ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion

Oncogene

Volumn 30, Issue 12, 2011, Pages 1413-1421

  Yagi, R ^a   Tanaka, M ^a,b   Sasaki, K ^c   Kamata, R ^a   Nakanishi, Y ^a   Kanai, Y ^a   Sakai, R ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b AKITA UNIVERSITY   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

ARAP3; cell ECM adhesion; invasion; Rho GAP; scirrhous gastric carcinoma

Indexed keywords

ANKYRIN REPEAT AND PH DOMAIN 3; PROTEIN TYROSINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL ADHESION; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STOMACH CARCINOMA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA, SCIRRHOUS; CELL ADHESION; CELL LINE, TUMOR; GASTRIC MUCOSA; GTPASE-ACTIVATING PROTEINS; HUMANS; NEOPLASM INVASIVENESS; PERITONEUM; PROTEIN STRUCTURE, TERTIARY; SRC-FAMILY KINASES; STOMACH NEOPLASMS;

HOMO SAPIENS;

EID: 79953057231     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.522     Document Type: Article

References (24)

1. Brown MT, Cooper JA. (1996). Regulation, substrates and functions of src. Biochem Biophys Acta 1287: 121-149. (Pubitemid 26189191)
2. Carragher NO, Frame MC. (2004). Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol 14: 241-249. (Pubitemid 38591328)
3. Carramusa L, Ballestrem C, Zilberman Y, Bershadsky AD. (2007). Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions. J Cell Sci 120: 3870-3882. (Pubitemid 350187368)
4. Chen TJ, Gehler S, Shaw AE, Bamburg JR, Letourneau PC. (2006). Cdc42 participates in the regulation of ADF/cofilin and retinal growth cone filopodia by brain derived neurotrophic factor. J Neurobiol 66: 103-114. (Pubitemid 43100725)
5. Daniele T, Di Tullio G, Santoro M, Turacchio G, De Matteis MA. (2008). ARAP1 regulates EGF receptor trafficking and signalling. Traffic 9: 2221-2235.
6. Faix J, Grosse R. (2006). Staying in shape with formins. Dev Cell 10: 693-706. (Pubitemid 43779105)
7. Frame MC. (2002). Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta 1602: 114-130. (Pubitemid 34521791)
8. Huveneers S, Danen EH. (2009). Adhesion signaling-crosstalk between integrins, Src and Rho. J Cell Sci 122: 1059-1069.
9. I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H et al. (2004). ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. J Cell Sci 117: 6071-6084. (Pubitemid 40136469)
10. Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S. (1999). An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 5: 221-225. (Pubitemid 29068531)
11. Kim HS, Bae CD, Park J. (2010). Glutamate receptor-mediated phosphorylation of ezrin/radixin/moesin proteins is implicated in filopodial protrusion of primary cultured hippocampal neuronal cells. J Neurochem 113: 1565-1576.
12. Kowanetz K, Husnjak K, Holler D, Kowanetz M, Soubeyran P, Hirsch D et al. (2004). CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell 15: 3155-3166. (Pubitemid 38850113)
13. Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J et al. (2002). Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell 9: 95-108. (Pubitemid 34127774)
14. Krugmann S, Andrews S, Stephens L, Hawkins PT. (2006). ARAP3 is essential for formation of lamellipodia after growth factor stimulation. J Cell Sci 119: 425-432.
15. Krugmann S, Williams R, Stephens L, Hawkins PT. (2004). ARAP3 is a PI3K- and rap-regulated GAP for RhoA. Curr Biol 14: 1380-1384. (Pubitemid 39081641)
16. Matsuoka T, Hirakawa K, Chung YS, Yashiro M, Nishimura S, Sawada T et al. (1998). Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer. Clin Exp Metastasis 16: 381-388. (Pubitemid 28255533)
17. Nishimura S, Chung YS, Yashiro M, Inoue T, Sowa M. (1996). Role of alpha 2 beta 1- and alpha 3 beta 1-integrin in the peritoneal implantation of scirrhous gastric carcinoma. Br J Cancer 74: 1406-1412. (Pubitemid 26370731)
18. Raaijmakers JH, Deneubourg L, Rehmann H, de Koning J, Zhang Z, Krugmann S et al. (2007). The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. Cell Signal 19: 1249-1257. (Pubitemid 46578336)
19. Sarmiento C, Wang W, Dovas A, Yamaguchi H, Sidani M, El-Sibai M et al. (2008). WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. J Cell Biol 180: 1245-1260. (Pubitemid 351468478)
20. Tanaka M, Sasaki K, Kamata R, Hoshino Y, Yanagihara K, Sakai R. (2009). A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis. Mol Cell Biol 29: 402-413.
21. Uekita T, Tanaka M, Takigahira M, Miyazawa Y, Nakanishi Y, Kanai Y et al. (2008). CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am J Pathol 172: 1729-1739. (Pubitemid 351793363)
22. Yanagihara K, Takigahira M, Tanaka H, Komatsu T, Fukumoto H, Koizumi F et al. (2005). Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer. Cancer Sci 96: 323-332. (Pubitemid 41007466)
23. Yeatman TJ. (2004). A renaissance for SRC. Nat Rev Cancer 4: 470-480. (Pubitemid 38745532)
24. Yoon HY, Lee JS, Randazzo PA. (2008). ARAP1 regulates endocytosis of EGFR. Traffic 9: 2236-2252.