Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation

Angewandte Chemie - International Edition

Volumn 50, Issue 14, 2011, Pages 3164-3167

  Subtelny, Alexander O ^a,c   Hartman, Matthew C T ^a,b   Szostak, Jack W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

amino acids; codon anticodon recognition; directed evolution; peptidomimetics; translational fidelity

Indexed keywords

AMINO ACID INCORPORATION; CELL-FREE; CODON-ANTICODON RECOGNITION; DIRECTED EVOLUTION; IN-VITRO; NONRIBOSOMAL PEPTIDE; PEPTIDOMIMETICS; TRANSLATIONAL FIDELITY;

OPTIMIZATION; PEPTIDES;

AMINO ACIDS;

AMINO ACID; PEPTIDE; TRANSFER RNA;

ARTICLE; CHEMISTRY; CODON; GENETICS; MASS SPECTROMETRY; METABOLISM; PROTEIN SYNTHESIS;

AMINO ACIDS; CODON; PEPTIDES; PROTEIN BIOSYNTHESIS; RNA, TRANSFER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 79953004613     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201007686     Document Type: Article

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