Parthenolide blocks cocaine's effect on spontaneous firing activity of dopaminergic neurons in the Ventral Tegmental Area

Current Neuropharmacology

Volumn 9, Issue 1, 2011, Pages 17-20

  Schwarz, David ^a   Bloom, Damaris ^b   Castro, Rocío ^b   Pagán, Oné R ^c   Jimenez Rivera C A ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b Escuela Medicina   (United States)

^c WEST CHESTER UNIVERSITY   (United States)

Author keywords

Cocaine; Dopamine; Firing activity; Parthenolide; Ventral tegmental

Indexed keywords

COCAINE; PARTHENOLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG INHIBITION; LOCOMOTION; MALE; NONHUMAN; RAT; VENTRAL TEGMENTUM;

EID: 79953055046     PISSN: 1570159X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157015911795017010     Document Type: Article

References (14)

1. Alcaro, A., Huber, R., Panksepp, J. Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective. Br. Res. Rev., 2007, 56, 283-321.
2. Schultz, W. Multiple dopamine functions at different time courses. Annu. Rev. Neurosci., 2007, 30, 259-288.
3. Ritz, M.C., Cone E., Kuhar, M. Cocaine inhibition of ligand binding at dopamine, nor epinephrine and serotonin transporters: a structure-activity study. Life Sci., 1990, 46, 635-645.
4. Pagán, O., Rowlands, A., Azam, M., Urban, K., Bidja, A., Roy, D., Feeney, R.B., Afshari, L.K. Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones. Pharmacol. Biochem. Behav., 2008, 89(2), 160-170.
5. Mejías-Aponte, C.A., Drouin, C., Aston-Jones, G. Adrenergic and noradrenergic innervation of the midbrain ventral tegmental area and retrorubral field: prominent inputs from medullary homeostatic centers. J. Neurosci., 2009, 29, 3613-3626.
6. Paxinos, G., Watson, C. The brain in stereotaxic coordinates. Academic Press: San Diego, 1986.
7. Rowlands, A., Pagán, O. Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians. Eur. J. Pharm., 2008, 583(1), 170-172.
8. Marinelli, M., Rudick, C.N., Hu, X.T., White, F.J. Excitability of dopamine neurons: Modulation and physiological consequences. CNS. Neurol. Disord-Drug Targets, 2006, 5, 79-97.
9. Hehner, S., Hofmann, T., Dröge, W., Schmitz, M. The anti-inflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. J. Immunol., 1999, 163, 5617-5623.
10. Appell, M., Berfield, J.L., Wang, L.C., Dunn, W. J., Chen, N., Reith, M.E. Structure-activity relationships for substrate recognition by the human dopamine transporter. Biochem. Pharmacol., 2004, 67, 293-302.
11. Bradberry, C.W., Roth, R.H. Cocaine increases extracellular dopamine in rat nucleus accumbens and ventral tegmental area as shown by in vivo microdialysis. Neurosci. Lett., 1989, 103, 97-102.
12. Schultz, W. Getting formal with dopamine and reward. Neuron, 2002, 36, 241-263.
13. Einhorn, L.C., Johansen, P.A., White, F.J. Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area. J. Neurosci., 1988, 8, 100-112.
14. Meltzer, P.C., Liu, S., Blanchette, H., Blundell, P., Madras, B.K. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorg. Med. Chem., 2002, 10, 3583-3591.