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Volumn 16, Issue 3, 2011, Pages 327-335

Outcomes of patients with advanced non-small cell lung cancer treated in a phase I clinic

Author keywords

Non small cell lung cancer; Phase I; Survival

Indexed keywords

ANGIOPOIETIN INHIBITOR; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BORTEZOMIB; CARBOPLATIN; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEMCITABINE; HEMOGLOBIN; IMEXON; PACLITAXEL; PLATINUM COMPLEX; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR;

EID: 79953004809     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2010-0308     Document Type: Review
Times cited : (7)

References (54)
  • 1
    • 67650951467 scopus 로고    scopus 로고
    • National Cancer Institute, Estimated New Cancer Cases and Deaths for 2009. Available at, accessed November 29
    • National Cancer Institute. SEER Cancer Statistics Review 1975-2006. Estimated New Cancer Cases and Deaths for 2009. Available at http://www.seer.cancer.gov/csr/1975_2006/results_single/sect_01_table.01.pdf, accessed November 29, 2010.
    • (2010) SEER Cancer Statistics Review 1975-2006
  • 3
    • 53749097825 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of individual patient data from 16 randomized controlled trials
    • Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer
    • Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: A systematic review and meta-analysis of individual patient data from 16 randomized controlled trials. J Clin Oncol 2008;26:4617-4625.
    • (2008) J Clin Oncol , vol.26 , pp. 4617-4625
  • 4
    • 0028895649 scopus 로고
    • Symptom relief with MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in advanced non-small-cell lung cancer
    • Ellis PA, Smith IE, Hardy JR et al. Symptom relief with MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in advanced non-small-cell lung cancer. Br J Cancer 1995;71:366-370.
    • (1995) Br J Cancer , vol.71 , pp. 366-370
    • Ellis, P.A.1    Smith, I.E.2    Hardy, J.R.3
  • 5
    • 0034069620 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
    • Shepherd FA, Dancey J, Ramlau R et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 2000;18:2095-2103.
    • (2000) J Clin Oncol , vol.18 , pp. 2095-2103
    • Shepherd, F.A.1    Dancey, J.2    Ramlau, R.3
  • 6
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N, Shepherd FA, Fossella FV et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004;22:1589-1597.
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 7
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-132.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues P., J.2    Ciuleanu, T.3
  • 8
    • 70350599566 scopus 로고    scopus 로고
    • Chemotherapy for lung cancer: The state of the art in 2009
    • Higgins MJ, Ettinger DS. Chemotherapy for lung cancer: The state of the art in 2009. Expert Rev Anticancer Ther 2009;9:1365-1378.
    • (2009) Expert Rev Anticancer Ther , vol.9 , pp. 1365-1378
    • Higgins, M.J.1    Ettinger, D.S.2
  • 9
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92: 205-216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 10
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, StadlerWM et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24:2505-2512.
    • (2006) J Clin Oncol , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 11
    • 3242881591 scopus 로고    scopus 로고
    • Cancer Therapy Evaluation Program, Available at, accessed February 4
    • Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events v3.0 (CTCAE). Available at http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf, accessed February 4, 2010.
    • (2010) Common Terminology Criteria for Adverse Events V3.0 (CTCAE).
  • 12
    • 33845382806 scopus 로고
    • Nonparametric estimator from incomplete observations
    • Kaplan EM, Meier P. Nonparametric estimator from incomplete observations. J Am Stat Assoc 1958;53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.M.1    Meier, P.2
  • 13
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-170.
    • (1966) Cancer Chemother Rep , vol.50 , pp. 163-170
    • Mantel, N.1
  • 14
    • 0000336139 scopus 로고
    • Regression models and life tables (with discussion)
    • Cox D. Regression models and life tables (with discussion). J R Stat Soc Series B Stat Methodol 1972;34:187-220.
