Effects of interior gelation on pharmacokinetics and biodistribution of liposomes encapsulating an anti-cancer drug cytarabine

Journal of Biomedical Nanotechnology

Volumn 6, Issue 6, 2010, Pages 704-709

  Zhang, Bei ^a   Lu, Yi ^a   Chen, Jian ^a   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Biodistribution; Cytarabine; Gelliposomes; Pharmacokinetics; Thermosensitive in situ gel

Indexed keywords

ANTICANCER DRUG; BIODISTRIBUTIONS; CYTARABINE; FILM DISPERSION; GELLIPOSOMES; IN-VIVO; INTRAVENOUS INJECTIONS; LIPOSOMAL FORMULATION; MEAN SIZE; MODEL DRUGS; NARROW SIZE DISTRIBUTIONS; PHYSICAL STABILITY; PHYSICOCHEMICAL PROPERTY; RESIDENT TIME; SUSTAINED RELEASE; THERMO SENSITIVE;

COAGULATION; DRUG PRODUCTS; GELATION; GELS; LIPID BILAYERS; PHARMACOKINETICS; PHOSPHOLIPIDS; TISSUE; ZETA POTENTIAL;

LIPOSOMES;

CYTARABINE; GELLIPOSOME; LIPOSOME; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; FILM; GELATION; INTERIOR GELATION; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; RAT; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; GEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROCAPSULE; SPRAGUE DAWLEY RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; CAPSULES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTARABINE; DRUG DELIVERY SYSTEMS; GELS; LIPOSOMES; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79953005805     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2010.1162     Document Type: Article

References (30)

