Ionotropically cross-linked pH-sensitive IPN hydrogel matrices as potential carriers for intestine-specific oral delivery of protein drugs

Drug Development and Industrial Pharmacy

Volumn 37, Issue 2, 2011, Pages 121-130

  El Sherbiny, Ibrahim M ^a,b   Salama, Ahmed ^c   Sarhan, Ali A ^a  

^a Mansoura University   (Egypt)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Alginate; carboxymethyl cellulose; in vitro release; IPN; oral delivery; pH sensitivity; protein drugs

Indexed keywords

ACRYLIC ACID DERIVATIVE; ALGINIC ACID; BOVINE SERUM ALBUMIN; CALCIUM CHLORIDE; CALCIUM ION; CARBOXYMETHYLCELLULOSE; COPOLYMER; DRUG CARRIER; SODIUM ACRYLATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG RELEASE; GELATION; HYDROGEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTERPENETRATING POLYMERIC NETWORK; INTESTINE FLUID; ORAL DRUG ADMINISTRATION; PH; POLYMERIZATION; SCANNING ELECTRON MICROSCOPY; STOMACH JUICE; TEMPERATURE; X RAY DIFFRACTION;

ACRYLATES; ADMINISTRATION, ORAL; CALCIUM; CARBOXYMETHYLCELLULOSE SODIUM; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GASTRIC JUICE; HYDROGELS; HYDROGEN-ION CONCENTRATION; INTESTINAL SECRETIONS; INTESTINE, SMALL; MICROSCOPY, ELECTRON, SCANNING; SERUM ALBUMIN, BOVINE; TIME FACTORS;

EID: 79952982221     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.495754     Document Type: Article

References (23)

1. El-Sherbiny IM, Abdel-Bary EM, Harding DRK. (2010). Preparation and in vitro evaluation of new pH-sensitive hydrogel beads for oral delivery of protein drugs. J Appl Polym Sci, 115, 2828-37.
2. Ramadas M, Paul W, Dileep KJ, Anitha Y, Sharma CP. (2000). Lipoinsulin encapsulated alginate-chitosan capsules: Intestinal delivery in diabetic rats. J Microencapsul, 17, 405-11. (Pubitemid 30420823)
3. Dolatabadi-Farahani T, Vasheghani-Farahani E, Mirzadeh H. (2006). Swelling behaviour of alginate-N,O-carboxymethyl chitosan gel beads coated by chitosan. Iran Polym J, 15, 405-15. (Pubitemid 44186026)
4. El-Sherbiny IM. (2010). Enhanced pH-responsive carrier system based on alginate and chemically modified carboxymethyl chitosan for oral delivery of protein drugs: Preparation and in-vitro assessment. Carbohydr Polym, 80, 1125-36.
5. Imren D, Gumusderelioglu M, Guner A. (2010). In vitro release kinetics of bovine serum albumin from highly swellable dextran hydrogels. J Appl Polym Sci, 115, 740-7.
6. Liu Z, Jiao Y, Zhang Z. (2007). Calcium-carboxymethyl chitosan hydrogel beads for protein drug delivery system. J Appl Polym Sci, 103, 3164-68. (Pubitemid 46345606)
7. Mi FL, Liang HF, Wu YC, Lin YS, Yang TF, Sung HW. (2005). pHsensitive behavior of two-component hydrogels composed of N,O-carboxymethyl chitosan and alginate. J Biomater Sci Polym Ed, 16, 1333-45.
8. Rekha MR, Sharma CP. (2008). Phthalyl chitosan-poly(ethylene oxide) semi-interpenetrating polymer network microparticles for oral protein delivery: An in vitro characterization. J Appl Polym Sci, 110, 2787-95.
9. Ju HK, Kim SY, Kim SJ, Lee YM. (2002). pH/temperatureresponsive semi-IPN hydrogels composed of alginate and poly(N-isopropylacrylamide). J Appl Polym Sci, 83, 1128-39. (Pubitemid 34011356)
10. Zhang K, Luo Y, Li Z. (2007). Synthesis and characterization of a pH- and ionic strength-responsive hydrogel. Soft Mater, 5, 183-95. (Pubitemid 47624561)
11. Decho AW. (1999). Imaging an alginate polymer gel matrix using atomic force microscopy. Carbohydr Res, 315, 330-3.
12. Hari PR, Chandy T, Sharma CP. (1996). Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. JMicroencapsul, 13, 319-29. (Pubitemid 26149541)
13. Murata Y, Kodama Y, Isobe T, Kofuji K, Kawashima S. (2009). Drug release profile from calcium-induced alginate-phosphate composite gel beads. Int J Polym Sci, 2009, 1-4.
14. Vandenberg GW, Drolet C, Scott SL, de la Noue J. (2001). Factors affecting protein release from alginate-chitosan coacervate microcapsules during production and gastric/intestinal simulation. J Control Release, 77, 297-307. (Pubitemid 33145481)
15. Lin YH, Liang HF, Chung CK, Chen MC, Sung HW. (2005). Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs. Biomaterials, 26, 2105-13.
16. Kim SJ, Park SJ, Kim SI. (2003). Swelling behavior of interpenetrating polymer network hydrogels composed of poly-(vinyl alcohol) and chitosan. React Funct Polym, 55, 53-9.
17. Kurita K. (2001). Controlled functionalization of the polysaccharide chitin. Prog Polym Sci, 26, 1921-71. (Pubitemid 33089088)
18. Majewicz TG, Podlas TJ. (1966). Encyclopedia of chemical technology, 4th ed. New York: Wiley.
19. Ameye D, Voorspoels J, Foreman P, Tsai J, Richardson P, Geresh S, et al. (2001). Trypsin inhibition, calcium and zinc ion binding of starch-g- poly(acrylic acid) copolymers and starch/ poly(acrylic acid) mixtures for peroral peptide drug delivery. J Control Release, 75, 357-64. (Pubitemid 32727265)
20. Luessen HL, Bochard G, Verhoef JC, Lehr CM, de Boer GA, Junginger HE. (1995). Mucoadhesive polymers in peroral peptide drug delivery. II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin. Pharm Res, 12, 1293-98.
21. El-Sherbiny IM, Salama A, Sarhan AA. (2009). Grafting study and antifungal activity of a carboxymethyl cellulose derivative. Int J Polym Mater, 58, 453-67.
22. Shantha KL, Bala U, Panduranga RK. (1995). Tailor-made chitosans for drug delivery. Eur Polym J, 31, 377-82.
23. Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-54.