DNA immunization of pigs with foot-and-mouth disease virus minigenes: From partial protection to disease exacerbation

Virus Research

Volumn 157, Issue 1, 2011, Pages 121-125

  Ganges, Llilianne ^a,b   Borrego, Belén ^b   Fernández Pacheco, Paloma ^b   Revilla, Concepción ^b   Fernández Borges, Natalia ^a   Domínguez, Javier ^b   Sobrino, Francisco ^b,c   Rodriguez, Fernando ^a  

^a CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

^b INIA   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Cellular response; DNA vaccine; FMDV; IL 10; Leukopenia

Indexed keywords

DNA VACCINE; EPITOPE; FOOT AND MOUTH DISEASE VACCINE; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DNA IMMUNIZATION; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; ANTIBODIES, VIRAL; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, T-LYMPHOCYTE; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; IMMUNIZATION; INTERLEUKIN-10; SWINE; SWINE DISEASES; VACCINES, DNA; VIRAL VACCINES;

FOOT-AND-MOUTH DISEASE VIRUS; SUIDAE;

EID: 79953029879     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2011.02.003     Document Type: Article

References (32)

1. Alvarez B., Sanchez C., Bullido R., Marina A., Lunney J., Alonso F., Ezquerra A., Domínguez J. A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1. Tissue Antigens 2000, 55:342-351.
2. Baenziger J., Hengartner H., Zinkernagel R.M., Cole G.A. Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur. J. Immunol. 1986, 1:387-393.
3. Barnard A.L., Arriens A., Cox S., Barnett P., Kristensen B., Summerfield A., McCullough K.C. Immune response characteristics following emergence vaccination of pigs against foot-and-mouth disease. Vaccine 2005, 23:1037-1047.
4. Bautista E.M., Ferman G.S., Golde W.T. Induction of lymphopenia and inhibition of T cell function during acute infection of swine with foot and mouth disease virus (FMDV). Vet. Immunol. Immunopathol. 2003, 92:61-67.
5. Borrego B., Fernandez-Pacheco P., Ganges L., Domenech N., Fernandez-Borges N., Sobrino F., Rodriguez F. DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses. Vaccine 2006, 24:3889-3899.
6. Bullido R., Domenech N., Alvarez B., Alonso F., Babín M., Ezquerra A., Ortuno E., Domínguez J. Characterization of five monoclonal antibodies specific for swine class II major histocompatibility antigens and crossreactivity studies with leukocytes of domestic animals. Dev. Comp. Immunol. 1997, 21:311-322.
7. Bullido R., Ezquerra A., Alonso F., Gomez del Moral M., Domínguez J. Characterization of a new monoclonal antibody (4B7) specific for porcine MHC (SLA) class I antigens. Investig. Agrar. Prod. Sanid. Anim. 1996, 11:29-37.
8. Capozzo A.V., Periolo O.H., Robiolo B., Seki C., La Torre J.L., Grigera P.R. Total and isotype humoral responses in cattle vaccinated with foot and mouth disease virus (FMDV) immunogen produced either in bovine tongue tissue or in BHK-21 cell suspension cultures. Vaccine 1997, 15:624-630.
9. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. J. Immunol. 2008, 180:5771-5777.
10. Cubillos C., de la Torre B.G., Jakab A., Clementi G., Borras E., Barcena J., Andreu D., Sobrino F., Blanco E. Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide. J. Virol. 2008, 82:7223-7230.
11. Diaz-San Segundo F., Salguero F.J., de Avila A., de Marco M.M., Sanchez-Martin M.A., Sevilla N. Selective lymphocyte depletion during the early stage of the immune response to foot-and-mouth disease virus infection in swine. J. Virol. 2006, 80:2369-2379.
12. Díaz-San Segundo F., Rodríguez-Calvo T., de Avila A., Sevilla N. Immunosuppression during acute infection with foot-and-mouth disease virus in swine is mediated by IL-10. PLoS One 2009, 21:e5659.
13. Doel T.R. FMD vaccines. Virus Res. 2003, 91:81-99.