    • (1972) J R Stat Soc Series B Stat Methodol , vol.34 , pp. 187-220
    • Cox, D.1
  • 15
    • 59349096968 scopus 로고    scopus 로고
    • Phase I multicenter trial of BMS-690514: Safety, pharmacokinetic profile, biological effects, and early clinical evaluation in patients with advanced solid tumors and non-small cell lung cancer
    • Abstract 2564
    • Bahleda RF, Herbst E, Hanna RS et al. Phase I multicenter trial of BMS-690514: Safety, pharmacokinetic profile, biological effects, and early clinical evaluation in patients with advanced solid tumors and non-small cell lung cancer. J Clin Oncol 2008;26:Abstract 2564.
    • (2008) J Clin Oncol , vol.26
    • Bahleda, R.F.1    Herbst, E.2    Hanna, R.S.3
  • 16
    • 45749105225 scopus 로고    scopus 로고
    • First-in-human study ofAMG655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors
    • Abstract 3534
    • LoRusso PH, Heath D, Kurzrock E et al. First-in-human study ofAMG655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors. J Clin Oncol 2007;25:Abstract 3534.
    • (2007) J Clin Oncol , vol.25
    • LoRusso, P.H.1    Heath, D.2    Kurzrock, E.3
  • 17
    • 34347235531 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors
    • Rosen LS, Kurzrock R, Mulay M et al. Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors. J Clin Oncol 2007;25:2369-2376.
    • (2007) J Clin Oncol , vol.25 , pp. 2369-2376
    • Rosen, L.S.1    Kurzrock, R.2    Mulay, M.3
  • 18
    • 77949369418 scopus 로고    scopus 로고
    • Phase 1 pharmacokinetic and druginteraction study of dasatinib in patients with advanced solid tumors
    • Johnson FM, Agrawal S, Burris H et al. Phase 1 pharmacokinetic and druginteraction study of dasatinib in patients with advanced solid tumors. Cancer 2010;116:1582-1591.
    • (2010) Cancer , vol.116 , pp. 1582-1591
    • Johnson, F.M.1    Agrawal, S.2    Burris, H.3
  • 19
    • 44749091927 scopus 로고    scopus 로고
    • A phase I safety and pharmacokinetic study of apomab, a human DR5 agonist antibody, in patients with advanced cancer
    • Abstract 3582
    • Camidge DH, Gordon RS, Eckhardt M et al. A phase I safety and pharmacokinetic study of apomab, a human DR5 agonist antibody, in patients with advanced cancer. J Clin Oncol 2007;25:Abstract 3582.
    • (2007) J Clin Oncol , vol.25
    • Camidge, D.H.1    Gordon, R.S.2    Eckhardt, M.3
  • 20
    • 68049109550 scopus 로고    scopus 로고
    • A phase I clinical trial of darinaparsin in patients with refractory solid tumors
    • Tsimberidou AM, Camacho LH, Verstovsek S et al. A phase I clinical trial of darinaparsin in patients with refractory solid tumors. Clin Cancer Res 2009;15:4769-4776.
    • (2009) Clin Cancer Res , vol.15 , pp. 4769-4776
    • Tsimberidou, A.M.1    Camacho, L.H.2    Verstovsek, S.3
  • 21
    • 70249114453 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
    • Herbst RS, Hong D, Chap L et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009;27:3557-3565.
    • (2009) J Clin Oncol , vol.27 , pp. 3557-3565
    • Herbst, R.S.1    Hong, D.2    Chap, L.3
  • 22
    • 45349105034 scopus 로고    scopus 로고
    • Two phase 1 studies of MPC-6827, a novel vascular disrupting agent (VDA), in patients with advanced solid tumors and CNS metastases
    • Abstract 3604
    • Kurzrock RA, Hong W, Ng D et al. Two phase 1 studies of MPC-6827, a novel vascular disrupting agent (VDA), in patients with advanced solid tumors and CNS metastases. J Clin Oncol 2007;25:Abstract 3604.
    • (2007) J Clin Oncol , vol.25
    • Kurzrock, R.A.1    Hong, W.2    Ng, D.3
  • 23
    • 59349098682 scopus 로고    scopus 로고
    • Phase I multicenter study to assess the safety, tolerability, and pharmacokinetics of AZD4877 administered twice weekly in adult patients with advanced solid malignancies
    • Abstract 2516
    • Stephenson JL, Martin N, Ho JC et al. Phase I multicenter study to assess the safety, tolerability, and pharmacokinetics of AZD4877 administered twice weekly in adult patients with advanced solid malignancies. J Clin Oncol 2008;26:Abstract 2516.
