BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution

ChemMedChem

Volumn 6, Issue 4, 2011, Pages 667-677

  Briard, Emmanuelle ^a   Orain, David ^a   Beerli, Christian ^a   Billich, Andreas ^a   Streiff, Markus ^a   Bigaud, Marc ^a   Auberson, Yves P ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Imaging agents; Iodine; Myelin; Positron emission tomography

Indexed keywords

2 AMINO 2 [2 (2 IODO 4 OCTYLPHENYL)ETHYL] 1,3 PROPANDIOL; 2 AMINO 2 [2 (3 IODO 4 OCTYLPHENYL)ETHYL] 1,3 PROPANDIOL; 2 AMINO 2 [2 [3 IODO 4 (HEPTYLOXY)PHENYL]ETHYL] 1,3 PROPANEDIOL; 2 AMINO 2 [2 [4 (5 IODOHEX 5 ENYLOXY)PHENYL]ETHYL]PROPANE 1,3 DIOL; 2 AMINO 2 [2 [4 (6 IODOHEX 5 ENYLOXY)PHENYL]ETHYL]PROPANE 1,3 DIOL; AML 629; BZM 055; FINGOLIMOD; IODINATED CONTRAST MEDIUM; IODINE 123; IODINE 124; MYELIN; PHOSPHORIC ACID MONO [2 AMINO 2 HYDROXYMETHYL 4 (2 IODO 4 OCTYLPHENYL)BUTYL]ESTER; PHOSPHORIC ACID MONO [2 AMINO 2 HYDROXYMETHYL 4 (3 IODO 4 OCTYLPHENYL)BUTYL]ESTER; PHOSPHORIC ACID MONO [2 AMINO 2 HYDROXYMETHYL 4 [4 (5 IODOHEX 5 ENYLOXY)PHENYL]BUTYL]ESTER; PHOSPHORIC ACID MONO [2 AMINO 2 HYDROXYMETHYL 4 [4 (6 IODOHEX 5 ENYLOXY)PHENYL]BUTYL]ESTER; PHOSPHORIC ACID MONO [2 AMINO 4 (4 HEPTYLOXY 3 IODOPHENYL) 2 HYDROXYMETHYLBUTYL]ESTER; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; HUMAN; IODINATION; ISOTOPE LABELING; LIVER MICROSOME; LYMPHOCYTE DEPLETION; MALE; MAXIMUM PLASMA CONCENTRATION; MYELIN SHEATH; NONHUMAN; ORGAN DISTRIBUTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

BRAIN; HUMANS; IODINE RADIOISOTOPES; KINETICS; MULTIPLE SCLEROSIS; MYELIN SHEATH; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, LYSOSPHINGOLIPID; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 79953033920     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000477     Document Type: Article

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