1997;14:2149-2157. (Pubitemid 27248226)
30. Sun S, Dobi A, Mohamed A, et al. TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene. 2008;27:5348-5353.
31. Traweek ST, Kandalaft P, Mehta P, et al. The human progenitor cell antigen (CD34) in vascular neoplasia. Am J Clin Pathol. 1991;96:25-31.
32. Van de Rijn M, Rouse RV. CD34-A review. Appl Immunohistochem. 1994;2:71-80.
33. Vlaeminck-Guillem V, Carrere S, Dewitte F, et al. The Ets family member Erg gene is expressed in mesodermal tissues and neural crests as fundamental steps in mouse embryogenesis. Mech Dev. 2000;91:331-335. (Pubitemid 30125933)