    • (2008) J Clin Oncol , vol.26
    • Stephenson, J.L.1    Martin, N.2    Ho, J.C.3
  • 24
    • 77956056306 scopus 로고    scopus 로고
    • A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer
    • Moulder S, Dhillon N, Ng C et al. A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer. Invest New Drugs 2010;28: 634-640.
    • (2010) Invest New Drugs , vol.28 , pp. 634-640
    • Moulder, S.1    Dhillon, N.2    Ng, C.3
  • 25
    • 77953286484 scopus 로고    scopus 로고
    • Sunitinib in combination with paclitaxel and carboplatin in patients with advanced solid tumors: Updated phase I study results
    • Abstract e14509
    • Heath EB, Cohen GR, LoRusso RB et al. Sunitinib in combination with paclitaxel and carboplatin in patients with advanced solid tumors: Updated phase I study results. J Clin Oncol 2009;27:Abstract e14509.
    • (2009) J Clin Oncol , vol.27
    • Heath, E.B.1    Cohen, G.R.2    lo Russo, R.B.3
  • 26
    • 79953013303 scopus 로고    scopus 로고
    • Age-stratified phase I trial of a combination of bortezomib, gemcitabine, and liposomal doxorubicin in patients with advanced malignancies
    • Abstract 14087
    • Falchook GD, Moulder N, Duvic S et al. Age-stratified phase I trial of a combination of bortezomib, gemcitabine, and liposomal doxorubicin in patients with advanced malignancies. J Clin Oncol 2007;25:Abstract 14087
    • (2007) J Clin Oncol , vol.25
    • Falchook, G.D.1    Moulder, N.2    Duvic, S.3
  • 27
    • 0027932664 scopus 로고
    • Therapeutic response and potential pitfalls in phase I clinical trials of anticancer agents conducted in Japan
    • Itoh K, Sasaki Y, Miyata Y et al. Therapeutic response and potential pitfalls in phase I clinical trials of anticancer agents conducted in Japan. Cancer Chemother Pharmacol 1994;34:451-454.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 451-454
    • Itoh, K.1    Sasaki, Y.2    Miyata, Y.3
  • 28
    • 0025353690 scopus 로고
    • Responses and toxic deaths in phase I clinical trials
    • Decoster G, Stein G, Holdener EE. Responses and toxic deaths in phase I clinical trials. Ann Oncol 1990;1:175-181.
    • (1990) Ann Oncol , vol.1 , pp. 175-181
    • Decoster, G.1    Stein, G.2    Holdener, E.E.3
  • 29
    • 14544284502 scopus 로고    scopus 로고
    • Risks and benefits of phase 1 oncology trials, 1991 through 2002
    • Horstmann E, McCabe MS, Grochow L et al. Risks and benefits of phase 1 oncology trials, 1991 through 2002. N Engl J Med 2005;352:895-904.
    • (2005) N Engl J Med , vol.352 , pp. 895-904
    • Horstmann, E.1    McCabe, M.S.2    Grochow, L.3
  • 30
    • 14544286345 scopus 로고    scopus 로고
    • Risks and benefits of phase 1 oncology trials, revisited
    • Kurzrock R, Benjamin RS. Risks and benefits of phase 1 oncology trials, revisited. N Engl J Med 2005;352:930-932.
    • (2005) N Engl J Med , vol.352 , pp. 930-932
    • Kurzrock, R.1    Benjamin, R.S.2
  • 31
    • 76749161498 scopus 로고    scopus 로고
    • Phase I oncology studies: Evidence that in the era of targeted therapies patients on lower doses do not fare worse
    • Jain RK, Lee JJ, Hong D et al. Phase I oncology studies: Evidence that in the era of targeted therapies patients on lower doses do not fare worse. Clin Cancer Res 2010;16:1289-1297.
    • (2010) Clin Cancer Res , vol.16 , pp. 1289-1297
    • Jain, R.K.1    Lee, J.J.2    Hong, D.3
  • 32
    • 34249093653 scopus 로고    scopus 로고
    • Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer
    • Adjei AA, Molina JR, Mandrekar SJ et al. Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer. Clin Cancer Res 2007;13:2684-2691.
