Gram negative bacteria are associated with the early stages of necrotizing enterocolitis

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Carlisle, Erica M ^a   Poroyko, Valeriy ^a   Caplan, Michael S ^b   Alverdy, John A ^a   Liu, Donald ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; RNA 16S; TOLL LIKE RECEPTOR 4; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPHYXIA; CITROBACTER; COLON FLORA; CONTROLLED STUDY; ENTEROCOCCUS; FIRMICUTES; GRAM NEGATIVE BACTERIUM; HYPOTHERMIA; INTESTINE FLORA; KLEBSIELLA; MOUSE; NECROTIZING ENTEROCOLITIS; NONHUMAN; PATHOGENESIS; PRINCIPAL COMPONENT ANALYSIS; PROTEOBACTERIA; PSEUDOMONAS AERUGINOSA; PYROSEQUENCING; SERRATIA MARCESCENS; STREPTOCOCCUS; STREPTOCOCCUS THORALTENSIS; ANIMAL; C3H MOUSE; MICROBIOLOGY; NEWBORN; NUCLEOTIDE SEQUENCE; PATHOGENICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; BACTERIA (MICROORGANISMS); CITROBACTER; ENTEROCOCCUS; FIRMICUTES; KLEBSIELLA; MUS; NEGIBACTERIA; PROTEOBACTERIA; PSEUDOMONAS AERUGINOSA; SERRATIA MARCESCENS; STREPTOCOCCUS; STREPTOCOCCUS THORALTENSIS; TATUMELLA;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; DNA PRIMERS; ENTEROCOLITIS, NECROTIZING; GRAM-NEGATIVE BACTERIA; MICE; MICE, INBRED C3H; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79952926446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018084     Document Type: Article

References (30)

1. Kliegman RM, (1990) Models of the pathogenesis of necrotizing enterocolitis. J Pediatr 117: S2-5.
2. Anand RJ, Leaphart CL, Mollen KP, Hackam DJ, (2007) The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis. Shock 27: 124-133.
3. Jilling T, Simon D, Lu J, Meng FJ, Li D, et al. (2006) The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol 177: 3273-3282.
4. Tudehope DI, (2005) The epidemiology and pathogenesis of neonatal necrotizing enterocolitis. J Paediatr Child Health 41: 167-168.
5. Lee JS, Polin RA, (2003) Treatment and prevention of necrotizing enterocolitis. Semin Neonatol 8: 449-459.
6. Sodhi C, Richardson W, Gribar S, Hackam DJ, (2008) The development of animal models for the study of necrotizing enterocolitis. Dis Model Mech 1: 94-98.
7. Barlow B, Santulli TV, (1975) Importance of multiple episodes of hypoxia or cold stress on the development of enterocolitis in an animal model. Surgery 77: 687-690.
8. Caplan MS, Hedlund E, Adler L, Hsueh W, (1994) Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis. Pediatr Pathol 14: 1017-1028.
9. Nadler EP, Dickinson E, Knisely A, Zhang XR, Boyle P, et al. (2000) Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis. J Surg Res 92: 71-77.
10. Morowitz MJ, Poroyko V, Caplan M, Alverdy J, Liu DC, (2010) Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis. Pediatrics 125: 777-785.
11. Carrasco R, Pera M, May FE, Westley BR, Martinez A, et al. (2004) Trefoil factor family peptide 3 prevents the development and promotes healing of ischemia-reperfusion injury in weanling rats. J Pediatr Surg 39: 1693-1700.
12. Ceylan H, Yuncu M, Gurel A, Armutcu F, Gergerlioglu HS, et al. (2005) Effects of whole-body hypoxic preconditioning on hypoxia/reoxygenation-induced intestinal injury in newborn rats. Eur J Pediatr Surg 15: 325-332.
13. Cintra AE, Martins JL, Patricio FR, Higa EM, Montero EF, (2008) Nitric oxide levels in the intestines of mice submitted to ischemia and reperfusion: L-arginine effects. Transplant Proc 40: 830-835.
14. Caplan MS, Simon D, Jilling T, (2005) The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. Semin Pediatr Surg 14: 145-151.
15. Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, et al. (2007) A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol 179: 4808-4820.
16. Tian R, Liu SX, Williams C, Soltau TD, Dimmitt R, et al. (2010) Characterization of a necrotizing enterocolitis model in newborn mice. Int J Clin Exp Med 3: 293-302.
17. Jilling T, Lu J, Jackson M, Caplan MS, (2004) Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis. Pediatr Res 55: 622-629.
18. Magne F, Abely M, Boyer F, Morville P, Pochart P, et al. (2006) Low species diversity and high interindividual variability in faeces of preterm infants as revealed by sequences of 16S rRNA genes and PCR-temporal temperature gradient gel electrophoresis profiles. FEMS Microbiol Ecol 57: 128-138.
19. Poroyko V, White JR, Wang M, Donovan S, Alverdy J, et al. (2010) Gut microbial gene expression in mother-fed and formula-fed piglets. PLoS One 5: e12459.
20. Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, et al. (2009) Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 75: 7537-7541.
21. White JR, Nagarajan N, Pop M, (2009) Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput Biol 5: e1000352.
22. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, et al. (2005) Diversity of the human intestinal microbial flora. Science 308: 1635-1638.
23. Bell MJ, Feigin RD, Ternberg JL, (1979) Changes in the incidence of necrotizing enterocolitis associated with variation of the gastrointestinal microflora in neonates. Am J Surg 138: 629-631.
24. Cordero L, Rau R, Taylor D, Ayers LW, (2004) Enteric gram-negative bacilli bloodstream infections: 17 years' experience in a neonatal intensive care unit. Am J Infect Control 32: 189-195.
25. Mshvildadze M, Neu J, Shuster J, Theriaque D, Li N, et al. (2010) Intestinal microbial ecology in premature infants assessed with non-culture-based techniques. J Pediatr 156: 20-25.
26. de la Cochetiere MF, Piloquet H, des Robert C, Darmaun D, Galmiche JP, et al. (2004) Early intestinal bacterial colonization and necrotizing enterocolitis in premature infants: the putative role of Clostridium. Pediatr Res 56: 366-370.
27. Millar MR, Linton CJ, Cade A, Glancy D, Hall M, et al. (1996) Application of 16S rRNA gene PCR to study bowel flora of preterm infants with and without necrotizing enterocolitis. J Clin Microbiol 34: 2506-2510.
28. Young C, Sharma R, Handfield M, Mai V, Neu J, (2009) Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention? Pediatr Res 65: 91R-97R.
29. Halpern MD, Khailova L, Molla-Hosseini D, Arganbright K, Reynolds C, et al. (2008) Decreased development of necrotizing enterocolitis in IL-18-deficient mice. Am J Physiol Gastrointest Liver Physiol 294: G20-26.
30. Radulescu A, Zhang HY, Yu X, Olson JK, Darbyshire AK, et al. Heparin-binding epidermal growth factor-like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis. J Pediatr Surg 45: 1933-1939.