Psychiatric outcomes in young children with a history of institutionalization

Harvard Review of Psychiatry

Volumn 19, Issue 1, 2011, Pages 15-24

  Bos, Karen ^a,b   Zeanah, Charles H ^c   Fox, Nathan A ^d   Drury, Stacy S ^c   McLaughlin, Katie A ^e   Nelson, Charles A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Child neglect; emotional and social development; foster care; institutionalized children

Indexed keywords

ARTICLE; BRAIN DEVELOPMENT; CHILD; EMOTION; EMOTIONAL ATTACHMENT; FOSTER CARE; GENETIC VARIABILITY; HUMAN; INSTITUTIONALIZATION; MENTAL HEALTH; MORBIDITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSYCHIATRY; SOCIAL ISOLATION; SYMPTOMATOLOGY;

CHILD ABUSE; CHILD, INSTITUTIONALIZED; CHILD, PRESCHOOL; DEVELOPMENTAL DISABILITIES; EARLY INTERVENTION (EDUCATION); EMOTIONS; FEMALE; FOSTER HOME CARE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; MALE; MENTAL DISORDERS; OBJECT ATTACHMENT; PSYCHOSOCIAL DEPRIVATION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REACTIVE ATTACHMENT DISORDER; ROMANIA; SEX FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 79952968801     PISSN: 10673229     EISSN: 14657309     Source Type: Journal    
DOI: 10.3109/10673229.2011.549773     Document Type: Article

References (45)