    • (2007) Clin Cancer Res , vol.13 , pp. 2684-2691
    • Adjei, A.A.1    Molina, J.R.2    Mandrekar, S.J.3
  • 33
    • 50349093533 scopus 로고    scopus 로고
    • Phase I/II study of a 3 weekly oral taxane (DJ-927) in patients with recurrent, advanced non-small cell lung cancer
    • Baas P, Szczesna A, Albert I et al. Phase I/II study of a 3 weekly oral taxane (DJ-927) in patients with recurrent, advanced non-small cell lung cancer. J Thorac Oncol 2008;3:745-750.
    • (2008) J Thorac Oncol , vol.3 , pp. 745-750
    • Baas, P.1    Szczesna, A.2    Albert, I.3
  • 34
    • 70249101823 scopus 로고    scopus 로고
    • Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer
    • Borghaei H, Alpaugh K, Hedlund G et al. Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer. J Clin Oncol 2009;27:4116-4123.
    • (2009) J Clin Oncol , vol.27 , pp. 4116-4123
    • Borghaei, H.1    Alpaugh, K.2    Hedlund, G.3
  • 35
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data
    • Margolin K, Gordon MS, Holmgren E et al. Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data. J Clin Oncol 2001;19: 851-856.
    • (2001) J Clin Oncol , vol.19 , pp. 851-856
    • Margolin, K.1    Gordon, M.S.2    Holmgren, E.3
  • 36
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001;19:843-850.
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 37
    • 77950491674 scopus 로고    scopus 로고
    • Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-smallcell lung cancer
    • Haura EB, Tanvetyanon T, Chiappori A et al. Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-smallcell lung cancer. J Clin Oncol 2010;28:1387-1394.
    • (2010) J Clin Oncol , vol.28 , pp. 1387-1394
    • Haura, E.B.1    Tanvetyanon, T.2    Chiappori, A.3
  • 38
    • 33144484457 scopus 로고    scopus 로고
    • Multicenter phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer
    • Thienelt CD, Bunn PA Jr, Hanna N et al. Multicenter phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer. J Clin Oncol 2005;23:8786-8793.
    • (2005) J Clin Oncol , vol.23 , pp. 8786-8793
    • Thienelt, C.D.1    Bunn Jr., P.A.2    Hanna, N.3
  • 39
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller JH, Harrington D, Belani CP et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002; 346:92-98.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 40
    • 0036843105 scopus 로고    scopus 로고
    • Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer
    • Scagliotti GV, De Marinis F, Rinaldi M et al. Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer. J Clin Oncol 2002;20:4285-4291.
    • (2002) J Clin Oncol , vol.20 , pp. 4285-4291
    • Scagliotti, G.V.1    de Marinis, F.2    Rinaldi, M.3
  • 41
    • 0042413836 scopus 로고    scopus 로고
    • Randomized, multinational, phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: The TAX 326 study group
    • Fossella F, Pereira JR, von Pawel J et al. Randomized, multinational, phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: The TAX 326 study group. J Clin Oncol 2003;21:3016-3024.
    • (2003) J Clin Oncol , vol.21 , pp. 3016-3024
    • Fossella, F.1    Pereira, J.R.2    von Pawel, J.3
  • 42
    • 0035397994 scopus 로고    scopus 로고
    • Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: A Southwest Oncology Group trial
    • Kelly K, Crowley J, Bunn PA Jr et al. Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: A Southwest Oncology Group trial. J Clin Oncol 2001;19:3210-3218.
    • (2001) J Clin Oncol , vol.19 , pp. 3210-3218
    • Kelly, K.1    Crowley, J.2    Bunn Jr., P.A.3
  • 43
    • 40849111655 scopus 로고    scopus 로고
    • Clinical outcome and prognostic factors for patients treated within the context of a phase I study: The Royal Marsden Hospital experience
    • Arkenau HT, Olmos D, Ang JE et al. Clinical outcome and prognostic factors for patients treated within the context of a phase I study: The Royal Marsden Hospital experience. Br J Cancer 2008;98:1029-1033.
