5-Methoxyaristololactam I, the first natural 5-substituted aristololactam from Asarum ichangense

Natural Product Communications

Volumn 6, Issue 1, 2011, Pages 11-14

  Xie, Bai Bo ^a,b   Shang, Ming Ying ^a   Lee, Kuo Hsiung ^b   Wang, Xuan ^a   Komatsu, Katsuko ^c   Cai, Shao Qing ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

5 Methoxyaristololactam I; Aristolochiaceae; Asarum ichangense

Indexed keywords

2,3 METHYLENEDIOXY 4,5,6 TRIMETHOXYALLYLBENZENE; 5 HYDROXY 3,7 DIMETHOXY 3',4' METHYLENEDIOXYFLAVONE; 5 METHOXYARISTOLOLACTAM I; ALCOHOL; ARISTOLOLACTAM; ASARUM ICHANGENSE EXTRACT; N ISOBUTYLCINNAMAMIDE; PLANT EXTRACT; UNCLASSIFIED DRUG; VACCINPEROXYPYRAN; 5-METHOXYARISTOLOLACTAM I; BIOLOGICAL PRODUCT; LACTAM;

ARTICLE; ASARUM; ASARUM ICHANGENSE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; HETERONUCLEAR MULTIPLE BOND CORRELATION; ISOLATION PROCEDURE; MEDICINAL PLANT; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; SOLVENT EXTRACTION; STRUCTURE ANALYSIS; ARISTOLOCHIACEAE; CHEMISTRY; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ARISTOLOCHIACEAE; ASARUM;

ARISTOLOCHIACEAE; ASARUM; BIOLOGICAL PRODUCTS; LACTAMS; MAGNETIC RESONANCE SPECTROSCOPY;

EID: 79953008922     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1100600104     Document Type: Article

References (28)

1. Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edita. (1988) Flora Republicae Popularis Sinicae. Science Press, Beijing, Tomus 24, p 165.
2. The State Pharmacopoeia Committee of China. (2005) Pharmacopoeia of the People's Republic of China, vol. 1. Chemical Industry Publisher Press, Beijing. 159.
3. Editorial Committee of Chinese Materia Medica, the Administration Bureau of Traditional Chinese Medicine. (2000) Chinese Materia Medica (Zhonghua Bencao), Shanghai Science & Technology, Shanghai, vol.8, p 487.
4. Zhang SX, Tani T, Yamaji S, Ma CM, Wang MC, Cai SQ, Zhao YY. (2003) Glycosyl flavonoids from the roots and rhizomes of Asarum longerhizomatosum. Journal of Asian Natural Products Research, 5, 25-30. (Pubitemid 36142540)
5. Zhang SX, Tani T, Yamaji S, Gao XL, Wang X, Cai SQ, Zhao YY. (2002) Studies on chemical constituents from root and rhizome of Asarum longerhizomatosum. Chinese Traditional and Herbal Drugs (Zhongcaoyao), 33, 297-299.
6. Zhang SX, Cai SQ, Zhao YY. (2001) Studies on chemical constituents of Asarum longerhizomatosum. China Journal of Chinese Materia Medica (Zhongguo Zhongyao Zazhi), 26, 762-763.
7. Yu J, Ma CM, Long CF, Wang, X, Shang MY, Cai SQ, Hattori M, Namba T. (2009) A new aristololactam from Asarum maximum. Journal of Chinese Pharmaceutical Sciences, 18, 183-185.
8. Wang X, Long CF, Cai SQ, Zhao YY. (2000) Chemical constituents of the root of Asarum maximum. Chinese Traditional and Herbal Drugs (Zhongcaoyao), 31, 888-890.
9. Long CF, Wang X, Yang YX, Cai SQ. (2000) Studies on flavonoids from root of Asarum maximum. Journal of Beijing Medical University (Beijing Yike Daxue Xuebao), 32, 229-231.
10. Cai SQ, Wang H, Chen SZ, Lou ZC. (1996) Studies on the non-volatile chemical constituents of Asarum heterotropoides var. mandshuricum. Journal of Beijing Medical University (Beijing Yike Daxue Xuebao), 28, 228-230.
11. Wu QL, Wang SP, Tu GZ, Feng YX, Yang JS. (1997) Alkaloids from Piper puberullum. Phytochemistry, 44, 727-730.
12. David BM, Guinaudea H, Shamma M. (1982) The aristolochic acids and aristolactams. Journal of Natural Products, 45, 657-666.
13. Leu YL, Chan YY, Wu TS. (1998) Sodium aristolochate derivatives from leaves of Aristolochia foveolata. Phytochemistry, 48, 743-745.
14. Yamamura S, Niwa M, Terada Y, Nonoyama M. (1982) The isolation and structures of novel neolignans and neosesquilignans from Heterotropa takaoi M. Bulletin of the Chemical Society of Japan, 55, 3573-3579. (Pubitemid 13189795)
15. Yamamura S, Terada Y, Chen Y-P, Hong M, Hsu H-Y, Sasaki K, Hirata Y. (1976) The structures of two novel neolignans, asatone and isoasatone. Bulletin of the Chemical Society of Japan, 49, 1940-1948.
16. Rahman A, Choudhary MI, Hayat S, Khan AM, Ahmad A, Malik S. (1999) Spatozoate and varninasterol from the brown alga Spatoglossum variabile. Phytochemistry, 52, 495-499. (Pubitemid 29436354)
17. Nishida R, Tan KH, Wee SL, Hee AK, Toong YC. (2004) Phenylpropanoids in the fragrance of the fruit fly orchid, Bulbophyllum cheiri, and their relationship to the pollinator, Bactrocera papayae. Biochemical Systematics and Ecology, 32, 245-252. (Pubitemid 38215052)
18. Higa M, Ohshiro T, Ogihara K, Yogi S. (1990) Flavonoid constituents of Melicope triphylla Merr. II. Yakugaku Zasshi, 110, 822-827.
19. Li J, Li F, Lu Y-Y, Wen G-Q, Su XJ. (2007) Study on the antiphlogistic constituents in seed of Schisandra propinqua (Wall) Hook. f. et Thoms. Chinese Pharmaceutical Journal (Zhongguo Yaoxue Zazhi), 42, 255-257. (Pubitemid 47242129)
20. Kazunori H, Takao K, Kazuaki N, Yukinobu I, Minoru O, Hiroshi M. (1992) Two glycosides from roots of Asiasarum sieboldii. Phytochemistry, 31, 2477-2480.
21. Iwashina T, Kitajima J. (2000) Chalcone and flavonol glycosides from Asarum canadense (Aristolochiaceae). Phytochemistry, 55, 971-974.
22. Huang ZZ, Wu LL. (1996) Stereoselective synthesis of (2E)-α,β- unsaturated amides. Chinese Journal of Organic Chemistry (Youji Huaxue), 16, 340-343.
23. He XJ, Liu RH. (2006) Cranberry phytochemicals: isolation, structure elucidation, and their antiproliferative and antioxidant activities. Journal of Agricultural and Food Chemistry, 54, 7069-7074.
24. Hai LQ, Liang H, Zhao YY, Du NS. (2002) Studies on chemical constituents in the root of Hedysarum polybotrys. China Journal of Chinese Materia Medica (Zhongguo Zhongyao Zazhi), 27, 843-845.
25. Lord GM, Tagore R, Cook,T, Gower P, Pusey CD. (1999) Nephropathy caused by Chinese herbs in the UK. Lancet, 354, 481-483.
26. Li B, Li XM, Zhang CY, Wang X, Cai SQ. (2004) Cellular mechanism of renal proximal tubular epithelial cell injury induced by aristolochic acid I and aristololactam I. Journal of Peking University (Beijing Daxue Xuebao), 36, 36-40.
27. Li B, Li XM, Zhang CY, Wang X, Cai SQ. (2004) Injury in renal proximal tubular epithelial cells induced by aristololactam I. China Journal of Chinese Materia Medica (Zhongguo Zhongyao Zazhi), 29, 78-83.
28. Wen YJ, Su T, Tang JW, Zhang CY, Wang X, Cai SQ, Li XM. (2006) Cytotoxicity of phenanthrenes extracted from Aristolochia contorta in human proximal tubular epithelial cell line. Nephron Experimental Nephrology, 103, e95-e102. (Pubitemid 43952614)