1. M. J. Keating, K. B. McCredie, and G. P. Bodey, Improved prospects for long-term survival in adults with acute myelogenous leukemia. J. Am. Med. Assoc. 248, 2481 (1982).
2. A. Hamada, T. Kawaguchi, and M. Nakano, Clinical pharmacokinetics of cytarabine formulations. Clin. Pharmacokinet. 41, 705 (2002).
3. F. L. Graham and G. F. Whitmore, The effect of 1-beta-D- arabinofuranosylcytosine on growth, viability, and DNA synthesis of mouse L-cells. Cancer Res. 30, 2627 (1970).
4. H. D. Han, A. Lee, T. Hwang, C. K. Song, H. Seong, J. Hyun, and B. C. Shin, Enhanced circulation time and antitumor activity of doxorubicin by comblike polymer-incorporated liposomes. J. Controlled Release 120, 161 (2007).
5. W. Plunkett, J. O. Liliemark, E. Estey, and M. J. Keating, Saturation of ara-CTP accumulation during high-dose ara-C therapy: Pharmacologic rationale for intermediate-dose ara-C. Semin. Oncol. 14, 159 (1987).
6. Y M. Rustum, C. Dave, E. Mayhew, and D. Papahadjopoulos, Role of liposome type and route of administration in the antitumor activity of liposome-entrapped 1-beta-D-arabinofuranosylcytosine against mouse L1210 leukemia. Cancer Res. 39, 1390 (1979).
7. R. Ganapathi, A. Krishan, I. Wodinsky, C. G. Zubrod, and L. J. Lesko, Effect of cholesterol content on antitumor activity and toxicity of liposome-encapsulated 1-beta-D-arabinofuranosylcytosine in vivo. Cancer Res. 40, 630 (1980).
8. H. Ellens, Y. Rustum, E. Mayhew, and E. Ledesma, Distribution and metabolism of lipsome-encapsulated and free 1-beta-D-arabinofuranosylcytosine (Ara-C) in dog and mouse tissues. J. Pharmacol. Exp. Ther. 222, 324 (1982).
9. A. Alaouie and S. Sofou, Liposomes with triggered content release for cancer therapy. J. Biomed. Nanotechnol. 4, 234 (2008).
10. F. Fang, C. Gong, Z. Qian, X. Zhang, M. Gou, C. You, L. Zhou, J. Liu, Y. Zhang, G. Guo, Y. Gu, F. Luo, L. Chen, X. Zhao, and Y. Wei, Honokiol nanoparticles in thermosensitive hydrogel: Therapeutic effects on malignant pleural effusion. ACS Nano. 3, 4080 (2009).
11. M. Gou, X. Zheng, K. Men, J. Zhang, B. Wang, Y. Zhao, F. Luo, L. Chen, X. Zhao, Y. Wei, and Z. Qian, Self-assembled hydrophobic honokiol loaded MPEG-PCL diblock copolymer micelles. Pharm. Res. 26, 2164 (2009).
12. D. Prajakta, J. Ratnesh, K. Chandan, S. Suresh, S. Grace, V. Meera, and P. Vandana, Curcumin loaded pH-Sensitive nanoparticles for the treatment of colon cancer. J. Biomed. Nanotechnol. 5, 445 (2009).
13. A. Estella-Hermoso de Mendoza, M. A. Campanero, F. Mollinedo, and M. J. Blanco-Prieto, Lipid nanomedicines for anticancer drug therapy. J. Biomed. Nanotechnol. 5, 323 (2009).
14. K. R. Patel and J. D. Baldeschwieler, Treatment of intravenously implanted Lewis lung carcinoma with liposome-encapsulated cytosine arabinoside and non-specific immunotherapy. Int. J. Cancer 34, 415 (1984).
15. N. W. Fu, Influencing factors in the leakage of liposome and arabinoside cytosine (ARA-C) entrapped in liposomes in treatment of L1210 mouse leukemia. Chin. J. Oncol. 7, 250 (1985).
16. A. Sharma and U. S. Sharma, Liposomes in drug delivery: Progress and limitations. Int. J. Pharm. 154, 123 (1997).
17. S. Kazakov and K. Levon, Liposome-nanogel structures for future pharmaceutical applications. Curr. Pharm. Des. 12, 4713 (2006).
18. S. S. Feng, G. Ruan, and Q. T. Li, Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM). Biomaterials. 25, 5181 (2004).
19. E. Ruel-Gariépy, G. Leclair, P. Hildgen, A. Gupta, and J. C. Leroux, Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules. J. Controlled Release 82, 373 (2002).
20. E. Ruel-Gariépy, M. Shive, A. Bichara, M. Berrada, D. Le Garrec, A. Chenite, and J. C. Leroux, A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel. Eur. J. Pharm. Biopharm. 57, 53 (2004).
21. W. W. Zou, W. T. Sun, N. Zhang, and W. F. Xu, Enhanced oral bioavailability and absorption mechanism study of N3-O-Toluyl-Fluorouracil- Loaded Liposomes. J. Biomed. Nanotechnol. 4, 90 (2008).
22. B. Zhang, J. Chen, Y. Lu, Y. Chen, J. Le, and W. Wu, Liposomes with gelated interior as novel drug delivery carriers. Manuscript.
23. V. D. Awasthi, D. Garcia, B. A. Goins, and W. T. Phillips, Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits. Int. J. Pharm. 253, 121 (2003).
24. M. Hara and J. Miyake, Calcium alginate gel-entrapped liposomes. Mater. Sci. Eng. C. 17, 101 (2001).
25. Y. Li, N. S. Liang, J. S. Wei, and Y. Lu, Determination of Cytarabine in Human Plasma by HPLC. China Pharm. 17, 1316 (2006).
26. S. Phuphanich, B. Maria, R. Braeckman, and M. Chamberlain, A pharmacokinetic study of intra-CSF administered encapsulated cytarabine (DepoCyt) for the treatment of neoplastic meningitis in patients with leukemia, lymphoma, or solid tumors as part of a phase III study. J. Neurooncol. 81, 201 (2007).
27. M. L. Stout and Y. Ravindranath, Alkylsulphonic acid ion pairing with radial compression columns for determining plasma or cerebrospinal fluid 1-beta-D-arabinofuranosylcytosine in pediatric pharmacokinetic analysis. J. Chromatogr. A 692, 59 (1995).
28. H. Harashima and H. Kiwada, Liposomal targeting and drug delivery: Kinetic consideration. Adv. Drug Deliv. Rev. 19, 425 (1996).
29. V. P. Torchilin and V. S. Trubetskoy, Which polymers can make nanoparticulate drug carriers long-circulating? Adv. Drug Deliv. Rev. 16, 141 (1995).
30. S. M. Moghimi, Mechanisms of splenic clearance of blood cells and particles: Towards development of new splenotropic agents. Adv. Drug Deliv. Rev. 17, 103 (1995).