    • (2008) Br J Cancer , vol.98 , pp. 1029-1033
    • Arkenau, H.T.1    Olmos, D.2    Ang, J.E.3
  • 44
    • 61449180271 scopus 로고    scopus 로고
    • Survival of patients in a phase 1 clinic: The M. D. Anderson Cancer Center experience
    • Wheler J, Tsimberidou AM, Hong D et al. Survival of patients in a phase 1 clinic: The M. D. Anderson Cancer Center experience. Cancer 2009;115: 1091-1099.
    • (2009) Cancer , vol.115 , pp. 1091-1099
    • Wheler, J.1    Tsimberidou, A.M.2    Hong, D.3
  • 45
    • 70449090354 scopus 로고    scopus 로고
    • Phase I clinical trials in 56 patients with thyroid cancer: The M. D. Anderson cancer center experience
    • Tsimberidou AM, Vaklavas C, Wen S et al. Phase I clinical trials in 56 patients with thyroid cancer: The M. D. Anderson Cancer Center experience. J Clin Endocrinol Metab 2009;94:4423-4432.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4423-4432
    • Tsimberidou, A.M.1    Vaklavas, C.2    Wen, S.3
  • 46
    • 0034013999 scopus 로고    scopus 로고
    • Multivariable analysis of prognostic factors for toxicity and survival for patients enrolled in phase I clinical trials
    • Bachelot T, Ray-Coquard I, Catimel G et al. Multivariable analysis of prognostic factors for toxicity and survival for patients enrolled in phase I clinical trials. Ann Oncol 2000;11:151-156.
    • (2000) Ann Oncol , vol.11 , pp. 151-156
    • Bachelot, T.1    Ray-Coquard, I.2    Catimel, G.3
  • 47
    • 0242266499 scopus 로고    scopus 로고
    • Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents
    • Han C, Braybrooke JP, Deplanque G et al. Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents. Br J Cancer 2003;89:1166-1171.
    • (2003) Br J Cancer , vol.89 , pp. 1166-1171
    • Han, C.1    Braybrooke, J.P.2    Deplanque, G.3
  • 48
    • 77955115663 scopus 로고    scopus 로고
    • Patients with advanced head and neck cancers have similar progression-free survival on phase I trials and their last food and drug administration-approved treatment
    • Garrido-Laguna I, Janku F, Falchook GS et al. Patients with advanced head and neck cancers have similar progression-free survival on phase I trials and their last food and drug administration-approved treatment. Clin Cancer Res 2010;16:4031-4037.
    • (2010) Clin Cancer Res , vol.16 , pp. 4031-4037
    • Garrido-Laguna, I.1    Janku, F.2    Falchook, G.S.3
  • 49
    • 66749124176 scopus 로고    scopus 로고
    • Prospective validation of a prognostic score to improve patient selection for oncology phase I trials
    • Arkenau HT, Barriuso J, Olmos D et al. Prospective validation of a prognostic score to improve patient selection for oncology phase I trials. J Clin Oncol 2009;27:2692-2696.
    • (2009) J Clin Oncol , vol.27 , pp. 2692-2696
    • Arkenau, H.T.1    Barriuso, J.2    Olmos, D.3
  • 50
    • 7244243743 scopus 로고    scopus 로고
    • Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials
    • Roberts TG Jr, Goulart BH, Squitieri L et al. Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials. JAMA 2004; 292:2130-2140.
    • (2004) JAMA , vol.292 , pp. 2130-2140
    • Roberts Jr., T.G.1    Goulart, B.H.2    Squitieri, L.3
  • 51
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 52
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-819.
    • (2010) N Engl J Med , vol.363 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 53
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med;363:1693-703.
    • N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 54
    • 79960042770 scopus 로고    scopus 로고
    • Targeted therapy in non-small-cell lung cancer-is it becoming a reality?
    • Janku F, Stewart DJ, Kurzrock R. Targeted therapy in non-small-cell lung cancer-is it becoming a reality? Nat Rev Clin Oncol 2010;7:401-414
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 401-414
    • Janku, F.1    Stewart, D.J.2    Kurzrock, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.