Expression of podoplanin in thymoma: Its correlation with tumor invasion, nodal metastasis, and poor clinical outcome

Human Pathology

Volumn 42, Issue 4, 2011, Pages 533-540

  Tateyama, Hisashi ^a   Sugiura, Hiroshi ^a   Yamatani, Chihiro ^a   Yano, Motoki ^b  

^a Kasugai Municipal Hospital   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

D2 40; Immunohistochemistry; Lymph node metastasis; Podoplanin; Thymoma

Indexed keywords

MONOCLONAL ANTIBODY D2-40; PODOPLANIN;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER INVASION; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; THYMOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; THYMOMA; THYMUS NEOPLASMS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 79952989866     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.08.012     Document Type: Article

References (33)

1. Quintanilla-Martinez L., Wilkins E.W. Jr, Ferry J.A., and Harris N.L. Thymoma-morphologic subclassification correlates with invasiveness and immunohistologic features: a study of 122 cases Hum Pathol 24 1993 958 969 (Pubitemid 23281531)
2. Travis W.D., Brambilla E., Muller-Hermelink H.K., and Harris C.C. Pathology and genetics of tumors of the lung, pleura, thymus and heart. World Health Organization classification of tumours 2004 IARC Press Lyon
3. Shimosato Y., and Mukai K. Tumors of the mediastinum. Atlas of tumor pathology, 3rd series, fascicle 21 1997 Armed Forces Institute of Pathology Washington DC
4. Rosai J., and Sobin L.H. Histological typing of tumors of the thymus. World Health Organization international histologic classification of tumors 2nd ed. 1999 Springer Berlin
5. Quintanilla-Martinez L., Wilkins E.W. Jr, Choi N., Efird J., Hug E., and Harris N.L. Thymoma: histologic subclassification is an independent prognostic factor Cancer 74 1994 606 617 (Pubitemid 24217624)
6. Blumberg D., Port J.L., and Weksler B. Thymoma: a multivariate analysis of factors predicting survival Ann Thorac Surg 60 1995 908 914
7. Okumura M., Ohta M., and Tateyama H. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients Cancer 94 2002 624 632 (Pubitemid 34132289)
8. Chen G., Marx A., and Wen-Hu C. New WHO histologic classification predicts prognosis of thymic epithelial tumors Cancer 95 2002 420 429
9. Nomori H., Watanabe K., and Ohtsuka T. Pulmonary metastasis 12 years after resection of thymoma with microscopic capsule invasion Jpn J Clin Oncol 34 2004 630 633 (Pubitemid 40662720)
10. Gamboa E.O., Sawhney V., Lanoy R.S., and Haller N.A. Widespread metastases after resection of noninvasive thymoma J Clin Oncol 26 2008 1752 1755
11. Kahn H.J., and Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors Lab Invest 82 2002 1255 1257 (Pubitemid 35014860)
12. Schacht V., Dadras S.S., Johnson L.A., Jackson D.G., Hong Y.K., and Detmar M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinoma and germ cell tumors Am J Pathol 166 2005 913 921 (Pubitemid 40315647)
13. Marks A., Sutherland D.R., and Bailey D. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumors Br J Cancer 80 1999 569 578 (Pubitemid 29213215)
14. Renyi-Vamos F., Tovari J., and Fillinger J. Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer Clin Cancer Res 11 2005 7344 7353 (Pubitemid 41507693)
15. Gombos Z., Xu X., Chu C.S., Zhang P.J., and Acs G. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix Clin Cancer Res 11 2005 8364 8371 (Pubitemid 41746949)
16. Roma A.A., Magi-Galluzzi C., Kral M.A., Jin T.T., Klein E.A., and Zhou M. Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma Mod Pathol 19 2006 392 398 (Pubitemid 43276993)
17. Van den Eynden G.G., Van der Auwera I., and Van Laere S.J. Distinguishing blood and lymph vessel invasion in breast cancer: a prospective immunohistochemical study Br J Cancer 94 2006 1643 1649 (Pubitemid 43924927)
18. Saad R.S., Kordunsky L., Liu Y.L., Denning K.L., Kandil H.A., and Silverman J.F. Lymphatic microvessel density as prognostic marker in colorectal cancer Mod Pathol 19 2006 1317 1323 (Pubitemid 44423078)
19. Kato Y., Kaneko M., Sata M., Fujita N., Tsuruo T., and Osawa M. Enhanced expression of aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma Tumor Biol 26 2005 195 200 (Pubitemid 41379745)
20. Yuan P., Temam S., and El-Naggar A. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome Cancer 107 2006 563 569 (Pubitemid 44107217)
21. Masaoka A., Monden Y., Nakahara K., and Tanioka T. Follow-up study of thymomas with special reference to their clinical stages Cancer 48 1981 2485 2492 (Pubitemid 12228012)
22. Tateyama H., Mizuno T., and Tada T. Thymic epithelial tumors: evaluation of malignant grade by quantification of proliferating cell nuclear antigen and nucleolar organizer regions Virchows Arch A Pathol Anat 422 1993 265 269 (Pubitemid 23169370)
23. Tateyama H., Eimoto T., and Tada T. p53 protein expression and p53 gene mutation in thymic epithelial tumors: an immunohistochemical and DNA sequencing study Am J Clin Pathol 104 1995 375 381
24. Pich A., Chiarle R., and Chiusa L. Long-term survival of thymoma patients by histologic pattern and proliferative activity Am J Surg Pathol 19 1995 918 926
25. Yang W.I., Efird J.T., Quintanilla-Martinez L., Choi N., and Harris N.L. Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies Hum Pathol 27 1996 70 76 (Pubitemid 26015583)
26. Chen F.F., Yan J.J., Jin Y.T., and Su I.J. Detection of bcl-2 and p53 in thymoma: expression of bcl-2 as a reliable marker of tumor aggressiveness Hum Pathol 27 1996 1089 1092
27. Tateyama H., Eimoto T., Tada T., Inagaki H., Hattori H., and Takino H. Apoptosis, bcl-2 protein, and Fas antigen in thymic epithelial tumors Mod Pathol 10 1997 983 991 (Pubitemid 27471118)
28. Takahashi E., Tateyama H., and Akatsu H. Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors Hum Pathol 34 2003 1253 1258 (Pubitemid 38018138)
29. Breiteneder-Geleff S., Matsui K., and Soleiman A. Podoplanin, novel 43-kD membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis Am J Pathol 151 1997 1141 1152 (Pubitemid 27424324)
30. Schacht V., Ramirez M.I., and Hong Y.K. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema EMBO J 22 2003 3546 3556 (Pubitemid 36898332)
31. Kunita A., Kashima T.G., and Morishita Y. The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis Am J Pathol 170 2007 1337 1347 (Pubitemid 47339340)
32. Murphy G.F. Histology of the skin DE Elder, R Elenitsas, BL Johnson Jr. GF Murphy, Lever's histopathology of the skin 9th ed. 2005 Lippincott Williams & Wilkins Philadelphia 9 58
33. Blackburn C.C., Manley N.R., Palmer D.B., Boyd R.L., Anderson G., and Ritter M.A. One for all and all for one: thymic epithelial stem cells and regeneration Trends Immunol 23 2002 391 395 (Pubitemid 34804634)