Constancy and variability in the output of a central pattern generator

Journal of Neuroscience

Volumn 31, Issue 12, 2011, Pages 4663-4674

  Norris, Brian J ^a,b   Wenning, Angela ^a   Wright, Terrence Michael ^a   Calabrese, Ronald L ^a  

^a EMORY UNIVERSITY   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEART BEAT; INTERNEURON; INTRACELLULAR RECORDING; LEECH; MOTONEURON; MOTOR NERVE CONDUCTION; NERVE CELL STIMULATION; NONHUMAN; PATTERN STIMULATION; PRIORITY JOURNAL; SPECIES DIFFERENCE; SPIKE WAVE; SYNAPTIC TRANSMISSION; ALGORITHM; ANIMAL; DRIVE; ELECTROPHYSIOLOGY; EXTRACELLULAR SPACE; HEART; INNERVATION; NERVE CELL NETWORK; NERVE CONDUCTION; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; STATISTICAL ANALYSIS;

ALGORITHMS; ANIMALS; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGICAL PHENOMENA; EXTRACELLULAR SPACE; HEART; INSTINCT; INTERNEURONS; LEECHES; MOTOR NEURONS; NERVE NET; NEURAL CONDUCTION; PATCH-CLAMP TECHNIQUES;

EID: 79953003469     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5072-10.2011     Document Type: Article

References (23)

1. Angstadt JD, Calabrese RL (1991) Calcium currents and graded synaptic transmission between heart interneurons of the leech. J Neurosci 11:746-759.
2. García PS, Wright TM, Cunningham IR, Calabrese RL (2008) Using a model to assess the role of the spatiotemporal pattern of inhibitory input and intrasegmental electrical coupling in the intersegmental and side-toside coordination of motor neurons by the leech heartbeat central pattern generator. J Neurophysiol 100:1354-1371.
3. Goaillard JM, Taylor AL, Schulz DJ, Marder E (2009) Functional consequences of animal-to-animal variation in circuit parameters. Nat Neurosci 12:1424-1430.
4. Grashow R, Brookings T, Marder E (2010) Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions. J Neurosci 30:9145-9156.
5. Günay C, Edgerton JR, Jaeger D (2008) Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. J Neurosci 28:7476-7491.
6. Kristan WB Jr, Calabrese RL, Friesen WO (2005) Neuronal control of leech behavior. Prog Neurobiol 76:279-327. (Pubitemid 41613881)
7. Maranto AR, Calabrese RL (1984) Neural control of the hearts in the leech, Hirudo medicinalis. I. Anatomy, electrical coupling, and innervation of the hearts. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 154:367-380.
8. Marder E, Calabrese RL (1996) Principles of rhythmic motor pattern generation. Physiol Rev 76:687-717. (Pubitemid 26286076)
9. Marder E, Goaillard JM (2006) Variability, compensation and homeostasis in neuron and network function. Nat Rev Neurosci 7:563-574. (Pubitemid 43995432)
10. Marder E, Bucher D, Schulz DJ, Taylor AL (2005) Invertebrate central pattern generation moves along. Curr Biol 15:R685-R699. (Pubitemid 41219586)
11. Marder E, Tobin AE, Grashow R (2007) How tightly tuned are network parameters? Insight from computational and experimental studies in small rhythmic motor networks. Prog Brain Res 165:193-200. (Pubitemid 47516725)
12. Norris BJ, Weaver AL, Morris LG, Wenning A, García PA, Calabrese RL (2006) A central pattern generator producing alternative outputs: temporal pattern of premotor activity. J Neurophysiol 96:309-326. (Pubitemid 44015362)
13. Norris BJ, Weaver AL, Wenning A, García PS, Calabrese RL (2007a) A central pattern generator producing alternative outputs: pattern, strength, and dynamics of premotor synaptic input to leech heart motor neurons. J Neurophysiol 98:2992-3005. (Pubitemid 350127957)
14. Norris BJ, Weaver AL, Wenning A, García PS, Calabrese RL (2007b) A central pattern generator producing alternative outputs: phase relations of leech heart motor neurons with respect to premotor synaptic input. J Neurophysiol 98:2983-2991. (Pubitemid 350127956)
15. Olypher AV, Calabrese RL (2007) Using constraints on neuronal activity to reveal compensatory changes in neuronal parameters. J Neurophysiol 98:3749-3758.
16. Olypher AV, Calabrese RL (2009) How does maintenance of network activity depend on endogenous dynamics of isolated neurons? Neural Comput 21:1665-1682.
17. Prinz AA (2007) Computational exploration of neuron and neural network models in neurobiology. Methods Mol Biol 401:167-179.
18. Prinz AA, Bucher D, Marder E (2004) Similar network activity from disparate circuit parameters. Nat Neurosci 7:1345-1352. (Pubitemid 41057757)
19. Schulz DJ, Goaillard JM, Marder E (2006) Variable channel expression in identified single and electrically coupled neurons in different animals. Nat Neurosci 9:356-362. (Pubitemid 43290965)
20. Schulz DJ, Goaillard JM, Marder EE (2007) Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression. Proc Natl Acad Sci U S A 104:13187-13191. (Pubitemid 351737614)
21. Tobin AE, Cruz-Bermúdez ND, Marder E, Schulz DJ (2009) Correlations in ion channel mRNA in rhythmically active neurons. PLoS One 4:e6742.
22. Wenning A, Cymbalyuk GS, Calabrese RL (2004a) Heartbeat control in leeches. I. Constriction pattern and neural modulation of blood pressure in intact animals. J Neurophysiol 91:382-396. (Pubitemid 38084382)
23. Wenning A, Hill AA, Calabrese RL (2004b) Heartbeat control in leeches. II. Fictive motor pattern. J Neurophysiol 91:397-409. (Pubitemid 38084383)