Pharmacokinetic/pharmacodynamic evaluation of amoxicillin, amoxicillin/clavulanate and ceftriaxone in the treatment of paediatric acute otitis media in Spain

Enfermedades Infecciosas y Microbiologia Clinica

Volumn 29, Issue 3, 2011, Pages 167-173

  Isla, Arantxazu ^a   Trocóniz, Iñaki F ^b   Canut, Andrés ^c   Labora, Alicia ^c   Martín Herrero, José Emilio ^d   Pedraz, José Luis ^a   Gascón, Alicia R ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

^c HOSPITAL TXAGORRITXU   (Spain)

^d GLAXOSMITHKLINE   (Spain)

Author keywords

Acute otitis media; Amoxicillin; Ceftriaxone; Children; Haemophilus influenzae; Streptococcus pneumoniae

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; CEFTRIAXONE;

ACUTE OTITIS MEDIA; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; DRUG CONCENTRATION; DRUG MEGADOSE; DRUG RESPONSE; HAEMOPHILUS INFLUENZAE; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEDIATRICS; SINGLE DRUG DOSE; SPAIN; STREPTOCOCCUS PNEUMONIAE;

AMOXICILLIN; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; BETA-LACTAM RESISTANCE; CEFTRIAXONE; CHILD; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; MICROBIAL SENSITIVITY TESTS; MONTE CARLO METHOD; OTITIS MEDIA; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE;

EID: 79952987200     PISSN: 0213005X     EISSN: 15781852     Source Type: Journal    
DOI: 10.1016/j.eimc.2010.05.008     Document Type: Article

References (20)

1. J.A. Finkelstein, J.P. Metlay, R.L. Davis, S.L. Rifas-Shiman, S.F. Dowell, and R. Platt Antimicrobial use in defined populations of infants and young children Arch Pediatr Adolesc Med 154 2000 395 400 (Pubitemid 30198490)
2. G. Solis, C. Ochoa, and M.C. Perez The variability and appropriateness of the antibiotic prescription of acute otitis media in childhood. The Spanish Study Group for Antibiotic Treatments Int J Pediatr Otorhinolaryngol 56 2000 175 184 (Pubitemid 32008253)
3. G.L. Drusano, and W.A. Craig Relevance of pharmacokinetics and pharmacodynamics in the selection of antibiotics for respiratory tract infections J Chemother 9 Suppl 3 1997 38 44 (Pubitemid 27294747)
4. R. Dagan The use of pharmacokinetic/pharmacodynamic principles to predict clinical outcome in paediatric acute otitis media Int J Antimicrob Agents 30 Suppl 2 2007 127 130 (Pubitemid 350101125)
5. I. Beobide, A. Canut, A.R. Gascón, A. Isla, C. García-Rey, and I. De la Maza Evaluation of antimicrobial treatments in children with acute otitis media in Spain: a pharmacokinetic-pharmacodynamic (PK/PD) approach J Chemother 17 2005 628 635 (Pubitemid 43097750)
6. E. Pérez-Trallero, C. García-de-la-Fuente, C. García-Rey, F. Baquero, L. Aguilar, and R. Dal-Ré Geographical and ecological analysis of resistance, coresistance, and coupled resistance to antimicrobials in respiratory pathogenic bacteria in Spain Antimicrob Agents Chemother 49 2005 1965 1972 (Pubitemid 40631613)
7. Susceptibility to antimicrobials agents used in the community in Spain (SAUCE 3 Project). GlaxoSmithKline, S.A. 2004. (Data on file).
8. D.M. Canafax, Z. Yuan, T. Chonmaitree, K. Deka, H.Q. Russlie, and G.S. Giebink Amoxicillin middle ear fluid penetration and pharmacokinetics in children with acute otitis media Pediatr Infect Dis J 17 1998 149 156 (Pubitemid 28096015)
9. J.L. Blumer, M.D. Reed, E.L. Kaplan, and G.L. Drusano Explaining the poor bacteriologic eradication rate of single-dose ceftriaxone in group a streptococcal tonsillopharyngitis: a reverse engineering solution using pharmacodynamic modeling Pediatrics 116 2005 927 932 (Pubitemid 44542820)
10. G.L. Drusano, S.L. Preston, C. Hardalo, R. Hare, C. Banfield, D. Andes, O. Vesga, and W.A. Craig Use of preclinical data for selection of a phase II/III dose for evernimicin and identification of a preclinical MIC breakpoint Antimicrob Agents Chemother. 45 2001 13 22 (Pubitemid 32039087)
11. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Nineteenth Informational Supplement M100-S19. CLSI, Wayne, PA, USA, 2009.
12. W.A. Craig, and D. Andes Pharmacokinetics and pharmacodynamics of antibiotics in otitis media Pediatr Infect Dis J 15 1996 255 259 (Pubitemid 26098477)
13. T. Gudnason, F. Gudbrandsson, F. Barsanti, and K.G. Kristinsson Penetration of ceftriaxone into the middle ear fluid of children Pediatr Infect Dis J 17 1998 258 260 (Pubitemid 28146075)
14. C.J. Harrison Using antibiotic concentrations in middle ear fluid to predict potential clinical efficacy Pediatr Infect Dis J 16 Suppl 2 1997 S12 S16
15. F. Scaglione, D. Caronzolo, J.P. Pintucci, and F. Fraschini Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media Antimicrob Agents Chemother 47 2003 2987 2989 (Pubitemid 37040283)
16. J. Turnidge, and D.L. Paterson Setting and revising antibacterial susceptibility breakpoints Clin Microbiol Infect Dis 20 2007 391 408 (Pubitemid 47175010)
17. J.S. Bradley, M.N. Dudley, and G.L. Drusano Predicting efficacy of antiinfectives with pharmacodynamics and Monte Carlo simulation Pediatr Infect Dis J 22 2003 982 992
18. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media. Diagnosis and management of acute otitis media Pediatrics 113 2004 1451 1465
19. R.M. Fallon, J.L. Kuti, G.V. Doern, J.E. Girotto, and D.P. Nicolau Pharmacodynamic target attainment of oral beta-lactams for the empiric treatment of acute otitis media in children Paediatr Drugs. 10 2008 329 335
20. E. Leibovitz, L. Piglansky, S. Raiz, J. Press, A. Leiberman, and R. Dagan Bacteriologic and clinical efficacy of one day vs. three day intramuscular ceftriaxone for treatment of nonresponsive acute otitis media in children Pediatr Infect Dis J 19 2000 1040 1045