14. Domingo E., Baranowski E., Escarmis C., Sobrino F. Foot-and-mouth disease virus. Comp. Immunol. Microbiol. Infect. Dis. 2003, 25:297-308.
15. Fleischer B., Vallbracht A. Demonstration of virus-specific cytotoxic T lymphocytes in liver tissue in hepatitis A-a model for immunopathological reactions. Behring. Inst. Mitt. 1991, 226-230.
16. Gerner W., Kaser T., Saalmuller A., Porcine T lymphocytes and NK cells-an update. Devel. Comp. Immunol. 2009, 33:310-320.
17. Grubman M.J., Moraes M.P., Diaz-San Segundo F., Pena L., de los Santos T. Evading the host immune response: how foot-and-mouth disease virus has become an effective pathogen. FEMS Immunol. Med. Microbiol. 2008, 53:8-17.
18. Hohlich B.J., Wiesmuller K.H., Haas B., Gerner W., Correa R., Hehnen H.R., Schlapp T., Pfaff E., Saalmüller A. Induction of an antigen-specific immune response and partial protection of cattle against challenge infection with foot-and-mouth disease virus (FMDV) after lipopeptide vaccination with FMDV-specific B-cell epitopes. J. Gen. Virol. 2003, 84:3315-3324.
19. Kondo Y., Kobayashi K., Asabe S., Shiina M., Niitsuma H., Ueno Y., Kobayashi T., Shimosegawa T. Vigorous response of cytotoxic T lymphocytes associated with systemic activation of CD8 T lymphocytes in fulminant hepatitis B. Liver Int. 2004, 24:561-567.
20. Li M.O., Flavell R.A. Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity 2008, 28:468-476.
21. Mateu M.G., Rocha E., Vicente O., Vayreda F., Navalpotro C., Andreu D., Pedroso E., Giralt E., Enjuanes L., Domingo E. Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease. Virus Res. 1987, 8:261-274.
22. Mumford J.A. Vaccines and viral antigenic diversity. Rev. Sci. Technol. 2007, 26:69-90.
23. Murphy J.B., Bashiruddin M., Quan Z., Zhang S., Alexandersen C. Foot-and-mouth disease viral loads in pigs in the early, acute stage of disease. Vet. Rec. 2010, 166:10-14.
24. Nfon C.K., Toka F.N., Kenney M., Pacheco J.M., Golde W.T. Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease virus infection. Viral Immunol. 2010, 23:29-41.
25. Osorio Y., Cai S., Hofman F.M., Brown D.J., Ghiasi H. Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice. Curr. Eye Res. 2004, 29:145-151.
26. Parida S. Vaccination against foot-and-mouth disease virus: strategies and effectiveness. Expert Rev. Vaccines 2009, 8:347-365.
27. Rigden R.C., Carrasco C.P., Barnett P.V., Summerfield A., McCullough K.C. Innate immune responses following emergence vaccination against foot-and-mouth disease virus in pigs. Vaccine 2003, 21:1466-1477.
28. Saiz M., De La Morena D.B., Blanco E., Nunez J.I., Fernandez R., Sanchez-Vizcaino J.M. Detection of foot-and-mouth disease virus from culture and clinical samples by reverse transcription-PCR coupled to restriction enzyme and sequence analysis. Vet. Res. 2003, 34:105-117.
29. Takamatsu H.H., Denyer M.S., Stirling C., Cox S., Aggarwal N., Dash P., Wileman T.E., Barnett P.V. Porcine gammadelta T cells: possible roles on the innate and adaptive immune responses following virus infection. Vet. Immunol. Immunopathol. 2006, 112:49-61.
30. van Bekkum J.G., Fish R.C., Nathans I. Immunologic responses in Dutch cattle vaccinated with foot-and-mouth disease vaccines under field conditions: neutralizing antibody responses and immunity to O, A, and C types. Am. J. Vet. Res. 1969, 30:2125-2129.
31. van Drunen Littel-van den Hurk S., Babiuk S.L., Babiuk L.A. Strategies for improved formulation and delivery of DNA vaccines to veterinary target species. Immunol. Rev. 2004, 199:113-125.
32. Zheng M., Jin N., Zhang H., Jin M., Lu H., Ma M., Li C., Yin G., Wang R., Liu Q. Construction and immunogenicity of a recombinant fowlpox virus containing the capsid and 3C protease coding regions of foot-and-mouth disease virus. J. Virol. Methods 2006, 136:230-237.