Bioenhancers: Revolutionary concept to market

Journal of Ayurveda and Integrative Medicine

Volumn 1, Issue 2, 2010, Pages 96-99

  Atal, Navin ^a   Bedi, K L ^b  

^a Pushpanjali Medical Center   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Bioenhancer; Piper longum; piperine

Indexed keywords

AYURVEDIC DRUG; BIOENHANCER AGENT; ISONIAZID; PIPERINE; RIFAMPICIN; RISORINE; UNCLASSIFIED DRUG;

ARTICLE; AYURVEDA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG FORMULATION; DRUG METABOLISM; DRUG POTENTIATION; DRUG RESEARCH; ENZYME ACTIVITY; GLUCURONIDATION; HEALTH CARE COST; HUMAN; INTEGRATIVE MEDICINE; MEDICAL RESEARCH; NANOTECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 79952976736     PISSN: 09759476     EISSN: 09762809     Source Type: Journal    
DOI: 10.4103/0975-9476.65073     Document Type: Article

References (20)

1. Patwardhan B, Mashelkar RA. Traditional medicine-inspired approaches to drug discovery and development: can Ayurveda show a way forward? Drug Discov Today 2009;14:804-11.
2. Atal CK. A breakthrough in drug bioavailability-a clue from age old wisdom of Ayurveda. I.D.M.A. Bulletin 1979;10:483-4.
3. Johri RK, Zutshi U. An Ayurvedic formulation 'Trikatu' and its constituents. J Ethnopharmacol 1992;37:85-91.
4. Zutshi RK, Singh R, Zutshi U, Johri RK, Atal CK. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc Physicians India 1985;33:223-4.
5. Shaikh J, Ankola DD, Beniwal V, Singh D, Kumar MN. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 2009:37;223-30.
6. Atal CK, Zutshi U, Rao PG. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. J Ethnopharmacol 1981;4:229-32. (Pubitemid 11014202)
7. Bhojwani HR, Aggarwal OP. A new bioavailability enhancing technology, Millennium RandD management conference leveraging research and technology, CSIR (7-8 Dec, 2000). 2000. 30-1
8. Bajad S, Bedi KL, Singla AK, Johri RK. Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med 2001;67;176-9. (Pubitemid 32234689)
9. Sangwan PL, Koul JL, Koul S, Reddy MV, Thota N, KhanIA, et al. Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors. Bioorg Med Chem. 2008 Nov 15;16(22):9847-57.
10. Kumar A, Khan IA, Koul S, Koul JL, Taneja SC, Ali I, et al. Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus. J Antimicrob Chemother 2008;61:1270-6. (Pubitemid 351753593)
11. Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. J Pharmacol Exp Ther 1985;232:258-62. (Pubitemid 15193683)
12. Singh J, Dubey RK, Atal CK. Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content. J Pharmacol Exp Ther 1986;236;488-93. (Pubitemid 16184247)
13. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. (Pubitemid 34787231)
14. Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption-An active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol 1998;36;46-50. (Pubitemid 28063097)
15. Bajad S, Bedi KL, Singla AK, Johri RK. Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med 2001;67:176-9. (Pubitemid 32234689)
16. Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41:615-7.
17. Khan IA, Mirza ZM, Kumar A, Verma V, Qazi GN. Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus. Antimicrob Agents Chemother. 2006 Feb;50(2):810-2. (Pubitemid 43191009)
18. Khan IA, Mirza ZM, Kumar A, Verma V, Qazi GN. "Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus0". Antimicrob Agents Chemother 2006;50:810-2. (Pubitemid 43191009)
19. Sangwan PL, Koul JL, Koul S, Reddy MV, Thota N, Khan IA, et al. "Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors". Bioorg Med Chem 2008;16:9847-57.
20. Thota N, Koul S, Reddy MV, Sangwan PL, Khan IA, Kumar A, et al. "Citral derived amides as potent bacterial NorA efflux pump inhibitors". Bioorg Med Chem 2008;16:6535-43. (Pubitemid 351794252)