1. Egeland B, Sroufe LA, Erickson M. The developmental consequence of different patterns of maltreatment. Child Abuse Negl 1983;7:459-69.
2. Cicchetti D, Barnett D. Attachment organization in maltreated preschoolers. Dev Psychopathol 1991;4:397-411.
3. Widom CS, DuMont K, Czaja SJ. A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch Gen Psychiatry 2007;64:49-56. (Pubitemid 46041738)
4. Zeanah CH, Nelson CA, Fox NA, et al. Designing research to study the effects of institutionalization on brain and behavioral development: The Bucharest Early Intervention Project. Dev Psychopathol 2003;15:885-907. (Pubitemid 351480021)
5. MacLean K. The impact of institutionalization on child development. Dev Psychopathol 2003;15:853-84.
6. Colvert E, Rutter M, Beckett C, et al. Emotional difficulties in early adolescence following severe early deprivation: Findings from the English and Romanian adoptees study. Dev Psychopathol 2008;20:547-67. (Pubitemid 351584024)
7. Tizard B, Rees J. The effect of early institutional rearing on the behaviour problems and affectional relationships of four year old children. J Child Psychol Psychiatry 1975;16:61-73.
8. Chisholm K, Carter MC, Ames EW, Morison SJ. Attachment security and indiscriminately friendly behaviour in children adopted from Romanian orphanages. Dev Psychopathol 1995;7:283-94.
9. Hodges J, Tizard B. Social and family relationships of ex-institutional adolescents. J Child Psychol Psychiatry 1989;30:77-97.
10. Ellis BH, Fisher PA, Zaharie S. Predictors of disruptive behavior, developmental delays, anxiety, and affective symptomatology among institutionally reared Romanian children. J Am Acad Child Adolesc Psychiatry 2004;43:1283-92. (Pubitemid 39281669)
11. Rutter M, Kreppner J, Croft C, et al. Early adolescent outcomes of institutionally deprived and non-deprived adoptees. III. Quasi-autism. J Child Psychol Psychiatry 2007;48:1200-7. (Pubitemid 350256549)
12. Eluvathingal TJ, Chugani HT, Behen ME, et al. Abnormal brain connectivity in children after early severe socioemotional deprivation: A diffusion tensor imaging study. Pediatrics 2006;117:2093-100. (Pubitemid 46071255)
13. Wismer Fries AB, Ziegler TE, Kurian JR, Jacoris S, Pollak SD. Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. ProcNatl Acad Sci U S A 2005;102:17237-40. (Pubitemid 41692713)
14. Fries AB, Shirtcliff EA, Pollak SD. Neuroendocrine dysregulation following early social deprivation in children. Dev Psychobiol 2008;50:588-99.
15. Smyke AT, Zeanah CH, Fox NA, Nelson CA, Guthrie D. Placement in foster care enhances quality of attachment among young institutionalized children. Child Dev 2010;81:212-23.
16. Ainsworth MDS, Blehar MC, Waters E, Wall S. Patterns of attachment. Hillsdale, NJ: Erlbaum, 1978.
17. Green J, Goldwyn R. Annotation: Attachment disorganization and psychopathology: New findings in attachment research and their potential implications for developmental psychopathology in childhood. J Child Psychol Psychiatry 2002;43: 835-46. (Pubitemid 36939263)
18. Lyons-Ruth K, Bureau JF, Riley CD, Atlas-Corbett AF. Socially indiscriminate behavior in the Strange Situation: Convergent and discriminant validity in relation to caregiving risk, later behavior problems, and attachment insecurity. Dev Psychopathol 2009;21:355-72.
19. Zeanah CH, Smyke AT, Koga SF, Carlson E; Bucharest Early Intervention Project Core Group. Attachment in institutionalized and community children in Romania. Child Dev 2005;76:1015-28. (Pubitemid 41463538)
20. Smyke AT, Koga SF, Johnson DE, et al. The caregiving context in institution-reared and family-reared infants and toddlers. J Child Psychol Psychiatry 2007;48:210-8. (Pubitemid 46189944)
21. Smyke, AT, Zeanah CH, Egger HL. Timing effects on attachment and psychiatric morbidity: The Bucharest Early Intervention Project. Paper presented at a symposium at the Society for Research in Child Development, Denver, CO, April 2009.
22. Ghera MM, Marshall PJ, Fox NA, et al. The effects of foster care intervention on socially deprived institutionalized children's attention and positive affect: Results from the BEIP study. J Child Psychol Psychiatry 2009;50:246-53.
23. Egger HL, Erkanli A, Keeler G, Potts E, Walter BK, Angold A. Test-retest reliability of the Preschool Age Psychiatric Assessment (PAPA). J Am Acad Child Adolesc Psychiatry 2006;45:538-49.
24. Zeanah CH, Egger HL, Smyke AT, et al. Institutional rearing and psychiatric disorders in Romanian preschool children. Am J Psychiatry 2009;166:777-85.
25. Nelson CA 3rd, Zeanah CH, Fox NA, Marshall PJ, Smyke AT, Guthrie D. Cognitive recovery in socially deprived young children: The Bucharest Early Intervention Project. Science 2007;318:1937-40.
26. Rutter ML, Kreppner JM, O'Connor TG; English and Romanian Adoptees study team. Specificity and heterogeneity in children's responses to profound institutional privation. Br J Psychiatry 2001;179:97-103. (Pubitemid 32756490)
27. Caspi A, Sugden K, Moffitt T, et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-9. (Pubitemid 36877077)
28. Ritchie K, Jaussent I, Stewart R, et al. Association of adverse childhood environment with late-life depression. J Clin Psychiatry 2009;79:1281-8.
29. Xie P, KranzlerHR, Poling J, et al. Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. Arch Gen Psychiatry 2009;11:1201-9.
30. Stevens SE, Kumsta R, Kreppner JM, Brookes KJ, Rutter M, Sonuga-Barke EJ. Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene-environment interplay. Am J Med Genet B Neuropsychiatr Genet 2009;150B: 753-61.
31. Kumsta R, Stevens S, Brookes K, et al. 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: Evidence from the English and Romanian Adoptee (ERA) study. J Child Psychol Psychiatry 2010;51:755-62.
32. Burdick KE, Funke B, Goldberg JF, et al. COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord 2007;9:370-6. (Pubitemid 46865369)
33. Funke B, Malhotra AK, Finn CT, et al. COMT genetic variation confers risk for psychotic and affective disorders: A case control study. Behav Brain Funct 2005;1:19.
34. Shifman S, Bronstein M, Sternfeld M, et al. COMT: A common susceptibility gene in bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004;128B: 61-4. (Pubitemid 38849920)
35. Lachman H, Papolos D, Satio T, Yu YM, Szumlanski C, Weinshilboum R. Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243-50. (Pubitemid 26226317)
36. Lotta T, Vidgren J, Tilgmann C, et al. Kinetics of a soluble and membrane-bound catechol-O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995;34:4204-10.
37. Massat I, Souery D, Del-Favero J, et al. Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. Mol Psychiatry 2005; 10:598-605. (Pubitemid 40897044)
38. Drury SD, Theall KP, Smyke AT, et al. Modification of depression by COMT val158 met polymorphism in children exposed to early severe psychosocial deprivation. Child Abuse Negl 2010;34:387-95.
39. Marshall PJ, Fox NA; BEIP Core Group. A comparison of the electroencephalogram between institutionalized and community children in Romania. J Cogn Neurosci 2004;16:1327-38. (Pubitemid 39410966)
40. Barry RJ, Clarke AR, Johnstone SJ. A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clin Neurophysiol 2003;114:171-83. (Pubitemid 36136088)
41. Matsuura M, Okubo Y, Toru M, et al. A cross-national EEG study of children with emotional and behavioural problems: A WHO collaborative study in the western Pacific Region. Biol Psychiatry 1993;34:52-8.
42. Kinsbourne M. Minimal brain dysfunction as a neurodevelopmental lag. Ann N Y Acad Sci 1973;205:268-73.
43. Marshall PJ, Bar-Haim Y, Fox NA. Development of the EEG from 5 months to 4 years of age. Clin Neurophysiol 2002;113:1199-208. (Pubitemid 34874510)
44. Shaw P, Eckstrand K, Sharp W, et al. Attention-deficit/ hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A 2007;104:19649-54.
45. McLaughlin KA, Fox NA, Zeanah CH, Sheridan MA, Marshall P, Nelson CA. Delayed maturation in brain electrical activity partially explains the association between early environmental deprivation and symptoms of attention-deficit/hyperactivity disorder. Biol Psychiatry 2010;68:329-36.